Detalhe da pesquisa
1.
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor.
Proc Natl Acad Sci U S A
; 113(41): E6145-E6152, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671624
2.
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinase.
Bioorg Med Chem Lett
; 25(5): 1047-52, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25655723
3.
Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2.
J Immunol
; 187(7): 3840-53, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21880982
4.
CEP-26401 (irdabisant), a potent and selective histamine H3 receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities.
J Pharmacol Exp Ther
; 340(1): 124-33, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22001260
5.
Novel poly(ADP-ribose) polymerase-1 inhibitors.
Bioorg Med Chem Lett
; 22(1): 222-4, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153339
6.
Serendipity in discovery of proteasome inhibitors.
Bioorg Med Chem Lett
; 22(10): 3503-5, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22503349
7.
Wake-promoting agents: search for next generation modafinil: part II.
Bioorg Med Chem Lett
; 22(6): 2315-7, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22341942
8.
Wake-promoting agents: search for next generation modafinil: part I.
Bioorg Med Chem Lett
; 22(6): 2312-4, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22264475
9.
Wake promoting agents: search for next generation modafinil, lessons learned: part III.
Bioorg Med Chem Lett
; 22(11): 3751-3, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22546675
10.
Proteasome inhibitors for cancer therapy.
Bioorg Med Chem
; 20(7): 2362-8, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22377673
11.
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
ACS Chem Neurosci
; 13(6): 751-765, 2022 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35245037
12.
2,7-Disubstituted-pyrrolotriazine kinase inhibitors with an unusually high degree of reactive metabolite formation.
Chem Res Toxicol
; 24(11): 1994-2003, 2011 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22023349
13.
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Bioorg Med Chem Lett
; 21(7): 1991-6, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21376585
14.
Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.
Bioorg Med Chem Lett
; 21(1): 463-6, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074994
15.
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Bioorg Med Chem Lett
; 21(18): 5342-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21807507
16.
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
J Med Chem
; 63(14): 7906-7920, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32558564
17.
Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer.
J Med Chem
; 51(4): 1068-72, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18247547
18.
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment.
JCI Insight
; 2(21)2017 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29093271
19.
3-(1'-Cyclobutylspiro[4H-1,3-benzodioxine-2,4'-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist.
Neuropharmacology
; 106: 37-45, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26400408
20.
Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK).
J Med Chem
; 59(16): 7478-96, 2016 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527804