Detalhe da pesquisa
1.
Multimodal small-molecule screening for human prion protein binders.
J Biol Chem
; 295(39): 13516-13531, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32723867
2.
Characterization and Use of TurboLuc Luciferase as a Reporter for High-Throughput Assays.
Biochemistry
; 57(31): 4700-4706, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29641191
3.
Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.
J Biol Chem
; 291(47): 24628-24640, 2016 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27681596
4.
Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.
J Biol Chem
; 290(2): 889-903, 2015 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25425649
5.
Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
J Biol Chem
; 289(20): 13717-25, 2014 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24668804
6.
Structure activity relationships of human galactokinase inhibitors.
Bioorg Med Chem Lett
; 25(3): 721-7, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25553891
7.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922757
8.
Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation.
J Med Chem
; 67(3): 2019-2030, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38265364
9.
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Biochem Biophys Res Commun
; 438(2): 243-8, 2013 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23850693
10.
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Bioorg Med Chem Lett
; 23(12): 3654-61, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642479
11.
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.
Biochem J
; 448(1): 67-72, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22906073
12.
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.
Proc Natl Acad Sci U S A
; 107(11): 4878-83, 2010 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20194791
13.
SALL4B, not targeted by IMiD, is important for SALL4-mediated tumorigenesis.
bioRxiv
; 2023 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37461690
14.
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
bioRxiv
; 2023 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36909640
15.
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Cell Chem Biol
; 30(9): 1156-1168.e7, 2023 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37689063
16.
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J Biol Chem
; 286(36): 31232-40, 2011 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733839
17.
Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression.
Proc Natl Acad Sci U S A
; 106(9): 3585-90, 2009 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19208811
18.
Identification of a novel allosteric binding site in the CXCR2 chemokine receptor.
Mol Pharmacol
; 80(6): 1108-18, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21948388
19.
Identification of clinically used drugs that activate pregnane X receptors.
Drug Metab Dispos
; 39(1): 151-9, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20966043
20.
COPI complex is a regulator of lipid homeostasis.
PLoS Biol
; 6(11): e292, 2008 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19067489