Assuntos
Neoplasias da Mama/diagnóstico por imagem , Mamilos , Doença de Paget Mamária/diagnóstico por imagem , Dermatopatias/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/patologia , Dermoscopia , Diagnóstico Diferencial , Eczema/diagnóstico por imagem , Feminino , Humanos , Masculino , Microscopia Confocal , Pessoa de Meia-Idade , Doença de Paget Mamária/patologia , Estudos Retrospectivos , Sensibilidade e Especificidade , Dermatopatias/patologiaRESUMO
BACKGROUND: Accidental extravasation of anthracyclines might result in devastating side effects and complications, including necrosis of tissue, with impairment of neighboring structures - most of them requiring surgery. Following recent approach guidelines, intravenous administration of dexrazoxane within 6 h after the event is recommended. CASE REPORT: We report on a 63-year-old female patient with breast cancer treated with epirubicin combination therapy. She experienced extravasation on the distal right arm at the end of the very first cycle, being initially treated with dimethylsulfoxide 99% topically. Clinical symptoms became worse. Despite the interval between the event and referral, dexrazoxane was given once daily for 3 days. She recovered completely without any sequelae. CONCLUSION: To our knowledge, this is the first case report of a successful treatment and complete recovery by the use of dexrazoxane even 3 days after extensive epirubicin extravasation. Additionally, a review of the literature is given.