Exploring the Landscape of Adult Acute Poisoning in Saudi Arabia: A Comprehensive Narrative Review.

This narrative review meticulously examines the intricate landscape of poisoning incidents within Saudi Arabia, delineating the prevalence and characteristics across three main categories: pharmaceutical, illicit, and chemical substances. Pharmaceutical agents, particularly analgesics and antipsychotics, are identified as leading causes of acute adult poisoning, highlighting the paramount role of their widespread accessibility and the potential risks associated with over-the-counter availability. The review underscores the alarming prevalence of over-the-counter analgesics, such as paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs), as the most frequent culprits in poisoning cases, with a significant correlation observed between analgesic poisoning and gender, notably affecting the female population. Additionally, the study delves into the burgeoning issue of illicit drug use, with opioids and amphetamines emerging as substantial contributors to the poisoning landscape, reflecting a broader global trend of increasing substance misuse and its associated health risks. Chemical poisoning, encompassing a range of substances from household cleaners to industrial chemicals, presents another critical area of concern, with specific emphasis on the dangers posed by antiseptics, detergents, and organophosphates. The review identifies a pressing need for targeted public health interventions and policy reforms aimed at mitigating the risks associated with these diverse types of poisoning. By offering a comprehensive overview of the poisoning epidemiology in Saudi Arabia, the study contributes valuable insights into the multifaceted nature of this public health challenge, advocating for enhanced regulatory measures, public awareness campaigns, and improved access to mental health services to address the underlying factors contributing to poisoning incidents.

Investigating the Interrelationships Between Obesity, Academic Achievement, Physical Activity, and Social Support Among Jazan University Students.

Background: In developing and developed countries, the prevalence of overweight and obesity has grown. The college phase is a critical period during which healthy behaviors are learned through lifestyle and social environment. College students are prone to increased stress, negatively affecting their daily activities and academic performance. Objective: The general study objective was to investigate the prevalence of obesity among Jazan University students. Methods: This observational cross-sectional study used a pre-tested self-administered anonymous electronic questionnaire to evaluate the prevalence of obesity among 474 Jazan University students and its association with academic performance, physical activity, and social support. Data were analyzed using the Statistical Package for the Social Sciences, and associations between variables were assessed using the chi-square test. Results: Approximately 21% and 9.2% of the male and female students were obese, respectively, and the prevalence of obesity significantly differed between them. The use of one or more tobacco products was significantly associated with the prevalence of obesity (P < 0.001); the prevalence of obesity was substantially higher among the tobacco product users than among the non-users (35.3% vs. 14.4%). The presence of a morbidity was also significantly associated with the prevalence of obesity (P = 0.007); the prevalence of obesity was significantly higher among the students with at least one comorbidity than among the medically free students (28.8% vs. 14.9%). Conversely, obesity was not associated with academic performance and depression. Specifically, the grade point average was not affected across the academic years (P = 0.085 and P = 0.308, respectively). Conclusion: Obesity is significantly associated with male sex and the use of one or more tobacco products. This finding warrants the need for strategic and multidisciplinary plans at all levels to encourage healthy behaviors among college students, including an active, healthy lifestyle.

Efficacy of Low-Dose Isotretinoin in the Treatment of Rosacea: A Systematic Review and Meta-Analysis.

Rosacea is a common cutaneous condition caused by persistent, recurring lesions in facial skin vessels. It is a chronic skin condition with a variety of clinical symptoms and an unknown cause. Rosacea begins with the widening of capillaries and a flushed appearance. Following that, telangiectasia appears, and reddened patches persist, particularly on the cheeks and nose. Erythema persists due to repeated vasodilation and telangiectasia. In addition, skin inflammation manifests as papules, pustules, lymphedema, and fibrosis. Despite recent advances in treatment, rosacea, a chronic inflammatory relapsing central facial dermatosis, can be extremely difficult to manage.  The purpose of this meta-analysis and systematic review was to evaluate the effectiveness of low-dose isotretinoin in the treatment of rosacea. Following the guidelines set forth by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA), the researcher employed the following search terms in the EMBASE, Web of Science, PubMed, Cochrane Library, and Google Scholar databases to provide a therapeutic update relevant to clinical practice: "low dose isotretinoin," "isotretinoin and rosacea," "isotretinoin treatment of rosacea," and "effectiveness of isotretinoin in treating rosacea". The search was carried out by the researcher for articles published from February 2019 to February 2024. The articles included were all published in the English language. The overall frequency of patients with adverse events differed significantly between the groups treated with low-dose isotretinoin and the comparators (minocycline, pulsed dye laser, evening primrose oil, Lactobacillus plantarum, doxycycline, combined dose or placebo) (0.80, 95% CI 0.73 to 0.88, p = 0.0001). Sub-group analysis indicated that there was a difference between the interventions used in the treatments all in favor of low-dose isotretinoin treatment. The results showed that the moderate group had RR: 0.76, 95% CI: 0.44-1.30, I2 = 0%; the mild group had RR: 0.94, 95% CI: 0.56-1.57, I2 = 0%; and the group with severe rosacea had RR: 0.73, 95% CI: 0.47-1.13, I2 = 0%. According to this study, rosacea can be treated effectively with low-dose isotretinoin even in patients at severe stages of the disease by using the recommended dose once a week. Further, the intervention has also been shown to have fewer side effects on the patients. Therefore, this study recommends randomized controlled trials to be done to fully investigate the best combination options for isotretinoin on mild to severe rosacea based on the fact that some of the treatments combined have shown to be effective on treatment.

The Impact of Artificial Intelligence on the Preference of Radiology as a Future Specialty Among Medical Students at Jazan University, Saudi Arabia: A Cross-Sectional Study.

Background The use of artificial intelligence (AI) in healthcare continues to spark interest and has been the subject of extensive discussion in recent years as well as its potential effects on future medical specialties, including radiology. In this study, we aimed to study the impact of AI on the preference of medical students at Jazan University in choosing radiology as a future specialty. Methodology An observational cross-sectional study was conducted using a pre-tested self-administered online questionnaire among medical students at Jazan University. Data were cleaned, coded, entered, and analyzed using SPSS (SPSS Inc., USA) version 25. Statistical significance was defined as a P-value of less than 0.05. We examined the respondents' preference for radiology rankings with the presence and absence of AI. Radiology's ranking as a preferred specialty with or without AI integration was statistically analyzed for associations with baseline characteristics, personal opinions, and previous exposures among those who had radiology as one of their top three options. Results Approximately 27.4% of males and 28.3% of females ranked radiology among their top three preferred choices. Almost 65.2% were exposed to radiology topics through pre-clinical lectures. The main sources of information about AI for the studied group were medical students (41%) and the Internet (27.5%). The preference of students for radiology was significantly affected when it is assessed by AI (P < 0.05). Around (16.1%) of those who chose radiology as one of their top three choices strongly agree that AI will decrease the job opportunities for radiologists. Logistic regression analysis showed that being a female is significantly associated with an increased chance to replace radiology with other specialty when it is integrated with AI (Crude odds ratio (COR) = 1.91). Conclusion Our results demonstrated that the students' choices were significantly affected by the presence of AI. Thereover, to raise medical students' knowledge and awareness of the potential positive effects of AI, it is necessary to organize an educational campaign, webinars, and conferences.

Clinimetric properties of a smartphone application to measure the craniovertebral angle in different age groups and positions.

Background: Craniovertebral angle (CVA) alteration is a causative factor for the neck, shoulder, and temporomandibular joints disorders. Therefore, as an outcome measure for therapeutic intervention, measuring the craniovertebral angle with the Surgimap smartphone app is a cost-effective, easily accessible, and reliable tool. This study's objective was to assess the clinimetric properties of the Surgimap smartphone application with Surgimap system software to measure the Craniovertebral Angle in different age groups and positions. Method: Ninety subjects with neck pain were randomly allocated to aged between 18 and 30 years (Group A; n = 45) and 45-60 years (Group B; n = 45). Using the Surgimap smartphone application and Surgimap system software, the craniovertebral angle was measured objectively in the sagittal plane. Intraclass correlation coefficients were used to determine validity and reliability. Receiver operating characteristic (ROC) curves and the area under the curves (AUC) were determined to distinguish participants with and without forward head posture. Result: The result of this study shows that Smartphone Surgimap Application and Surgimap System Software correlate 0.95 and have p-values of 0.01 for diverse positions and ages. CVA measurement in the sitting position was significantly lower than in the standing position, regardless of methodology or age. Both positions demonstrated high intra-rater reliability, as evidenced by Intraclass Correlation Coefficients (ICC) between 0.972 and 0.991. The minimum detectable change (MDC) values ranged from 1.3 to 1.733, indicating high measurement accuracy. The smartphone application demonstrated outstanding diagnostic sensitivity (100.00% for Group A standing) and specificity (93.55% for Group B standing). Conclusion: The Surgimap smartphone application is a reliable and accurate method for craniovertebral angle measurement and is useful for measuring outcomes. Also standing posture was found to be better than sitting posture while measuring the CVA.

Perception and Assessment of Psoriasis Among the General Population in the Jazan Region, Saudi Arabia.

BACKGROUND: Psoriasis is a worldwide disease. It is a chronic immune-mediated inflammatory disease with cutaneous and systemic symptoms that is characterized by erythematous squamous plaques. OBJECTIVES: To study the perception and assessment of psoriasis among the general population of Jazan, Saudi Arabia. MATERIALS AND METHODS: This was a cross-sectional study that used a self-administrated electronically distributed questionnaire that enrolled 410 people. RESULTS: Most participants (79%) were familiar with the term "psoriasis," with family, friends, or acquaintances being the primary source of knowledge. Personal experience with psoriasis was reported by 28.3% of participants, with women being more likely to know someone with the condition. If affected by psoriasis, the majority of respondents would consult a dermatologist (89.3%). Although 48% of participants considered psoriasis to be a significant burden for affected individuals, negative attitudes and discrimination towards those with the condition were prevalent, with a significant proportion stating that they would not want to eat at the same table, shake hands, or be in a personal relationship with someone with psoriasis. Additionally, most participants reported feeling sorry for psoriasis patients but also expressed disgust towards them. Awareness of public actions related to psoriasis was generally low, with only a small percentage of participants familiar with the WHO resolution on psoriasis or World Psoriasis Day. CONCLUSION: This study highlights the need for increased education and awareness about psoriasis to address misunderstandings and reduce the burden of the condition on patients. Additionally, efforts are needed to reduce stigma and discrimination towards those with psoriasis, which can significantly impact their quality of life.

The Association between SARS-CoV-2 Infection and Diabetic Ketoacidosis in Patients with New-Onset Diabetes: A Retrospective Study from a Diabetic Center in Saudi Arabia.

BACKGROUND: Various reports described new-onset diabetes during or after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with no previous history of diabetes or glucocorticoid use. Further, SARS-CoV-2 could increase the risk of diabetes, including diabetic ketoacidosis (DKA). However, data on the relationship between new-onset diabetes and COVID-19 are still limited in our region. Thus, we aimed in this study to evaluate the association between new-onset diabetes and DKA in patients with COVID-19. METHODS: A retrospective, cross-sectional study was conducted at a diabetic center in Jazan province, Saudi Arabia, between 2020 and 2021. Demographic data, COVID-19 status, and DKA incidence were collected and verified manually from diabetic patients' medical records. Data were analyzed using a t-test and chi-square test. RESULTS: We included 54 diabetic patients diagnosed during the COVID-19 pandemic, with a median age of 17 years. The majority of patients were females (57.4%). About 38.8% were diagnosed with COVID-19, and 16.6% reported having DKA. About 33.3% of the patients who experienced DKA reported being COVID-19-positive. However, only 6% of patients who denied contracting SARS-CoV-2 developed DKA (p-value = 0.020). CONCLUSIONS: Patients with newly diagnosed diabetes due to COVID-19 seem at a higher risk of developing DKA. Further epidemiological and molecular studies are required for a better understanding of the correlation between DKA in patients with diabetes and COVID-19.

Knowledge, Attitude and Practices regarding Contraceptive Pill and Its Side Effects among Women in Jazan Region, Saudi Arabia.

Contraception is one of the common methods of family planning. The oral contraceptive pill (OCP) is among the most effective methods of contraception. This study aimed to assess the knowledge, attitude, and practice of oral contraception use and its side effects among women in the Jazan region, Saudi Arabia. A cross-sectional study was carried out among adult women 18 years and older in the Jazan region. A pre-tested questionnaire was used to assess their demographic characteristics, knowledge, attitudes, previous experience, and pattern of OCP usage. Descriptive analysis and a logistic regression model were used to analyse data. About 570 questionnaires were distributed and achieved a 98.3% response rate. The majority of women participants were between 18 and 25 years old, and 51.4% of the respondents reported that they had previously used or were using OCP. We found that women had good knowledge and a positive attitude towards OCP, with more than half of the users preferring them over other contraceptive methods. This study indicates that attitude, knowledge, and prior experience of OCP have no significant effect on the usage pattern of OCP among women with relatively high socioeconomic status in the Jazan region, Saudi Arabia.

Mental Stigma Among Al-Ahsa Population in Saudi Arabia.

Introduction Mental stigma is when patients of mental illness are labeled by their disorders, viewed negatively, and discriminated against due to their illness. This has a big impact on people's attitudes and behaviors toward the mentally ill. Moreover, mental stigma leads people to avoid patients with mental health issues, blame them for their conditions, and associate them with negative features like being dangerous, unpredictable, and hard to communicate with. The primary objective of this study is to assess the mental stigma among the population of the Al-Ahsa region in Saudi Arabia. Methods This is a cross-sectional study conducted in Al-Ahsa, Saudi Arabia, between June and August 2021. The target population of the study was people aged 18-65 years old whose place of residency during the time of the study was Al-Ahsa. The questionnaire used in this study contained a mental stigma scale called community attitudes toward mental illness (CAMI). Results A total of 758 participants were enrolled in the study. The mean of the stigma score was 99.24 ± 15.622, with a minimum of 53 and a maximum of 176. The means of the subscales were as follows: authoritarianism (26.18 ± 4.420), benevolence (23.26 ± 4.762), community mental health ideology (24.66 ± 5.896), and social restrictiveness (25.13 ± 4.6). There was a positive relationship between age and stigma score. Healthcare workers were found to have a lower level of stigma, as were those who spoke more languages. Also, being diagnosed with a mental illness and knowing someone who is diagnosed with a mental illness were associated with a lower level of stigma. Conclusion Most of the population (91.96%) had a low to medium-low level of stigma. The variables found to affect the level of stigma were age, career, number of spoken languages, being diagnosed with a mental illness, and knowing someone who is diagnosed with a mental illness. Mental stigma has a great impact on the person, as it can prevent the patient from seeking help, lead to isolation, and suicidal ideation. Future stigma-targeted campaigns are recommended.

The endonasal endoscopic management of pediatric lateral frontal mucocele.

OBJECTIVES: The aim of this report is to show the usefulness of endoscopic sinus surgery in management of lateral frontal mucocele in pediatric patient. CASE PRESENTATION: A 14 years old girl presented with right frontal bone depression and headache. CT and MRI showed lateral mucocele occupying the right frontal sinus. The patient was managed successfully by image-guided endoscopic sinus surgery and she was well after two years follow up. DISCUSSION & CONCLUSION: Frontal mucoceles in children are rare. We report a rare case of a child with lateral frontal mucocele with no known etiology, treated successfully by image-guided endoscopic sinus surgery with no recurrence after two years follow-up. This case shows the usefulness of image-guided endoscopic sinus surgery in treatment of lateral frontal mucocele in children.

Clinical, Biochemical, and Molecular Characterization of Neonatal-Onset Dubin-Johnson Syndrome in a Large Case Series From the Arabs.

Background: There are only a few case reports and small case series on neonatal-onset Dubin-Johnson syndrome (DJS), particularly from Far-East Asia, Iranian and Moroccan Jews, and Europe. Objectives: In this first study from the Arabs and the largest series reported to date, we characterized the clinical, laboratory, and molecular features and outcome of gene-confirmed neonatal-onset DJS. Methods: We reviewed our database of 533 cases of neonatal cholestasis that presented to our center during the period from 2008 to 2019. We identified neonates with a disease-causing mutation in ABCC2 gene. Results: Twenty-eight neonates with DJS were diagnosed (5.3%). All of the 28 were full-term, well looking neonates without hepatosplenomegaly, with cholestasis, and normal liver synthetic function since the 1 week of life that resolved within 3-6 months of age, followed by a benign course punctuated by recurrent episodes of jaundice in 43% during a median follow up period of 9.25 (range 2.5-14 years). Alanine aminotransferase levels were within normal range in 26 patients (92%) and mildly elevated in two patients. ALT levels were significantly lower in neonates with DJS than in other cases with neonatal cholestasis from other causes (p < 0.001). The median urinary coproporphyrin I% was 88% (IQ1-IQ3 = 84.2-92.7%). We identified four homozygous variants in the ABCC2 gene (from 22 unrelated families), one splicing variant (c.3258+1G>A; p.?), and three were missense variants; two of which were novel missense variants [c.1594G>A (p.Glu532Lys) and c.2439G>C (p.Lys813Asn)]. The p.Gly758Val mutation has occurred in 23 patients (from 19 unrelated families). Conclusions: Our study suggests that normal ALT-cholestasis in a well-looking neonate should trigger evaluation for DJS. The p.Gly758Val variant in ABCC2 is the most predominant mutation among Arabs with "founder effects." Identification of the predominant ABCC2 variant in any population is likely to facilitate rapid molecular analysis by future targeting of that specific mutation.

Hypoglycemic and Hypolipidemic Properties of Ethanolic Extract of Brassica oleracea in Streptozotocin-Induced Diabetic Rats

Diabetes mellitus has become the most prevalent metabolic disease worldwide. The edible leaves of Red cabbage(Brassica oleracea L.) is one of the most regularly consumed vegetables in Arabic countries. Thus, it was ofinterest to assess the hypoglycemic and hypolipidemic impacts of ethanolic (50 %) extract of the leaves of redcabbage on blood glucose, glycated hemoglobin (HbA1c) and lipid profile in streptozotocin (STZ)-induceddiabetic rats. Diabetes was induced in male Wistar rats by injecting rats with 60 mg/Kg bodyweight ofstreptozotocin. Diabetic rats demonstrated a significant increase in serum glucose, glycated hemoglobin (HbA1c)total cholesterol (TC), and triacylglycerol (TG). Daily oral supplementation (250 mg/Kg body weight) of extractof red cabbage leaves for 40 days to STZ-induced diabetic rats significantly ameliorated HbA1c (p < 0.01), TG(p < 0.01), serum glucose (p < 0.01), and TC (p < 0.01). By comparison, a standard anti-hyperglycemic drug,Glibenclamide, when administered at a dose of 10 mg/kg body weight, decreased TC, blood glucose, HbA1c, andTGs levels. It is concluded that the ethanolic extract of red cabbage decreased the blood levels of HbA1c, glucose,and lipids and it was more efficient than Glibenclamide in reducing blood glucose.