Detalhe da pesquisa
1.
Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.
Pharmacol Rev
; 71(4): 539-570, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31537750
2.
Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).
Biochem J
; 476(10): 1553-1570, 2019 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31072910
3.
Developing kinase inhibitors for malaria: an opportunity or liability?
Trends Parasitol
; 39(9): 720-731, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37385921
4.
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.
Br J Pharmacol
; 180(15): 1899-1929, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197802
5.
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.
J Med Chem
; 65(4): 3371-3387, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35113565
6.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Sci Transl Med
; 14(667): eabo7219, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260689
7.
Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities.
ACS Infect Dis
; 7(3): 518-534, 2021 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33590753
8.
Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension.
Hypertension
; 78(3): 604-616, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34304582
9.
New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase.
ACS Infect Dis
; 7(1): 34-46, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33319990
10.
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.
ACS Infect Dis
; 6(11): 3048-3063, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32966036
11.
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
Cell Chem Biol
; 27(7): 806-816.e8, 2020 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32359426
12.
Effects of polymorphic variation on the thermostability of heterogenous populations of CYP3A4 and CYP2C9 enzymes in solution.
Sci Rep
; 8(1): 11876, 2018 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30089838
13.
Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.
J Med Chem
; 61(22): 10141-10154, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30372620