Pesquisa | Biblioteca Virtual em Saúde

1.

Probing the Cytotoxic Signaling Induced by Eupenifeldin in Ovarian Cancer Models.

Maldonado, Amanda C; Haughan, Monica A; Khin, Manead; Ekiert, Julia; Zhang, Ziwei; Lantvit, Daniel; Al Subeh, Zeinab Y; Pierre, Herma C; Salkovski, Maryna; Hirschhorn, Tal; Gao, Yu; Pearce, Cedric J; Stockwell, Brent R; Aldrich, Leslie N; Oberlies, Nicholas H; Burdette, Joanna E.

J Nat Prod ; 86(9): 2102-2110, 2023 09 22.

Artigo em Inglês | MEDLINE | ID: mdl-37643353

2.

Discovery of Anticancer Agents of Diverse Natural Origin.

Aldrich, Leslie N; Burdette, Joanna E; Carcache de Blanco, Esperanza; Coss, Christopher C; Eustaquio, Alessandra S; Fuchs, James R; Kinghorn, A Douglas; MacFarlane, Amanda; Mize, Brittney K; Oberlies, Nicholas H; Orjala, Jimmy; Pearce, Cedric J; Phelps, Mitch A; Rakotondraibe, Liva Harinantenaina; Ren, Yulin; Soejarto, Djaja Doel; Stockwell, Brent R; Yalowich, Jack C; Zhang, Xiaoli.

J Nat Prod ; 85(3): 702-719, 2022 03 25.

Artigo em Inglês | MEDLINE | ID: mdl-35213158

3.

Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I.

Pavlinov, Ivan; Salkovski, Maryna; Aldrich, Leslie N.

J Am Chem Soc ; 142(18): 8174-8182, 2020 05 06.

Artigo em Inglês | MEDLINE | ID: mdl-32320221

4.

Multiple Chemical Features Impact Biological Performance Diversity of a Highly Active Natural Product-Inspired Library.

Hippman, Ryan S; Pavlinov, Ivan; Gao, Qiwen; Mavlyanova, Michelle K; Gerlach, Erica M; Aldrich, Leslie N.

Chembiochem ; 21(21): 3137-3145, 2020 11 02.

Artigo em Inglês | MEDLINE | ID: mdl-32558167

5.

Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity.

Pavlinov, Ivan; Gerlach, Erica M; Aldrich, Leslie N.

Org Biomol Chem ; 17(7): 1608-1623, 2019 02 13.

Artigo em Inglês | MEDLINE | ID: mdl-30328455

6.

Microwave-Assisted, Asymmetric Synthesis of 3-Amino-2,3-Dihydrobenzofuran Flavonoid Derivatives from Chalcones.

Helgren, Travis R; Xu, Lianyan L; Sotelo, Daniel; Mehta, Yash R; Korkmaz, Melissa A; Pavlinov, Ivan; Aldrich, Leslie N.

Chemistry ; 24(18): 4509-4514, 2018 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-29446184

7.

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Kuo, Szu-Yu; Castoreno, Adam B; Aldrich, Leslie N; Lassen, Kara G; Goel, Gautam; Dancík, Vlado; Kuballa, Petric; Latorre, Isabel; Conway, Kara L; Sarkar, Sovan; Maetzel, Dorothea; Jaenisch, Rudolf; Clemons, Paul A; Schreiber, Stuart L; Shamji, Alykhan F; Xavier, Ramnik J.

Proc Natl Acad Sci U S A ; 112(31): E4281-7, 2015 Aug 04.

Artigo em Inglês | MEDLINE | ID: mdl-26195741

8.

Lipids lead the way.

Aldrich, Leslie N.

Nat Chem Biol ; 15(7): 653-654, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31222191

9.

Preface.

Aldrich, Leslie N.

Bioorg Med Chem ; 33: 116027, 2021 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-33486161

10.

Discovery of a Small-Molecule Probe for V-ATPase Function.

Aldrich, Leslie N; Kuo, Szu-Yu; Castoreno, Adam B; Goel, Gautam; Kuballa, Petric; Rees, Matthew G; Seashore-Ludlow, Brinton A; Cheah, Jaime H; Latorre, Isabel J; Schreiber, Stuart L; Shamji, Alykhan F; Xavier, Ramnik J.

J Am Chem Soc ; 137(16): 5563-8, 2015 Apr 29.

Artigo em Inglês | MEDLINE | ID: mdl-25860544

11.

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Conway, Kara L; Kuballa, Petric; Song, Joo-Hye; Patel, Khushbu K; Castoreno, Adam B; Yilmaz, Omer H; Jijon, Humberto B; Zhang, Mei; Aldrich, Leslie N; Villablanca, Eduardo J; Peloquin, Joanna M; Goel, Gautam; Lee, In-Ah; Mizoguchi, Emiko; Shi, Hai Ning; Bhan, Atul K; Shaw, Stanley Y; Schreiber, Stuart L; Virgin, Herbert W; Shamji, Alykhan F; Stappenbeck, Thaddeus S; Reinecker, Hans-Christian; Xavier, Ramnik J.

Gastroenterology ; 145(6): 1347-57, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23973919

12.

Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation.

Panarese, Joseph D; Konkol, Leah C; Berry, Cynthia B; Bates, Brittney S; Aldrich, Leslie N; Lindsley, Craig W.

Tetrahedron Lett ; 54(18): 2231-2234, 2013 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-23606772

13.

Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model.

Aldrich, Leslie N; Berry, Cynthia B; Bates, Brittney S; Konkol, Leah C; So, Miranda; Lindsley, Craig W.

European J Org Chem ; 2013(20)2013 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-24415906

14.

Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons.

Hippman, Ryan S; Snead, Amanda M; Petros, Zoe A; Korkmaz-Vaisys, Melissa A; Patel, Sruchi; Sotelo, Daniel; Dobria, Andrew; Salkovski, Maryna; Nguyen, Thu T A; Linares, Ricardo; Cologna, Stephanie M; Gowrishankar, Swetha; Aldrich, Leslie N.

ACS Chem Neurosci ; 14(24): 4363-4382, 2023 Dec 20.

Artigo em Inglês | MEDLINE | ID: mdl-38069806

15.

PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.

Salvi, Amrita; Young, Alexandria N; Huntsman, Andrew C; Pergande, Melissa R; Korkmaz, Melissa A; Rathnayake, Rathnayake A; Mize, Brittney K; Kinghorn, A Douglas; Zhang, Xiaoli; Ratia, Kiira; Schirle, Markus; Thomas, Jason R; Brittain, Scott M; Shelton, Claude; Aldrich, Leslie N; Cologna, Stephanie M; Fuchs, James R; Burdette, Joanna E.

Cell Death Dis ; 13(1): 45, 2022 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-35013112

16.

Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5-ATG16L1 Protein-Protein Interaction Inhibitors.

Salkovski, Maryna; Pavlinov, Ivan; Gao, Qiwen; Aldrich, Leslie N.

SLAS Discov ; 26(7): 933-943, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-33783243

17.

Autophagy and post-ischemic conditioning in retinal ischemia.

Mathew, Biji; Chennakesavalu, Mohansrinivas; Sharma, Monica; Torres, Leianne A; Stelman, Clara R; Tran, Sophie; Patel, Raj; Burg, Nathan; Salkovski, Maryna; Kadzielawa, Konrad; Seiler, Figen; Aldrich, Leslie N; Roth, Steven.

Autophagy ; 17(6): 1479-1499, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-32452260

18.

Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs.

Aldrich, Leslie N; Stoops, Sydney L; Crews, Brenda C; Marnett, Lawrence J; Lindsley, Craig W.

Bioorg Med Chem Lett ; 20(17): 5207-11, 2010 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-20655217

19.

MAOS ls for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines.

Aldrich, Leslie N; Lebois, Evan P; Lewis, L Michelle; Nalywajko, Natalia T; Niswender, Colleen M; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W.

Tetrahedron Lett ; 50(2): 212-215, 2009 Jan 14.

Artigo em Inglês | MEDLINE | ID: mdl-22090663

20.

Systematic Diversity-Oriented Synthesis of Reduced Flavones from Î³-Pyrones to Probe Biological Performance Diversity.

Gerlach, Erica M; Korkmaz, Melissa A; Pavlinov, Ivan; Gao, Qiwen; Aldrich, Leslie N.

ACS Chem Biol ; 14(7): 1536-1545, 2019 07 19.

Artigo em Inglês | MEDLINE | ID: mdl-31184855

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