Detalhe da pesquisa
1.
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.
J Biol Chem
; 292(9): 3900-3908, 2017 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28077575
2.
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.
Nature
; 488(7409): 96-9, 2012 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801501
3.
Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.
J Biol Chem
; 289(45): 30990-1000, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25253696
4.
Spatially coordinated kinase signaling regulates local axon degeneration.
J Neurosci
; 32(39): 13439-53, 2012 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23015435
5.
An effector-reduced anti-ß-amyloid (Aß) antibody with unique aß binding properties promotes neuroprotection and glial engulfment of Aß.
J Neurosci
; 32(28): 9677-89, 2012 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22787053
6.
Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing.
Drug Metab Dispos
; 41(7): 1319-28, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23584887
7.
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
CPT Pharmacometrics Syst Pharmacol
; 12(1): 62-73, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36281062
8.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med
; 13(593)2021 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33980574
9.
Mechanistic Modeling of Soluble Aß Dynamics and Target Engagement in the Brain by Anti-Aß mAbs in Alzheimer's Disease.
Curr Alzheimer Res
; 17(4): 393-406, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32116192
10.
p63 is an essential proapoptotic protein during neural development.
Neuron
; 48(5): 743-56, 2005 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-16337913
11.
Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aß.
Alzheimers Res Ther
; 11(1): 97, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31787113
12.
Widespread brain distribution and activity following i.c.v. infusion of anti-ß-secretase (BACE1) in nonhuman primates.
Br J Pharmacol
; 174(22): 4173-4185, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28859225
13.
Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.
Eur J Pharm Biopharm
; 101: 53-61, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26820920
14.
Structure of Crenezumab Complex with Aß Shows Loss of ß-Hairpin.
Sci Rep
; 6: 39374, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27996029
15.
Characterization of a sensitive mouse Aß40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice.
Bioanalysis
; 8(10): 1067-75, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27094761
16.
Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse.
J Neurosci
; 23(20): 7602-9, 2003 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12930799
17.
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.
Sci Transl Med
; 6(261): 261ra154, 2014 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25378646
18.
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Nat Med
; 20(12): 1452-7, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25419706
19.
A therapeutic antibody targeting BACE1 inhibits amyloid-ß production in vivo.
Sci Transl Med
; 3(84): 84ra43, 2011 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21613622
20.
PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Science
; 322(5903): 967-70, 2008 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-18988857