Detalhe da pesquisa
1.
A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.
Nature
; 562(7727): 429-433, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297801
2.
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 54(2): 64-74, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38197324
3.
PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.
Proc Natl Acad Sci U S A
; 114(46): 12249-12254, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29087303
4.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Drug Metab Dispos
; 44(12): 1881-1889, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27638506
5.
Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging.
Drug Metab Dispos
; 42(7): 1110-6, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24754926
6.
Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.
Proc Natl Acad Sci U S A
; 108(23): 9589-94, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21597001
7.
Retrospective Assessment of Translational Pharmacokinetic-Pharmacodynamic Modeling Performance: A Case Study with Apitolisib, a Dual PI3K/mTOR Inhibitor.
Drugs R D
; 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38700808
8.
Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts.
Breast Cancer Res Treat
; 139(1): 61-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23605084
9.
Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist.
Drug Metab Dispos
; 41(12): 2104-13, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24041744
10.
Growth-rate model predicts in vivo tumor response from in vitro data.
CPT Pharmacometrics Syst Pharmacol
; 11(9): 1183-1193, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35731938
11.
Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process.
Xenobiotica
; 41(12): 1076-87, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21864203
12.
X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists.
J Biol Chem
; 284(50): 34553-60, 2009 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19854829
13.
Generalized Additive Mixed Modeling of Longitudinal Tumor Growth Reduces Bias and Improves Decision Making in Translational Oncology.
Cancer Res
; 80(22): 5089-5097, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32978171
14.
Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge.
J Immunother Cancer
; 8(2)2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32675310
15.
In vivo biodistribution, PET imaging, and tumor accumulation of 86Y- and 111In-antimindin/RG-1, engineered antibody fragments in LNCaP tumor-bearing nude mice.
J Nucl Med
; 50(3): 435-43, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19223400
16.
Targeting tomoregulin for radioimmunotherapy of prostate cancer.
Cancer Res
; 65(7): 2846-53, 2005 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15805286
17.
Identification of a novel prostate tumor target, mindin/RG-1, for antibody-based radiotherapy of prostate cancer.
Cancer Res
; 65(18): 8397-405, 2005 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16166318
18.
The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models.
Mol Cancer Ther
; 5(9): 2158-64, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16985048
19.
Stem cell plasticity enables hair regeneration following Lgr5+ cell loss.
Nat Cell Biol
; 19(6): 666-676, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28553937
20.
IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition.
Cell Death Dis
; 13(9): 831, 2022 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36171193