Detalhe da pesquisa
1.
Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat.
J Pharmacol Exp Ther
; 386(1): 26-34, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37068911
2.
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.
Toxicol Pathol
; 51(1-2): 15-26, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37078689
3.
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.
Nat Immunol
; 9(6): 613-22, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18469817
4.
Structure Guided Discovery of Novel Pan Metallo-ß-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J Med Chem
; 67(5): 3400-3418, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387069
5.
Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.
Proc Natl Acad Sci U S A
; 106(2): 522-7, 2009 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19116268
6.
Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor.
Toxicol Sci
; 185(2): 170-183, 2022 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34897513
7.
Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.
J Med Chem
; 65(7): 5575-5592, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35349275
8.
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
J Med Chem
; 65(1): 485-496, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34931831
9.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704436
10.
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
J Med Chem
; 64(18): 13215-13258, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375108
11.
A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model.
J Immunotoxicol
; 17(1): 175-185, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33078980
12.
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J Med Chem
; 63(22): 13796-13824, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170686
13.
Translational Safety Biomarkers of Kidney Injury.
Semin Nephrol
; 39(2): 202-214, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30827342
14.
Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3.
Toxicol Sci
; 172(1): 155-166, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31406999
15.
Oxidative stress and its role in skin disease.
Antioxid Redox Signal
; 4(4): 665-73, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12230879
16.
Identification of platform-independent gene expression markers of cisplatin nephrotoxicity.
Environ Health Perspect
; 112(4): 488-94, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15033599
17.
Overview on the application of transcription profiling using selected nephrotoxicants for toxicology assessment.
Environ Health Perspect
; 112(4): 460-4, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15033596
18.
Identification of putative gene based markers of renal toxicity.
Environ Health Perspect
; 112(4): 465-79, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15033597
19.
ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.
Radiat Res
; 160(3): 273-90, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12926986
20.
Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes.
Toxicol Sci
; 69(2): 306-16, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12377979