RESUMO
Recent studies have shown that psoriasis is associated with an increased prevalence of erectile dysfunction. To our knowledge, no comparative study has considered simultaneously the role of organic factors and psychological factors in this process. We performed a prospective case series study matched by age to explore the prevalence of erectile dysfunction in psoriasis patients compared to a healthy population and to investigate the role of anxiety, depression, and cardiovascular risk factors in the relationship between psoriasis and erectile dysfunction. The healthy group was matched by frequency to cases by age. Seventy-nine patients with moderate to severe psoriasis and 79 healthy controls participated in the study. Participants completed the Massachusetts General Hospital Sexual Functioning Questionnaire and the Hospital Anxiety and Depression Scale. Psoriasis patients had an increased prevalence of erectile dysfunction in comparison to controls, 34.2 vs. 17.7 % (p < .05). Multivariate analysis showed a significant association between erectile dysfunction and age, smoking and anxiety/depression, but not with psoriasis per se. In conclusion, the higher prevalence of smoking and anxiety/depression among patients with moderate to severe psoriasis probably explains the higher prevalence of erectile dysfunction in this population.
Assuntos
Disfunção Erétil/epidemiologia , Psoríase/complicações , Adulto , Ansiedade , Doenças Cardiovasculares/complicações , Depressão , Disfunção Erétil/complicações , Disfunção Erétil/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Prevalência , Estudos Prospectivos , Psoríase/psicologia , Fatores de Risco , Fumar/efeitos adversosRESUMO
Palmoplantar lichen planus is a localized and rare subtype of lichen planus (LP) often underdiagnosed. Several morphological types of palmoplantar lesions have been defined in LP. We present an unusual case of the palmoplantar kyperkeratotic variant of LP. Histopathology examination confirmed our diagnosis. We emphasize the importance of this rare entity in the differential diagnosis of palmoplantar dermatoses.
Assuntos
Dermatoses do Pé/diagnóstico , Dermatoses da Mão/diagnóstico , Ceratodermia Palmar e Plantar/diagnóstico , Líquen Plano/diagnóstico , Diagnóstico Diferencial , Dermatoses do Pé/etiologia , Dermatoses da Mão/etiologia , Humanos , Ceratodermia Palmar e Plantar/etiologia , Líquen Plano/complicações , Masculino , Pessoa de Meia-IdadeRESUMO
INTRODUCTION: Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relationship. However, beyond genital psoriasis, the importance of the distribution pattern of the disease has not been considered. AIM: To investigate the role of the distribution pattern of psoriasis in sexual dysfunction. METHODS: A prospective case series study was carried out on 133 patients with moderate to severe psoriasis. MAIN OUTCOME MEASURES: The participants completed the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, and the Self-Administered Psoriasis Area and Severity Index. RESULTS: Forty-four women (mean age 42.0 ± 14.1) and 79 men (mean age 47 ± 11.7) were included in the study. Psoriasis lesions on abdomen, genitals, lumbar region, and buttocks in women and chest, genitals, and buttocks in men were associated with an increase in sexual dysfunction. Multivariate logistic regression analysis showed that the involvement of these specific areas may be independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. CONCLUSIONS: This is the first study identifying body areas other than genitals as potentially related to sexual dysfunction in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when deciding on treatment for psoriasis patients.
Assuntos
Doenças dos Genitais Femininos/psicologia , Doenças dos Genitais Masculinos/psicologia , Psoríase/psicologia , Autoimagem , Índice de Gravidade de Doença , Disfunções Sexuais Psicogênicas/psicologia , Adulto , Idoso , Ansiedade/etiologia , Imagem Corporal , Depressão/etiologia , Feminino , Doenças dos Genitais Femininos/complicações , Doenças dos Genitais Masculinos/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Psoríase/complicações , Disfunções Sexuais Psicogênicas/etiologia , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: We present a case of eosinophilic pustular folliculitis, a rare dermatosis which is often associated with HIV infection or internal malignancies. CLINICAL PRESENTATION AND INTERVENTION: We report the case of a 66-year-old man with a medical history of hypertension. Histopathological examination showed a dense follicular inflammatory infiltrate with abundant eosinophils. The clinical response to indomethacin was excellent with no recurrence during the follow-up. CONCLUSION: The patient responded well to indomethacin treatment.
Assuntos
Eosinofilia/diagnóstico , Foliculite/diagnóstico , Dermatopatias Vesiculobolhosas/diagnóstico , Idoso , Anti-Inflamatórios não Esteroides/uso terapêutico , Eosinofilia/tratamento farmacológico , Eosinofilia/etiologia , Foliculite/tratamento farmacológico , Foliculite/etiologia , Humanos , Imunocompetência , Indometacina/uso terapêutico , Masculino , Dermatopatias Vesiculobolhosas/tratamento farmacológico , Dermatopatias Vesiculobolhosas/etiologiaAssuntos
Doenças do Pé/diagnóstico , Neurofibrossarcoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Biomarcadores Tumorais/análise , Diagnóstico Diferencial , Doenças do Pé/patologia , Doenças do Pé/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Neurofibrossarcoma/patologia , Pele/patologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with features of deep penetrating nevus.
Assuntos
Nevo Pigmentado/patologia , Neoplasias Cutâneas/patologia , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Melanoma/patologia , Nevo/patologiaRESUMO
BACKGROUND: Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relation. However, beyond genital psoriasis, the importance of the disease's distribution patterns has not been considered. OBJECTIVES: To research sexual function in psoriasis patients and investigate the roles of anxiety, depression and psoriasis' distribution patterns in sexual dysfunction. METHODS: A comparative study matched for sex and age was performed. Eighty patients with moderate to severe psoriasis and 80 healthy controls were included. The participants completed the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, and the Self-Administered Psoriasis Area and Severity Index. RESULTS: Psoriasis was associated with sexual dysfunction, odds ratio=5.5 (CI 95% 2.6-11.3; p<0.001). Certain distribution patterns of psoriasis, involving specific body regions, were associated with an increase in sexual dysfunction in the group presenting the disease, odds ratio 7.9 (CI 95% 2.3-33.4; p<0.001). Multivariate logistic regression analysis identified anxiety and depression, and the involvement of these specific areas, as possible independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. CONCLUSION: This study identifies body areas potentially related to sexual dysfunction, independently of anxiety and depression, in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when choosing the treatment for psoriasis patients.
Assuntos
Ansiedade/psicologia , Depressão/psicologia , Psoríase/psicologia , Disfunções Sexuais Psicogênicas/psicologia , Adulto , Imagem Corporal/psicologia , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Disfunções Sexuais Psicogênicas/etiologia , Estatísticas não Paramétricas , Inquéritos e Questionários , Escala de Ansiedade Frente a TesteRESUMO
Granular cell tumour is a rare tumour of neural origin usually located on the face and the neck. The biological behaviour is usually benign. However, certain clinical and histopathological features should alert physicians to a malignant behaviour. This case report describes the occurrence of a granular cell tumour in the inguinal area that resembled a malignant tumour. The histopathological study revealed typical features of granular cell tumour and an extension study confirmed the absence of metastasis. This case highlights the importance of considering this disorder in the differential diagnosis of ulcerated nodules and of managing atypical granular cell tumor appropriately.
Assuntos
Tumor de Células Granulares/patologia , Neoplasias Cutâneas/patologia , Feminino , Virilha , Humanos , Pessoa de Meia-Idade , Úlcera Cutânea/patologiaRESUMO
Abstract: Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with features of deep penetrating nevus.
Assuntos
Humanos , Feminino , Adulto , Neoplasias Cutâneas/patologia , Nevo Pigmentado/patologia , Diagnóstico Diferencial , Melanoma/patologia , Nevo/patologiaAssuntos
Antígeno Ki-1/imunologia , Linfoma Cutâneo de Células T/patologia , Pele/patologia , Biópsia por Agulha , Terapia Combinada , Seguimentos , Humanos , Imuno-Histoquímica , Extremidade Inferior , Linfoma Cutâneo de Células T/diagnóstico , Linfoma Cutâneo de Células T/terapia , Masculino , Metotrexato/administração & dosagem , Pessoa de Meia-Idade , Medição de Risco , Resultado do Tratamento , Terapia Ultravioleta/métodosAssuntos
Artrite Infecciosa/tratamento farmacológico , Hiperpigmentação/induzido quimicamente , Minociclina/efeitos adversos , Artrite Infecciosa/etiologia , Artrite Reumatoide/complicações , Denosumab/uso terapêutico , Quimioterapia Combinada , Feminino , Humanos , Falência Renal Crônica/complicações , Melanose/induzido quimicamente , Pessoa de Meia-Idade , Minociclina/uso terapêutico , Prednisona/uso terapêuticoRESUMO
Abstract BACKGROUND: Psoriasis may significantly impair sexual function. Depression and organic factors appear to play a key role in this relation. However, beyond genital psoriasis, the importance of the disease's distribution patterns has not been considered. OBJECTIVES: To research sexual function in psoriasis patients and investigate the roles of anxiety, depression and psoriasis' distribution patterns in sexual dysfunction. METHODS: A comparative study matched for sex and age was performed. Eighty patients with moderate to severe psoriasis and 80 healthy controls were included. The participants completed the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, and the Self-Administered Psoriasis Area and Severity Index. RESULTS: Psoriasis was associated with sexual dysfunction, odds ratio=5.5 (CI 95% 2.6-11.3; p<0.001). Certain distribution patterns of psoriasis, involving specific body regions, were associated with an increase in sexual dysfunction in the group presenting the disease, odds ratio 7.9 (CI 95% 2.3-33.4; p<0.001). Multivariate logistic regression analysis identified anxiety and depression, and the involvement of these specific areas, as possible independent risk factors for sexual dysfunction in patients with moderate to severe psoriasis. CONCLUSION: This study identifies body areas potentially related to sexual dysfunction, independently of anxiety and depression, in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when choosing the treatment for psoriasis patients. .
Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ansiedade/psicologia , Depressão/psicologia , Psoríase/psicologia , Disfunções Sexuais Psicogênicas/psicologia , Imagem Corporal/psicologia , Estudos de Casos e Controles , Índice de Gravidade de Doença , Estatísticas não Paramétricas , Inquéritos e Questionários , Disfunções Sexuais Psicogênicas/etiologia , Escala de Ansiedade Frente a TesteRESUMO
Granular cell tumour is a rare tumour of neural origin usually located on the face and the neck. The biological behaviour is usually benign. However, certain clinical and histopathological features should alert physicians to a malignant behaviour. This case report describes the occurrence of a granular cell tumour in the inguinal area that resembled a malignant tumour. The histopathological study revealed typical features of granular cell tumour and an extension study confirmed the absence of metastasis. This case highlights the importance of considering this disorder in the differential diagnosis of ulcerated nodules and of managing atypical granular cell tumor appropriately.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologia , Tumor de Células Granulares/patologia , Úlcera Cutânea/patologia , VirilhaRESUMO
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