Detalhe da pesquisa
1.
Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT.
Chem Res Toxicol
; 33(2): 625-633, 2020 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31841318
2.
Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 1): 68-78, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24419380
3.
Gastric coinfection with thiopeptide-positive Cutibacterium acnes decreases FOXM1 and pro-inflammatory biomarker expression in a murine model of Helicobacter pylori-induced gastric cancer.
Microbiol Spectr
; 12(1): e0345023, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38014984
4.
Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents.
NAR Cancer
; 5(2): zcad015, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36992846
5.
Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice.
Cell Rep
; 34(11): 108864, 2021 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33730582
6.
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
J Med Chem
; 57(22): 9480-94, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25341194
7.
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
J Exp Med
; 211(3): 473-86, 2014 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24567448
8.
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J Med Chem
; 56(17): 6696-708, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23947754
9.
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
J Exp Med
; 209(12): 2215-28, 2012 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23148236