Detalhe da pesquisa
1.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411795
2.
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Bioorg Med Chem Lett
; 23(24): 6588-92, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239482
3.
De novo lipogenesis is essential for platelet production in humans.
Nat Metab
; 2(10): 1163-1178, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929234
4.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092695
5.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853885
6.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
J Med Chem
; 57(24): 10512-26, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25423286
7.
The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.
PLoS One
; 9(5): e97139, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24858947
8.
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.
J Med Chem
; 56(17): 7110-9, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23981033
9.
Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
J Med Chem
; 55(2): 935-42, 2012 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148323