Detalhe da pesquisa
1.
The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia.
J Pediatr
; 216: 150-157.e1, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31635813
2.
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.
Pediatr Blood Cancer
; 61(5): 797-802, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24395436
3.
Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia.
Eur J Clin Pharmacol
; 69(9): 1641-9, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23660772
4.
Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT*2 and TPMT*5.
Biochemistry
; 51(30): 5912-20, 2012 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22747506
5.
Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism.
Basic Clin Pharmacol Toxicol
; 128(1): 52-65, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865889
6.
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Cancer Chemother Pharmacol
; 88(2): 271-279, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33928426
7.
Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene.
Pharmacogenet Genomics
; 20(11): 700-7, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20881512
8.
Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden.
Biochem Pharmacol
; 164: 263-272, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31005613
9.
Role of TPMT and ITPA variants in mercaptopurine disposition.
Cancer Chemother Pharmacol
; 81(3): 579-586, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29387964
10.
One amino acid makes a difference-Characterization of a new TPMT allele and the influence of SAM on TPMT stability.
Sci Rep
; 7: 46428, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462921
11.
Interconnections between apoptotic and autophagic pathways during thiopurine-induced toxicity in cancer cells: the role of reactive oxygen species.
Oncotarget
; 7(46): 75616-75634, 2016 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689330
12.
Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells.
J Chromatogr B Analyt Technol Biomed Life Sci
; 939: 80-5, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24113235
13.
A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol.
J Crohns Colitis
; 7(6): 510-3, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23168376
14.
Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function.
J Crohns Colitis
; 6(6): 655-9, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22398041