Detalhe da pesquisa
1.
Effect of Aging and a Dual Orexin Receptor Antagonist on Sleep Architecture and Non-REM Oscillations Including an REM Behavior Disorder Phenotype in the PS19 Mouse Model of Tauopathy.
J Neurosci
; 43(25): 4738-4749, 2023 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37230765
2.
Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD.
Neurobiol Dis
; 179: 106050, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36809847
3.
Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Alzheimers Dement
; 17(2): 149-163, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33314529
4.
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease.
Acta Neuropathol
; 140(3): 295-315, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32666270
5.
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.
Mol Psychiatry
; 24(9): 1383-1397, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30283031
6.
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aß amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aß burden.
Mol Psychiatry
; 24(3): 431-446, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30283032
7.
Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aß amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aß burden.
Mol Psychiatry
; 24(3): 472, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30464330
8.
ßAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.
Cereb Cortex
; 28(11): 3976-3993, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29048465
9.
Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice.
Brain
; 140(3): 826-842, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28003243
10.
Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.
Hum Mol Genet
; 24(21): 5965-76, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26358780
11.
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Acta Neuropathol
; 134(5): 769-788, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28612290
12.
Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.
Acta Neuropathol
; 131(2): 247-266, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26538149
13.
Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework.
MAbs
; 15(1): 2232087, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37408314
14.
Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice.
bioRxiv
; 2023 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37662269
15.
Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF.
Brain Commun
; 5(6): fcad306, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38025276
16.
Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2.
Mol Neurodegener
; 17(1): 55, 2022 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36002854
17.
Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces ß-Amyloid Load in Males and Females.
Cells
; 11(23)2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36497141
18.
VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice.
Mol Neurodegener
; 15(1): 4, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31924226
19.
Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
Nat Commun
; 11(1): 3942, 2020 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32770063
20.
Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.
Acta Neuropathol Commun
; 7(1): 46, 2019 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30885273