Detalhe da pesquisa
1.
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
Cell Microbiol
; 16(8): 1267-83, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24612080
2.
Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.
Proc Natl Acad Sci U S A
; 109(28): 11144-9, 2012 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22733743
3.
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain.
Nat Chem Biol
; 8(10): 823-30, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22902615
4.
XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies.
Mol Cancer Ther
; 23(4): 421-435, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38030380
5.
Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI.
Biochemistry
; 51(14): 3079-91, 2012 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22432862
6.
Aminobenzoates as building blocks for natural product assembly lines.
Nat Prod Rep
; 29(1): 37-59, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22064917
7.
Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.
Biochemistry
; 50(24): 5401-3, 2011 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21615132
8.
Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway.
Biochemistry
; 50(39): 8392-406, 2011 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21870821
9.
Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.
Biochemistry
; 50(25): 5668-79, 2011 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21591693
10.
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.
Biochemistry
; 50(40): 8756-69, 2011 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21899262
11.
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.
J Am Chem Soc
; 133(8): 2729-41, 2011 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21299212
12.
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
Proc Natl Acad Sci U S A
; 105(14): 5349-54, 2008 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18388203
13.
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.
Biochemistry
; 49(39): 8564-76, 2010 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20804163
14.
Anthranilate-activating modules from fungal nonribosomal peptide assembly lines.
Biochemistry
; 49(15): 3351-65, 2010 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20225828
15.
Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.
ACS Chem Biol
; 8(7): 1366-82, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659680
16.
Structural enzymology of polyketide synthases.
Methods Enzymol
; 459: 17-47, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19362634
17.
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
Appl Environ Microbiol
; 72(4): 2573-80, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16597959