Detalhe da pesquisa
1.
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease.
Arch Pharm (Weinheim)
; 357(3): e2300491, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38158335
2.
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity.
Int J Mol Sci
; 24(9)2023 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37175433
3.
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors.
Molecules
; 28(4)2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36838649
4.
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity.
Molecules
; 28(15)2023 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37570828
5.
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors.
Mol Divers
; 26(2): 1243-1247, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33538985
6.
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases.
Molecules
; 27(13)2022 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35807514
7.
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity.
Molecules
; 27(19)2022 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36234811
8.
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.
Molecules
; 26(17)2021 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500640
9.
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential.
Molecules
; 26(2)2021 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33445600
10.
Reductive domino reaction to access chromeno[2,3-c]isoquinoline-5-amines with antiproliferative activities against human tumor cells.
Bioorg Chem
; 104: 104169, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32920352
11.
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease.
Molecules
; 25(23)2020 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33297547
12.
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats.
Mol Pharm
; 14(9): 3178-3187, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28780872
13.
A second life for MAO inhibitors? From CNS diseases to anticancer therapy.
Eur J Med Chem
; 267: 116180, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38290352
14.
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics.
Antioxidants (Basel)
; 13(1)2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38275658
15.
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults.
Eur J Med Chem
; 270: 116353, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579622
16.
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance.
Pharmaceuticals (Basel)
; 17(4)2024 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675499
17.
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
ACS Chem Neurosci
; 15(5): 955-971, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38372253
18.
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology.
Methods Mol Biol
; 2558: 207-220, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36169866
19.
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase.
Chem Biol Interact
; 386: 110741, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37839515
20.
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.
RSC Med Chem
; 13(7): 873-883, 2022 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35923722