Detalhe da pesquisa
1.
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Drug Metab Dispos
; 41(4): 714-26, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23305709
2.
Physiologically-Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid-to-Lactone Conversion.
CPT Pharmacometrics Syst Pharmacol
; 8(9): 664-675, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31250974
3.
Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.
J Med Chem
; 61(5): 2041-2051, 2018 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425457