RESUMO
Antibodies of all four dengue virus serotypes were detected by hemagglutination inhibition (HI) in 97% of 2,000 infants' cord sera at the time of delivery. In comparison with 250 mother-infant's paired sera, we found that 53% of the infants' serum HI titers were higher than those of the mother's. The mother/infant IgG subclasses 1, 2, 3, and 4 titers were 53.1/87.0, 8.4/11.7, 0.14/0.11, and 1.1/1.0 mg/dL, respectively. In 18 months of follow-up of 100 infants studied, we observed that antibody to dengue virus disappeared in 3% by two months of age, in 19% by four months of age, in 72% by six months of age, in 99% by nine months of age, and in 100% by 12 months of age, with a half-life of 41 days. We conclude that the antibodies to dengue virus disappeared in the first year of life. We suggest that the most appropriate age for vaccination with a live-attenuated dengue vaccine in an endemic area is one year of age.
Assuntos
Anticorpos Antivirais/imunologia , Vírus da Dengue/imunologia , Imunidade Materno-Adquirida , Dengue Grave/imunologia , Adolescente , Adulto , Anticorpos Antivirais/sangue , Western Blotting , Vírus da Dengue/classificação , Feminino , Sangue Fetal/virologia , Testes de Inibição da Hemaglutinação , Humanos , Esquemas de Imunização , Recém-Nascido , Pessoa de Meia-Idade , Gravidez , Dengue Grave/prevenção & controle , Vacinas Virais/administração & dosagemAssuntos
Infecções por HIV/complicações , Anticorpos Anti-Hepatite B/sangue , Vacinas contra Hepatite B/administração & dosagem , Vacinas contra Hepatite B/imunologia , Hepatite B/prevenção & controle , Feminino , Vacinas contra Hepatite B/genética , Vírus da Hepatite B/imunologia , Humanos , Esquemas de Imunização , Lactente , Recém-Nascido , Masculino , Vacinas Sintéticas/administração & dosagem , Vacinas Sintéticas/imunologiaRESUMO
Antibodies to chikungunya virus were detected by hemagglutination-inhibition assay in 33.6% of 2,000 infants' cord sera at delivery. Follow-up of 24 seropositive infants showed that the half-life of antibody persistence was 35.5 days. Chikungunya virus infection is common in Thailand, and routine use of diagnostic assays is needed.