Smartwatch reminders are as effective as verbal reminders in patients with Korsakoff's syndrome: three case studies.

Korsakoff's syndrome (KS) is a neurocognitive disorder caused by severe malnutrition. KS patients typically show severe impairments in prospective memory (PM), thus, have difficulties with remembering to perform delayed intentions. The current study investigated the possible benefits of a smartwatch aid for PM tasks in patients with KS and compared its efficacy with verbal in-person reminders. Three patients participated in the present study and were asked to complete everyday PM tasks. The results of each patient were analyzed as a single-case study. The results highlight the great potential of using smartwatches as external memory aids in KS patients in everyday life.

Redefining the pattern of age-prospective memory-paradox: new insights on age effects in lab-based, naturalistic, and self-assigned tasks.

Prospective memory (PM) involves remembering intended actions in the future, such as posting a letter when seeing a post box (event-based PM) or making a phone call at 2:00 pm (time-based PM). Studies on aging and PM have often reported negative age effects in the laboratory, but positive age effects in naturalistic tasks outside the laboratory (the so-called age-PM-paradox). The present study re-examined this pattern of the paradox by studying, for the first time, age differences in time- and event-based PM in lab-based, experimenter-generated naturalistic and self-assigned real-life PM tasks within the same sample of young and older adults. Results showed that differential age effects in and outside the laboratory were qualified by the type of PM cue. While age-related deficits were obtained for laboratory event-based tasks, no age effect was obtained for naturalistic event-based PM. Age benefits in the field were only observed for naturalistic time-based tasks, but not for participants' own self-assigned time-based tasks. These findings indicate that the age benefits for naturalistic PM tasks may have been overestimated due to the dominant use of experimenter-generated naturalistic time-based PM tasks in previous studies. Therefore, the precise pattern of the age-PM-paradox may need redefining as mostly consisting of negative age effects in lab-based PM tasks and mostly the absence of negative age effects (rather than age benefits) in naturalistic and self-assigned tasks outside the laboratory.

Episodic future thinking together with observational learning benefits prospective memory in high-functioning Korsakoff's syndrome patients.

OBJECTIVE: Patients with Korsakoff's syndrome (KS) have difficulty carrying out tasks which rely on prospective memory (PM). Since remembering to carry out an action in the future is crucial for living independently, it is of primary interest to develop strategies that improve PM performance in KS patients. DESIGN: The study employed a computer categorization task as an ongoing activity into which a PM task was embedded. We included episodic future thinking (EFT) and observational learning (Experiment 2) to boost PM. METHODS: Experiment 1 evaluated the efficacy of EFT following written PM task instructions in ten KS patients. Due to floor-level PM performance in Experiment 1, Experiment 2 included an instructional video demonstrating the PM intention. In Experiment 2, twenty-six KS patients performed both conditions (EFT and no-EFT) at least 1 week apart, while twelve controls with alcohol use disorder without KS performed the no-EFT condition. In Experiment 2, the PM instructions were also shown through video (observational learning component). Mild cognitive impairment was assessed in a short test battery. RESULTS: Experiment 1 showed overall floor performance in both conditions. Experiment 2 showed that KS patients performed PM tasks less accurately than the control group in the no-EFT condition. In Experiment 2, where the observational learning component was included, EFT improved PM performance in KS patients. This effect was driven by a sub-group of high-functioning KS patients. CONCLUSIONS: This study showed the value of an observational learning component together with EFT in improving PM performance, in relatively high-functioning KS patients. PRACTITIONER POINTS: KS patients performed the PM task less accurately than non-KS controls with alcohol use disorder, confirming PM impairment in this patient population. Controls with alcohol use disorder performed the PM task at ceiling level. Showing an instructional video demonstrating the PM intention improved PM performance and later recall of PM task instructions in KS patients. Episodic future thinking strategy improved PM performance in KS patients with relatively intact cognitive functioning.

Effects of sleep on the realization of complex plans.

Sleep consolidates newly encoded memories, particularly those memories that are relevant for future behaviour. This study explored whether sleep facilitates the successful execution of relatively complex plans in the future. We applied the Dresden Breakfast Task, in which subjects are instructed to prepare a virtual breakfast comprising several tasks (e.g. table-setting, preparing eggs). After forming a detailed plan how to realize these tasks, the sleep group (n = 17) spent a night of sleep at home, monitored by polysomnography, and the wake group (n = 19) spent a normal day awake, monitored by actigraphy. After a 12-h interval, all participants were asked to prepare the virtual breakfast. Contrary to our hypothesis, overall performance in breakfast preparation did not differ significantly between the sleep and wake groups. However, sleep participants performed better in one of six tasks, specifically the 'table-setting' task (P < 0.01), which was driven by higher scores in a subtask measuring the correct position of the tableware (P < 0.01). Additional exploratory analyses revealed that a significant number of wake participants performed below the minimal score of the sleep group (P < 0.01) and sleep participants achieved the maximal score in significantly more subtasks than wake participants (57% versus 27%; P = 0.018). Plan adherence, assessing how well participants adhered to their own previously developed plan, did not differ between the sleep and wake groups. These findings provide the first evidence that sleep may support some aspects of the realization of complex, somewhat naturalistic plans.

Smartwatch aids time-based prospective memory in Korsakoff syndrome: a case study.

Prospective memory (PM) is the ability to remember to carry out an intention in the future. PM is particularly impaired in Korsakoff syndrome (KS). We investigated the benefit of a smartwatch and smartphone compared to no aid in supporting time accuracy and PM task performance in KS. Time accuracy was improved with a smartwatch compared to the other conditions. Furthermore, the smartwatch and phone conditions were more effective than no aid in assisting memory for task content. Together these results suggest that using an external memory aid is beneficial for successful PM in KS.

Contextual recruitment of cognitive control in preadolescent children and young adults.

The ability to use contextual cues to adjust cognitive control according to situational demands is a hallmark of flexible and adaptive behavior. We investigated the development of three different types of contextual control recruitment in children (9- and 12-year-olds) and young adults. First, we implemented a list-wide proportion congruence manipulation in which conflict trials were frequently/infrequently presented within a list of trials. Second, we implemented a location-specific proportion congruence manipulation in which conflict trials were frequently/infrequently presented at one of two locations. Both types of contextual control recruitment are based on the formation of high-level associations between context features (lists and locations) and the respective cognitive control set. Contextual recruitment of control is observed in reduced interference at contexts with high conflict frequencies. Finally, we investigated a trial-by-trial, conflict-triggered recruitment of cognitive control. Here, the experience of a conflict in the previous trial is expected to reduce subsequent conflict. In all three forms of control recruitment, distinct contextual cues reveal information about the required extent of cognitive control. Young adults showed reliable adjustments of control for all types of contextual cues. Children were able to demonstrate contextual control recruitment based on stable context-control associations (lists and locations). However, using single conflict signals turned out to challenge children in that they were able to adapt control resources only for error reduction, not for reaction times. Altogether, the results indicated that children can learn and use high-level associations between context and control sets. Implications regarding proactive and reactive mechanisms of cognitive control are discussed.

The development of multitasking in children aged 7-12years: Evidence from cross-sectional and longitudinal data.

This study investigated the development of multitasking ability across childhood. A sample of 65 typically developing children aged 7, 9, and 11years completed two multitasking tests across three time points within a year. Cross-sectional and longitudinal data consistently indicated continuous linear growth in children's multitasking ability. By the age of 12years, children could effectively perform a simple multitasking scenario comprising six equally important tasks, although their ability to strategically organize assorted tasks with varied values and priorities in a complex multitasking setting had not reached proficiency yet. Cognitive functions underlying a complex multitasking scenario varied in their developmental trajectories. Retrospective memory developed continuously from 7 to 12years of age, suggesting its supporting role in the development of multitasking. Planning skills developed slowly and showed practice effects for older children but not for younger children. The ability to adhere to plans also developed slowly, and children of all age groups benefited from practice. This study offers a preliminary benchmark for future comparison with clinical populations and may help to inform the development of targeted interventions.

Salient cues improve prospective remembering in Korsakoff's syndrome.

OBJECTIVE: Korsakoff's syndrome is characterized by deficits in episodic memory and executive functions. Both cognitive functions are needed to remember to execute delayed intentions (prospective memory, PM), an ability that is crucial for independent living in everyday life. So far, PM has only been targeted by one study in Korsakoff's syndrome. This study explored the effects of executive control demands on PM to shed further light on a possible interdependence of memory and executive functions in Korsakoff's syndrome, METHOD: Twenty-five individuals with Korsakoff's syndrome and 23 chronic alcoholics (without amnesia) performed a categorization task into which a PM task was embedded that put either high or low demands on executive control processes (using low vs. high salient cues). RESULTS: Overall, Korsakoff patients had fewer PM hits than alcoholic controls. Across groups, participants had fewer PM hits when cues were low salient as compared to high salient. Korsakoff patients performed better on PM when highly salient cues were presented than cues of low salience, while there were no differential effects for alcoholic controls. CONCLUSIONS: While overall Korsakoff patients' showed a global PM deficit, the extent of this deficit was moderated by the executive control demands of the task applied. This indicated further support for an interrelation of executive functions and memory performance in Korsakoff. PRACTITIONER POINTS: Positive clinical implications of the work Prospective memory (PM) performance in Korsakoff's syndrome is related to executive control load. Increasing cues' salience improves PM performance in Korsakoff's syndrome. Salient visual aids may be used in everyday life to improve Korsakoff individuals' planning and organization skills. Cautions or limitations of the study Results were obtained in a structured laboratory setting and need to be replicated in a more naturalistic setting to assess their transferability to everyday life. Given the relatively small sample size, individual predictors of PM performance should be determined in larger samples.

Theory of mind and switching predict prospective memory performance in adolescents.

Research indicates ongoing development of prospective memory as well as theory of mind and executive functions across late childhood and adolescence. However, so far the interplay of these processes has not been investigated. Therefore, the purpose of the current study was to investigate whether theory of mind and executive control processes (specifically updating, switching, and inhibition) predict prospective memory development across adolescence. In total, 42 adolescents and 41 young adults participated in this study. Young adults outperformed adolescents on tasks of prospective memory, theory of mind, and executive functions. Switching and theory of mind predicted prospective memory performance in adolescents.

A Virtual Week study of prospective memory function in autism spectrum disorders.

Prospective memory (PM) refers to the implementation of delayed intentions, a cognitive ability that plays a critical role in daily life because of its involvement in goal-directed behavior and consequently the development and maintenance of independence. Emerging evidence indicates that PM may be disrupted in autism spectrum disorders (ASDs), potentially contributing to the functional difficulties that characterize this group. However, the degree, nature, and specificity of ASD-related impairment remains poorly understood. In the current study, children between 8 and 12 years of age who were diagnosed with ASDs (n=30) were compared with typically developing children (n=30) on a child-appropriate version of the Virtual Week board game. This measure provides an opportunity to investigate the different sorts of PM failures that occur. The ASD group showed significant PM impairment on measures of time-based (but not event-based) prospective remembering. However, only a subtle difference emerged between regular and irregular PM tasks, and group differences were consistent across these tasks. Because regular and irregular tasks differentially load retrospective memory, these data imply that the PM difficulties seen in ASDs may primarily reflect a monitoring deficit and not an encoding and memory storage deficit. PM performance was poorer under conditions of high ongoing task absorption, but the magnitude of this effect did not vary as a function of group. In both groups, time-based (but not event-based) PM difficulties were associated with functional outcomes in daily life, but only an inconsistent association with executive control emerged.

Practice is the best of all instructors-Effects of enactment encoding and episodic future thinking on prospective memory performance in high-functioning adults with autism spectrum disorder.

Prospective memory (PM) is the ability to remember to carry out intended actions in the future. The present study investigated the effects of episodic future thinking (EFT) and enactment encoding (EE) on PM performance in autistic adults (ASD). A total of 72 autistic individuals and 70 controls matched for age, gender, and cognitive abilities completed a computerized version of the Dresden breakfast Task, which required participants to prepare breakfast following a set of rules and time restrictions. A two (group: ASD vs. controls) by three (encoding condition: EFT vs. EE vs. standard) between-subjects design was applied. Participants were either instructed to engage in EFT or EE to prepare to the different tasks prior to performing the Dresden breakfast or received standard instructions. Analyses of variance were conducted. Autism-spectrum-disorders (ASD) participants did not differ from control participants in their PM performance, regardless of which strategy they used. Compared to the standard condition, EE but not EFT improved time-based PM performance in all participants. This is the first study to find spared time-based PM performance in autistic individuals. The results confirm earlier results of beneficial effects of EE on PM performance. Findings are discussed with regards to the methodology used, sample composition as well as autistic characteristics.

A matter of precision? Scene imagery in individuals with high-functioning autism spectrum disorder.

The ability to create mental representations of scenes is essential for remembering, predicting, and imagining. In individuals with autism spectrum disorders (ASD) this ability may be impaired. Considering that autistic characteristics such as weak central coherence or reduced communication abilities may disadvantage autistic participants in traditional imagery tasks, this study attempted to use a novel task design to measure the ability of scene imagery. Thirty high-functioning adults with ASD and 27 non-autistic matched control adults were asked to describe imagined fictitious scenes using two types of scene imagery tasks. In a free imagery task, participants were asked to imagine a scene based on a given keyword. In a guided imagery task, participants had to imagine a scene based on a detailed description of the scene. Additionally, narrative abilities were assessed using the Narrative Scoring Scheme. Statistical analyses revealed no group effects in the free and guided imagery of fictional scenes. Participants with ASD performed worse than control participants in the narrative task. Narrative abilities correlated positively with performance in both imagery tasks in the ASD group only. Hence, individuals with ASD seem to show as good imagery abilities as non-autistic individuals. The results are discussed in the light of the differences between imagery and imagination and possible gender differences.

Remembering the future; prospective memory across the autistic adult's life span.

LAY ABSTRACT: What is already known: Prospective memory is an important function for daily living. It is the cognitive function that helps you remember that you are meeting your friend for coffee at 2 pm tomorrow, or that you need to take your vitamins after breakfast. This cognitive function is particularly important in autistic adults, but how prospective memory is associated with increasing age, we currently do not know.What this paper adds: Although performance on experimental tasks that measure prospective memory decreases with age, this pattern is similar in autistic and non-autistic adults. No age effects were found for tasks that were performed outside the lab. Autistic adults and non-autistic adults perform similarly on prospective memory, and this performance remains similar when autistic and non-autistic adults age.Implications for practice, research, or policy: While our results show that prospective memory decreased with increasing age, our results do point to parallel development of prospective memory in autistic and non-autistic adults. This finding serves as a reassurance for those individuals concerned that older autistic individuals might show quicker cognitive decline.

The Advanced BRain Imaging on ageing and Memory (ABRIM) data collection: Study design, data processing, and rationale.

To understand the neurocognitive mechanisms that underlie heterogeneity in cognitive ageing, recent scientific efforts have led to a growing public availability of imaging cohort data. The Advanced BRain Imaging on ageing and Memory (ABRIM) project aims to add to these existing datasets by taking an adult lifespan approach to provide a cross-sectional, normative database with a particular focus on connectivity, myelinization and iron content of the brain in concurrence with cognitive functioning, mechanisms of reserve, and sleep-wake rhythms. ABRIM freely shares MRI and behavioural data from 295 participants between 18-80 years, stratified by age decade and sex (median age 52, IQR 36-66, 53.20% females). The ABRIM MRI collection consists of both the raw and pre-processed structural and functional MRI data to facilitate data usage among both expert and non-expert users. The ABRIM behavioural collection includes measures of cognitive functioning (i.e., global cognition, processing speed, executive functions, and memory), proxy measures of cognitive reserve (e.g., educational attainment, verbal intelligence, and occupational complexity), and various self-reported questionnaires (e.g., on depressive symptoms, pain, and the use of memory strategies in daily life and during a memory task). In a sub-sample (n = 120), we recorded sleep-wake rhythms using an actigraphy device (Actiwatch 2, Philips Respironics) for a period of 7 consecutive days. Here, we provide an in-depth description of our study protocol, pre-processing pipelines, and data availability. ABRIM provides a cross-sectional database on healthy participants throughout the adult lifespan, including numerous parameters relevant to improve our understanding of cognitive ageing. Therefore, ABRIM enables researchers to model the advanced imaging parameters and cognitive topologies as a function of age, identify the normal range of values of such parameters, and to further investigate the diverse mechanisms of reserve and resilience.

Prospective memory in schizophrenia and schizotypy.

INTRODUCTION: Most evidence suggests that schizophrenia is associated with pervasive prospective memory (PM) impairment that does not vary as a function of task demands. However, a central tenet of the Multiprocess Framework is that PM involves both automatic and strategic processes, and that their relative prominence varies as a function of PM task characteristics, such as target-cue saliency. METHODS: Participants with schizophrenia (n = 30), matched controls (n = 29), low schizotypes (n = 35), and high schizotypes (n = 36) were administered a PM measure in which saliency was manipulated. To further clarify the relationship between PM and schizotypy, high and low schizotypies were additionally assessed on Virtual Week, a laboratory measure which has documented sensitivity to schizophrenia-related impairment. RESULTS: Relative to controls, participants with schizophrenia exhibited PM difficulties, but the magnitude of this deficit did not vary as a function of target-cue saliency. High and low schizotypes did not differ on any PM test parameter. CONCLUSIONS: These data are consistent with other evidence showing that schizophrenia is characterised by generalised PM impairment. However, the absence of any schizotypy effects on PM does not support the recent suggestion that PM may represent an endophenotype for schizophrenia.

Do emotionally salient cues improve prospective memory performance in children and adolescents with autism?

BACKGROUND: Prospective memory (PM) describes the ability to initiate and perform a planned action after a delay. Previous studies suggest reduced PM in autism spectrum disorder (ASD); especially when tasks put high demands on executive control resources. Increasing cue salience by presenting emotional cues improves PM performance in non-autistic populations. AIMS: To explore whether children with ASD, whose processing of emotionally connoted information might differ from that of typically developing children, may also benefit from this type of salience in PM tasks. METHODS AND PROCEDURES: Twenty-five children with and 25 children without ASD completed a 1-back ongoing task into which an event-based PM task was embedded. Emotional salience of PM cues was varied. OUTCOMES AND RESULTS: Children with ASD performed as well as children without ASD on the PM task and equally benefited from emotionally salient cues. Specifically, negative cues increased PM performance compared to neutral cues in both groups CONCLUSIONS AND IMPLICATIONS: The findings are consistent with the multiprocess framework which postulates that salient PM cues increase performance by promoting automatic intention retrieval and reducing executive control demands. Children with ASD seem to show similar comprehension and accessibility to emotional cues as typically developing children.

The Effects of Separate Facial Areas on Emotion Recognition in Different Adult Age Groups: A Laboratory and a Naturalistic Study.

The identification of facial expressions is critical for social interaction. The ability to recognize facial emotional expressions declines with age. These age effects have been associated with differential age-related looking patterns. The present research project set out to systematically test the role of specific facial areas for emotion recognition across the adult lifespan. Study 1 investigated the impact of displaying only separate facial areas versus the full face on emotion recognition in 62 younger (20-24 years) and 65 middle-aged adults (40-65 years). Study 2 examined if wearing face masks differentially compromises younger (18-33 years, N = 71) versus middle-aged to older adults' (51-83 years, N = 73) ability to identify different emotional expressions. Results of Study 1 suggested no general decrease in emotion recognition across the lifespan; instead, age-related performance seems to depend on the specific emotion and presented face area. Similarly, Study 2 observed only deficits in the identification of angry, fearful, and neutral expressions in older adults, but no age-related differences with regards to happy, sad, and disgusted expressions. Overall, face masks reduced participants' emotion recognition; however, there were no differential age effects. Results are discussed in light of current models of age-related changes in emotion recognition.

Correction: Protocol of the Healthy Brain Study: An accessible resource for understanding the human brain and how it dynamically and individually operates in its bio-social context.

[This corrects the article DOI: 10.1371/journal.pone.0260952.].

To do or not to do? Prospective memory versus response inhibition in autism spectrum disorder and attention-deficit/hyperactivity disorder.

In the present research, event-based prospective memory and response inhibition (RI) abilities were investigated in children with ASD (Study 1), with ADHD (Study 2), and their matched neurotypical controls. Children engaged in a categorisation (ongoing) task and, concurrently, in either an event-based prospective memory (PM) or a Go/No-Go secondary task. Results showed that, as compared to their matched controls, ASD children's performance was more impaired in the PM task than in the Go/No-Go task, while the performance pattern of ADHD children was reversed. In the ongoing task, ASD children were as accurate as, but significantly slower than, controls, independently of conditions. ADHD children did not differ from controls in the presence of a concurrent PM task, while they were less accurate than controls in the presence of the go/no-go task. Overall, the two patterns of findings suggest important differences in the way ASD and ADHD children remember and realise intentions requiring opposite behaviours (acting vs stopping).

Prospective memory, emotional valence and ageing.

Emotional factors have been found to be an important influence on memory. The current study investigated the influence of emotional salience and age on a laboratory measure of prospective memory (PM); Virtual Week. Thirty young and 30 old adults completed Virtual Week, in which the emotional salience of the tasks at encoding was manipulated to be positive, negative or neutral in content. For event-based, but not time-based tasks, positivity enhancement in both age groups was seen, with a greater number of positive PM tasks being performed relative to neutral tasks. There was no negativity enhancement effect. Older adults showed generally poorer levels of PM, but they also demonstrated greater beneficial effects of positive valence compared to young. These effects of emotion on PM accuracy do not appear to reflect the retrospective component of the task as a different pattern of emotion effects was seen on the recall of PM content. Results indicate that older adults' difficulties in prospective remembering can be reduced where the tasks to be remembered are positive.