Detalhe da pesquisa
1.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
; 618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225977
2.
Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.
J Antimicrob Chemother
; 70(6): 1691-703, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25656411
3.
Structure-activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling.
Sci Rep
; 14(1): 3447, 2024 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38342953
4.
Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A.
Redox Biol
; 44: 101978, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33903070
5.
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
J Med Chem
; 64(7): 3658-3676, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33729773
6.
Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology.
ACS Med Chem Lett
; 11(5): 991-999, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32435416
7.
Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models.
ACS Med Chem Lett
; 11(8): 1634-1644, 2020 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32832034
8.
Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open
; 8(1)2019 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30602529
9.
Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry.
Viruses
; 11(2)2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30791609
10.
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
Bioorg Med Chem Lett
; 18(1): 318-23, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18006306
11.
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Bioorg Med Chem Lett
; 18(15): 4433-7, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18602262
12.
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.
Bioorg Med Chem Lett
; 18(15): 4428-32, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614366
13.
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.
Bioorg Med Chem Lett
; 18(1): 324-8, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17981461
14.
Progress towards a public chemogenomic set for protein kinases and a call for contributions.
PLoS One
; 12(8): e0181585, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28767711
15.
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.
Protein Sci
; 15(4): 774-84, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16522804
16.
The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors.
Protein Sci
; 23(6): 723-34, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24639329
17.
Development of a fluorescence intensity assay for the mitotic serine/threonine protein kinase Aurora-A.
J Biomol Screen
; 18(2): 219-25, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22983166
18.
The prophylaxis and treatment with antiviral agents of respiratory syncytial virus infections.
Antivir Chem Chemother
; 22(4): 139-50, 2012 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22182737
19.
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
Bioorg Med Chem Lett
; 17(5): 1296-301, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194588
20.
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Bioorg Med Chem Lett
; 17(15): 4363-8, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17600705