An autopsy survey of hepatitis B in Sydney.

AIM: 1) To determine the prevalence of hepatitis B in Sydney autopsies and 2) to determine the relationship between seroprevalence, hepatitis B risk factors and histological changes in the liver. METHODS: One hundred autopsy subjects were studied for evidence of past or present hepatitis B infection, using RIA to detect the HBV antigens and antibodies in the serum and peroxidase-antiperoxidase technique to detect HBsAg and HBcAg in the liver. Both serum and liver were examined for the presence of HBV DNA. RESULTS: Markers of hepatitis B virus infection were detected in either serum and/or liver of 29 subjects. Four subjects (4%) were seropositive for HBsAg. Eight subjects had been recently infected, 7 were chronically infected and 14 had recovered. CONCLUSION: The 29% prevalence of HBV infection is higher than expected. In four cases the serum was either free of HBV markers or showed conventional evidence of recovery, yet the liver still contained HBsAg. There were few histopathological changes despite the presence of HBsAg in the liver. The only epidemiological factors possibly predisposing to HBV infection were tattooing and drug abuse.

Viral meningitis due to echovirus types 6 and 9: epidemiological data from Western Australia.

During the autumn of 1992, Western Australia experienced a large viral meningitis outbreak of dual aetiology. Of the 161 cases, 64% were children under 15 years of age, with the highest notification rate being in children less than 5 years of age. Echovirus 9 caused 41% of cases and occurred mainly in the metropolitan areas of Western Australia whereas echovirus 6, which caused 37% of cases, was more widespread. An enterovirus was cultured from 70% of CSF specimens, 88% of faecal specimens and 68% of upper respiratory tract specimens. High CSF white cell counts and neutrophil predominance were common. Seven cases had normal CSF white cell counts even though an enterovirus was isolated from the CSF. Therefore, the CSF findings were of restricted value in excluding viral meningitis, and did not reliably distinguish between bacterial and viral meningitis.