Detalhe da pesquisa
1.
Evaluation of in vitro antiviral activity of SARS-CoV-2 Mpro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions.
Antimicrob Agents Chemother
; 67(11): e0084023, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37800975
2.
Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.
PLoS Pathog
; 16(11): e1008593, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33180834
3.
A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human ß-Tryptase.
Pharmacology
; 102(5-6): 233-243, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30134249
4.
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
J Med Chem
; 67(3): 1747-1757, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38230963
5.
Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
J Med Chem
; 67(3): 1734-1746, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38267212
6.
Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.
Bioorg Med Chem Lett
; 21(7): 2092-7, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353551
7.
Novel, Self-Assembling Dimeric Inhibitors of Human ß Tryptase.
J Med Chem
; 63(6): 3004-3027, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32057241
8.
OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models.
Cancer Res
; 66(2): 1015-24, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16424037
9.
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.
Mol Cancer Ther
; 6(8): 2158-67, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17671083
10.
Target-Directed Self-Assembly of Homodimeric Drugs Against ß-Tryptase.
ACS Med Chem Lett
; 9(8): 827-831, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128075
11.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
12.
Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.
PLoS One
; 10(4): e0121793, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25875098
13.
Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in rats.
Restor Neurol Neurosci
; 22(2): 73-9, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15272142
14.
Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.
Mol Cancer Ther
; 10(8): 1394-406, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21673091
15.
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.
Future Med Chem
; 1(6): 1153-71, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21425998
16.
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
Bioorg Med Chem Lett
; 16(16): 4371-5, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16750628
17.
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 16(16): 4266-71, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759855
18.
A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules.
Bioorg Med Chem Lett
; 14(22): 5503-7, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15482913