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BACKGROUND: Chronic hip pain is one of the most common and difficult-to-treat causes of disability. Our study's primary aim was to investigate the effects of ultrasound and fluoroscopy-guided radiofrequency thermocoagulation of the femoral and obturator nerve articular branches on chronic hip pain, and the secondary aim was to determine its effects on hip function and quality of life. METHODS: Fifty-three patients with hip pain lasting more than three months were enrolled in the study. VPS scale and WOMAC, SF-12 questionnaires were applied to the patients before and in the first, third, and sixth months following the procedure. RESULTS: Of the patients, 60.4% were female, and 39.6% were male. Hip pain was caused by osteoarthritis in 77.1%, postoperative hip pain in 12.5%, malignancy in 8.3%, and avascular necrosis in 2.1%. The VPS scores were 8.9 ± 1.1 (mean±SD) in the baseline period, 2.4 ± 2.5 in the first postoperative week, 3.8 ± 2.5 in the first month, 5.1 ± 2.8 in the third month, and 5.8 ± 2.7 in the sixth month, with a significant decrease in VPS score (P < .001). One patient developed a motor deficit that improved spontaneously. CONCLUSIONS: We concluded that radiofrequency thermocoagulation application to the articular branches of the femoral and obturator nerves provides pain relief, hip function improvement, and better quality of life (better physical component scores but no improvement in mental component scores in SF-12) for up to 6 months in chronic hip pain.
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Dor Crônica , Eletrocoagulação , Nervo Femoral , Nervo Obturador , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Dor Crônica/cirurgia , Idoso , Eletrocoagulação/métodos , Adulto , Resultado do Tratamento , Qualidade de Vida , Articulação do Quadril/cirurgiaRESUMO
PURPOSE: Spinal surgeries are a very painful procedure. New regional techniques for postoperative pain management are being considered. The present study aimed to evaluate the hypothesis that the ultrasound-guided erector spinae plane (ESP) block would lead to lower opioid consumption compared to the thoracolumbar interfascial plane (TLIP) block after lumbar disk surgery. The study's primary objective was to compare postoperative total opioid consumption, and the secondary objective was to assess postoperative pain scores. METHODS: Sixty-eight patients who underwent elective lumbar disk surgery were randomly assigned to either the ESP block group or the TLIP block group. The current pain status of the patients in both the ESP and TLIP block groups was assessed using the Numerical Rating Scale (NRS) at specific time intervals (30 min, 1, 6, 12 and 24 h) during the postoperative period. The number of times patients administered a bolus dose of patient-controlled analgesia, (PCA) within the first 24 h was recorded. RESULTS: In the ESP group, the total opioid consumption in terms of morphine equivalents was found to be significantly lower (ESP group: 7.7 ± 7.0; TLIP group: 13.0 ± 10.1; p < 0.05). The NRS scores were similar between the groups at 30 min, 1, 6, and 12 h, but at 24 h, they were significantly lower in the ESP group. Moreover, the groups had no significant difference regarding observed side effects. CONCLUSION: This study demonstrated the analgesic efficacy of both techniques, revealing that the ESP block provides more effective analgesia in patients undergoing lumbar disk surgery.
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Dor Aguda , Bloqueio Nervoso , Humanos , Analgésicos Opioides/uso terapêutico , Anestésicos Locais , Bloqueio Nervoso/métodos , Dor Pós-Operatória/tratamento farmacológico , Dor Pós-Operatória/etiologia , Dor Pós-Operatória/prevenção & controle , Analgesia Controlada pelo Paciente , Período Pós-Operatório , Ultrassonografia de Intervenção/métodosRESUMO
BACKGROUND: Caudal epidural injections are easy, effective, and safe methods and are good options for patients with low back pain and radicular lower extremity pain. Although various complications related to the technique of the procedure or the drugs used in the procedure have been described, Posterior Reversible Encephalopathy Syndrome (PRES) has not yet been defined for this intervention. CASE: In this case report, we describe a case of PRES, which we supported with MRI findings in our patient who developed convulsions, changes in consciousness, and vision loss after being administered with caudal epidural steroid, and whose imaging findings regressed with the regression of clinical symptoms during the treatment process. CONCLUSION: Although PRES is rarely reported, it should be kept in mind that it is a complication that can develop after caudal epidural steroid injection.
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Anestesia Epidural , Dor Lombar , Síndrome da Leucoencefalopatia Posterior , Humanos , Injeções Epidurais/efeitos adversos , Dor Lombar/tratamento farmacológico , Imageamento por Ressonância Magnética , Síndrome da Leucoencefalopatia Posterior/induzido quimicamente , Síndrome da Leucoencefalopatia Posterior/diagnóstico por imagem , Esteroides/efeitos adversosRESUMO
This study aimed to perform genicular nerve RF neurotomy using two different imaging methods, fluoroscopy and ultrasound, and to compare the clinical effects and reliability of the two methods. Fifty patients with osteoarthritis were included in this study. Patients were randomly allocated into group 1 (fluoroscopy imaging) and group 2 (ultrasound imaging). Outcomes were measured using a pain scale (visual analog scale; VAS) and the Western Ontario and McMaster Universities (WOMAC) Index of Osteoarthritis. The application time in the ultrasound group (20.2 ± 6.4 min) was shorter than in the fluoroscopy group (25 ± 4.8 min) (p < 0.05). There was no difference in pain relief and functional status between the ultrasound and fluoroscopy groups. Decrease in VAS score and WOMAC total score in the first and third months was significant in both groups (p < 0.001). GNRFT under ultrasound guidance was easily applicable, safe and dynamic, and required no radiation to achieve the same benefit as the fluoroscopy-guided interventions.
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Denervação , Eletrocoagulação , Fluoroscopia , Joelho/inervação , Osteoartrite do Joelho/terapia , Ultrassonografia , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Articulação do Joelho , Masculino , Pessoa de Meia-Idade , Bloqueio Nervoso , Osteoartrite do Joelho/fisiopatologia , Manejo da Dor , Medição da Dor , Estudos Prospectivos , Ondas de Rádio , Reprodutibilidade dos Testes , Índice de Gravidade de Doença , Resultado do Tratamento , Escala Visual AnalógicaRESUMO
AIM: To evaluate the efficacy and safety of combined transforaminal anterior epidural steroid injection (TAESI) and dorsal root ganglion pulsed radiofrequency (DRG-PRF) therapy on the radicular neck pain. MATERIAL AND METHODS: The results of 84 patients with cervical radicular pain who underwent combined DRG-PRF and TAESI under fluoroscopy were evaluated retrospectively. Primer outcome is the pain measurements of the patients before and after the procedure at the 1 < sup > st < /sup > , 3 < sup > rd < /sup > , and 6 < sup > th < /sup > months were evaluated with the Verbal Pain Scale (VPS). Our secondary outcome was the evaluation of patient satisfaction in the 1 < sup > st < /sup > , 3 < sup > rd < /sup > , and 6 < sup > th < /sup > months after the interventional treatment, and it was considered significant if it was evaluated as ?good? above 50%. RESULTS: We found statistically significant decrease in the pain scores of the patients in the 1 < sup > st < /sup > , 3 < sup > rd < /sup > , and 6 < sup > th < /sup > months compared to the pre-intervention (VPS 0) (p < 0.001). After the procedure, the patients expressed their satisfaction level as 69.1% at the 1 < sup > st < /sup > month, 71.5% at the 3 < sup > rd < /sup > month, and 72.6% at the 6th month as ?very good/good?. While the operation was mostly performed at the C5-6 level on both sides, it was seen that 61.9% of the operations were applied from the right side and 38.1% from the left side. No adverse effects or fatal neurological complications were observed. CONCLUSION: Although the efficacy and complications of cervical TAESI and DRG-PRF treatment are controversial in the literature, we think that this combined treatment can provide effective pain palliation in experienced hands with appropriate patient selection, considering the risk / benefit ratio.
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Cervicalgia , Tratamento por Radiofrequência Pulsada , Humanos , Cervicalgia/terapia , Gânglios Espinais , Tratamento por Radiofrequência Pulsada/métodos , Estudos Retrospectivos , Resultado do Tratamento , EsteroidesRESUMO
Objectives: The objective of this study was to evaluate the clinical and radiological results of intra-articular injections performed with two different ultrasound-guided approaches in knee osteoarthritis. Patients and methods: The randomized controlled study was conducted on 80 knees of 40 patients (9 males, 31 females; mean age: 63.6±8.2 years; range, 46 to 78 years) with Grade 2-3 gonarthrosis that underwent ultrasound-guided intra-articular injections with suprapatellar (SP) or infrapatellar (IP) approaches between March 2020 and January 2021. After the injection, opaque material spread was fluoroscopically observed. Before the procedure and at the one and three months after the procedure, patients' Visual Analog Scale (VAS) scores for pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores for functional recovery were recorded. Results: In both techniques, one- and three-month VAS and WOMAC scores were found to be significantly lower (p<0.001 and p<0.001, respectively). Of the patients with positive opaque spread, 63.3% were in the IP technique group, and 36.7% were in the SP technique group (p=0.003). In 69.2% of those with radiologically positive opaque spread, the VAS score was significantly higher with >50% regression (p=0.04). In the IP technique, >50% regression rate of the VAS was 86.7% in patients with positive opaque spread, while VAS regression was significantly higher than those without opaque spread (p=0.02). Conclusion: Although the IP approach shows an early-positive opaque transition due to its proximity to the joint, both approach techniques are clinically effective under ultrasound guidance.
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Ischemic pain is the main symptom of a group of diseases that result in inadequate blood flow to the extremities and ischemia. In this symptomatology, two major diseases are distinguished: Critical vascular disease and Raynaud's phenomenon. Critical vascular disease background of atherosclerosis caused by diabetes mellitus or hypertension. Raynaud phenomenon is divided into primary and secondary form. The primary form is due to vasospasm and there is no underlying cause. Secondary form is associated with underlying connective tissue or rheumatic diseases, peripheral vascular diseases such as thromboangitis obliterans (Burger's disease). Clinical findings in Raynaud's disease are vasomotor changes with cold exposure such as bruising, coldness, painful paresthesias, and ulcers due to chronic ischemia. Clinic presentation in critical ischemic disease is intermittent claudication for earlier stage and resting pain, gangrene, necrosis, and trophic changes were added in advanced stages. The treatment of the Raynaud 's disease in early stage is medical and conservative. In case of advanced stage ischemic vascular disease, medical treatment resistant pain, insufficient response to endovascular treatment, and inoperabl cases, interventions such as sympathectomy and spinal cord stimulation (SCS) can be applicable. SCS reduces vascular resistance through vasodilator mediators and increases blood flow. SCS also suppresses sympathetic vasoconstriction, increases tissue vascularity, reduces tissue damage, provides ulcer healing and pain reduction. In this report, we demonstrated that persistent Raynaud's disease and advanced stage Burger's disease were successfully treated with SCS.
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Doença de Raynaud , Humanos , Doença de Raynaud/complicações , Doença de Raynaud/terapia , Doença de Raynaud/diagnóstico , Isquemia/complicações , Isquemia/tratamento farmacológico , Vasodilatadores , Dor/etiologia , Medula EspinalRESUMO
OBJECTIVES: The aim of this study was to investigate the effectiveness duration of the peripheral blocks applied with high concentration local anesthetic and steroid in trigeminal neuralgia. METHODS: The data of 48 patients (nine patients received medical treatment and 39 patients underwent interventional procedure for peripheral block and Gasser ganglion radiofrequency thermocoagulation [RFT]) were analyzed retrospectively. The medications used by patients, pre-operative and post-operative visual analog scale scores who underwent interventional procedures, and duration for effectiveness of the procedure were evaluated with 36 months follow-up. RESULTS: Forty-eight patients (32 females and 16 males) who were treated with primary and secondary etiologies were evaluated. Three patients V1, 12 patients V2, 25 patients V3, and eight patients V2+V3 trigeminal nerve branches described appropriate clinical symptoms. Only peripheral block was applied to 31 patients and Gasser ganglion RFT was applied to eight patients after peripheral block. In 24 patients who underwent peripheral block, pain severity reduction was ≥50%, mean effectiveness duration of peripheral block was 7.5 months. The eight patients undergoing Gasser ganglion RFT had ≥50% pain intensity reduction, mean effectiveness duration of Gasser ganglion RFT was 22.7 months (p=0.002). While one patient had hypoesthesia in the palate after RFT, no serious side effects were recorded. CONCLUSION: The duration of pain control for peripheral branch blocks in trigeminal neuralgia is not as long as RFT, but it is a relatively less invasive and less complicated interventional technique with good efficacy duration due to neurotoxicity of the used high concentrated local anesthetic.
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Neuralgia do Trigêmeo , Masculino , Feminino , Humanos , Neuralgia do Trigêmeo/tratamento farmacológico , Neuralgia do Trigêmeo/cirurgia , Anestésicos Locais/uso terapêutico , Estudos Retrospectivos , Resultado do Tratamento , Eletrocoagulação/métodos , Esteroides/uso terapêuticoRESUMO
AIM: To evaluate the effect of various temperatures and durations of radiofrequency thermocoagulation (RFT) for the treatment of low back pain that is caused by facet joints. MATERIAL AND METHODS: This is a randomized controlled, double-blind study. Patients diagnosed with facet syndrome were randomly divided into three groups. RFT was applied to the medial branches, which received senses from the facet joint 90°C 50 seconds in 31 patients, 85°C 60 seconds in 32 patients, 70°C 90 seconds in 33 patients at constant current and impedance values. Numeric Rating Scale (NRS) scores before and after the treatment (1 and 6 months), the need for additional analgesics after treatment, and opioid dose changes were recorded. RESULTS: The demographic data of the groups were similar. NRS scores in all three groups were significantly lower at 1 and 6 months (p < 0.001, p < 0.001, p < 0.001, respectively). At the first and sixth months, there was no significant difference between the groups in patients who experienced a 50% reduction in pain intensity (p=0.1, p=0.7, respectively). Patients who had back surgery had a significantly lower rate of pain regression (p=0.001). CONCLUSION: In patients with lumbar facet syndrome, RFT application in every 3 degrees and seconds is effective because it generates equal energy, and there was no significant difference in pain relief between the groups.
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Dor Lombar , Articulação Zigapofisária , Método Duplo-Cego , Eletrocoagulação , Humanos , Dor Lombar/cirurgia , Vértebras Lombares/cirurgia , Temperatura , Resultado do Tratamento , Articulação Zigapofisária/cirurgiaRESUMO
In addition to medical approaches, laser revascularization, transmyocardial laser revascularization, angiogenesis, growth factor gene therapy, thoracic epidural anesthesia, and spinal cord simulation are used to treat chronic refractory angina pectoris. A unilateral left stellate ganglion block is another alternative. It may particularly be considered as a palliative intervention in patients with a short life span. Described here is the case of a 66-year-old male patient for whom a unilateral left stellate ganglion blockade was used to treat chronic refractory angina pectoris.
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Bloqueio Nervoso Autônomo , Terapia a Laser , Idoso , Angina Pectoris/terapia , Humanos , Masculino , Revascularização Miocárdica , Gânglio EstreladoRESUMO
OBJECTIVES: Demonstrate of accidental intravascular injection during lumbar transforaminal anterior epidural steroid injection (TAESI) performed with three-dimensional imaging angiography (3DIA) and fluoroscopy. METHODS: We assessed 20 (9 males and 11 females) patients (with a total of 40 levels) whose images were received with simultaneously 3DIA and fluoroscopy-guided TAESI between January 2016 and September 2016 as retrospective. Injections were carried out in the lumbar fourth intervertebral space bilaterally and performed in the same way all of the cases. RESULTS: The mean age and body mass index of the patients were 47.9±2.72 years and 26.95±1.21, respectively. There were 10 patients with disc herniation, seven patients with spinal stenosis, and three patients with failed back surgery syndrome. In 3D imaging, vascular escape was detected in the 7 levels (17.5%) which were thought to be no escape in the fluoroscopy imaging. CONCLUSION: In chronic lumbar radiculopathy patients, intravascular escapes may occur during the fluoroscopic TAESI procedure. To avoid intravascular injections during TAESI procedure, it may be appropriate to use different imaging methods that can give more detailed results such as 3D angiography.
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Radiculopatia , Feminino , Fluoroscopia , Humanos , Injeções Epidurais , Vértebras Lombares/diagnóstico por imagem , Masculino , Radiculopatia/tratamento farmacológico , Estudos Retrospectivos , Esteroides/uso terapêuticoRESUMO
OBJECTIVES: The aim of this retrospective study was to evaluate the efficacy of transforaminal anterior epidural steroid and local anesthetic injections (TAESE) and the effects on quality of life in patients with low back pain. METHODS: The study patients (n=191) were divided into 3 groups: disc herniation (DH), failed back surgery (FBS), and spinal stenosis (SS). A visual analog scale (VAS) and verbal pain scale (VPS) were used to assess patient pain. Scores were measured before treatment (VAS 0), in the first month of application (VAS 1), 3 months (VAS 3), and 6 months (VAS 6). Patient quality of life was examined using the 36-Item Short Form Health Survey (SF-36). RESULTS: In all 3 groups, there was a statistically significant reduction in pain compared with the VAS 0 score at 1, 3, and 6 months (p<0.001). The reduction in VAS/VPS was greatest in the DH group, followed by the FBS and SS groups, respectively. All of the parameters of the SF-36 measurement were lower in the SS patients compared with the DH patients. The quality of life score was lowest in the SS patients, though the physical health and social functioning scores were lowest in the FBS group. CONCLUSION: TAESE is effective and can be safely performed in patients who have low back pain due to DH, FBS, or SS. The quality of life result was less successful in SS patients, particularly in the parameter of physical role limitations.
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Deslocamento do Disco Intervertebral/tratamento farmacológico , Dor Lombar/tratamento farmacológico , Qualidade de Vida , Esteroides/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Síndrome Pós-Laminectomia/tratamento farmacológico , Síndrome Pós-Laminectomia/psicologia , Feminino , Humanos , Injeções Epidurais , Deslocamento do Disco Intervertebral/psicologia , Dor Lombar/psicologia , Vértebras Lombares , Masculino , Pessoa de Meia-Idade , Manejo da Dor , Estudos Retrospectivos , Estenose Espinal/tratamento farmacológico , Estenose Espinal/psicologia , Esteroides/administração & dosagem , Resultado do Tratamento , Adulto JovemRESUMO
Treatment of burning mouth syndrome (BMS) is challenging because there is no consensus regarding pharmalogical or nonpharmalogical therapies. The use of anticonvulsants is controversial. We present nine patients BMS who respond to pregabalin. They were diagnosed secondary BMS except two. Etiologic regulations were made firstly in patients with secondary BMS but symptoms did not decrease. We preferred pregabalin in all patients and got good results. Furthermore the addition of pregabalin to the treatment of two patients who did not respond adequately to duloxetine provided good results. We are only aware that pregabalin may reduce symptoms as a result of case reports. We believe that the diagnosis of pathologic etiology with appropriate diagnostic tests will result in better outcomes in treatment.
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BACKGROUND AND OBJECTIVES: Fluctuations of female sex hormones during menstrual cycle influence pain perception. Endogenous pain inhibition is impaired in follicular phase of menstrual cycle. We tested the primary hypothesis that the women having surgery during their follicular phase have more acute pain and require higher opioids than those in the luteal phase, and secondarily we tested that women who have surgery during their follicular phase have more incisional pain at 3 month postoperatively. METHODS: 127 adult females having laparoscopic cholecystectomy were randomized to have surgery during the luteal or follicular phase of their menstrual cycle. Standardized anesthesia and pain management regimen was given to all patients. Pain and analgesic consumption were evaluated in post-anesthesia care unit and every 4h in the first 24h. Adverse effects were questioned every 4h. Time to oral intake and ambulation were recorded. Post-surgical pain, hospital anxiety, depression scale, SF-12 questionnaire were evaluated at 1 and 3 month visits. RESULTS: There was no difference in acute pain scores and analgesic consumption through the 24h period, Visual Analog Scale at 24h was 1.5±1.5cm for follicular group 1.4±1.7cm for luteal group (p=0.57). Persistent postoperative pain was significantly more common one and at three month, with an incidence was 33% and 32% in the patients at follicular phase versus 16% and 12% at luteal phase, respectively. The Visual Analog Scale at one and at three month was 1.6±0.7cm and 1.8±0.8cm for follicular group and 2.7±1.3cm and 2.9±1.7cm in the luteal group (p=0.02), respectively. There were no significant differences between the groups with respect to anxiety and depression, SF-12 scores at either time. Nausea was more common in follicular-phase group (p=0.01) and oral feeding time was shorter in follicular phase (5.9±0.9h) than in luteal phase (6.8±1.9h, p=0.02). CONCLUSIONS: Although persistent postoperative pain was significantly more common one and three months after surgery the magnitude of the pain was low. Our results do not support scheduling operations to target particular phases of the menstrual cycle.
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Our aim was to investigate the effects of patient-controlled sedo/analgesia with fentanyl or remifentanil during cataract surgery with phacoemulsification method under topical anaesthesia. The ethical committee has approved the prospective, randomized, double-blind study. ASA I-III, 120 patients underwent cataract surgery were randomly allocated to 3 groups. Fentanyl was administered in 0.7 microg/kg loading, 10 microg bolus dose with 5 minutes lockout time, remifentanil was administered 0.3 microg/kg loading, 20 microg bolus dose with 3 minutes lockout time by patient controlled analgesia (PCA) equipment. In the control group, saline solution was given without any analgesic drug. Cardiorespiratory system findings, verbal pain scale and sedation scores were recorded preoperatively and intraoperatively at the 5th, 10th, 15th, 20th and 30th minutes. Discomfort during surgery, pressing the PCA button, and complications were recorded. The verbal pain scale scores was significantly lower in the drug groups than the those in control group at the 15th minute. The sedation scores was significantly higher in the remifentanil group at the 5th minute (p=0.019) and in the fentanyl group at the 10th minute (p=0.007) than those in the control group. The number of patients pressing the PCA button was much higher in the control group than the drug groups (p<0.05). Patient comfort and surgeon satisfaction were higher in the drug groups (p<0.05). Intravenous-PCA sedo/analgesia addition to topical anaesthesia provides an advantage in sedo/analgesia, patient comfort, and surgeon satisfaction. PCA is a convenient and safe method, especially at the beginning of the operation when anxiety is intense, and during healon/lens implantation.
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Analgésicos Opioides/administração & dosagem , Fentanila/administração & dosagem , Dor Pós-Operatória/prevenção & controle , Piperidinas/administração & dosagem , Idoso , Analgesia Controlada pelo Paciente , Extração de Catarata , Método Duplo-Cego , Feminino , Humanos , Infusões Intravenosas , Masculino , Medição da Dor , Dor Pós-Operatória/fisiopatologia , Estudos Prospectivos , Remifentanil , Resultado do TratamentoRESUMO
AIM: To investigate the impact of statin use on response to fluoroscopy-assisted transforaminal anterior epidural steroid injection (TAESI). METHODS: Patients undergoing TAESI for low back pain were recruited and stratified according to statin use. Pain was evaluated with a visual analogue scale (VAS) before and at 1, 3, and 6 months after TAESI. Health-related quality-of-life was evaluated using the Short Form 36 (SF-36) questionnaire 6 months after TAESI. RESULTS: There were no significant differences in VAS scores after TAESI between statin users (n = 40) and statin nonusers (n = 253). The SF-36 subgroup: role limitations due to emotional problems score was significantly lower in statin users than statin nonusers. There were no significant between-group differences in any other SF-36 parameter. CONCLUSION: Statin use had no effect on pain scores after TAESI.
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Analgésicos/uso terapêutico , Bupivacaína/uso terapêutico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Dor Lombar/tratamento farmacológico , Radiculopatia/tratamento farmacológico , Triancinolona Acetonida/uso terapêutico , Adulto , Idoso , Combinação de Medicamentos , Feminino , Fluoroscopia , Humanos , Injeções Epidurais , Dor Lombar/fisiopatologia , Vértebras Lombares/efeitos dos fármacos , Vértebras Lombares/fisiopatologia , Masculino , Pessoa de Meia-Idade , Manejo da Dor/métodos , Medição da Dor/métodos , Estudos Prospectivos , Radiculopatia/fisiopatologia , Resultado do TratamentoRESUMO
Transdermal nitroglycerine can improve analgesic effects when used with other analgesics. The aim of the study was to investigate the additive effects of nitroglycerine combined with lornoxicam for acute pain in rats. Thirty-nine Wistar male rats were divided into five groups; Group SF (n=8, saline), Group L-1 (n=8, lornoxicam 1.3 mg/kg), Group L-2 (n=8, lornoxicam 2.6 mg/kg), Group LNO (n=8, nitroglycerine and lornoxicam, 1 mg/kg+1.3 mg/kg), and Group LNO-2 (n=8, nitroglycerine and lornoxicam, 1 mg/ kg+2.6 mg/kg). Tail flick and hot plate tests were measured in all groups before the intraperitoneal injections of drug and 30, 60 and 90 minutes after the injections. Cut-off time was 20 s and 60 s in tail-flick and hot-plate tests. Although there were significant differences between the groups according to hot-plate test at the 30th, 60th and 90th minutes (p<0.05), there was no difference between the groups with tail flick test. The most increasing of latency response in hot-plate assays was seen in Group LNO-1 compared to other groups at the 30th minute (p<0.05). The latency response increased significantly in Group L-1, L-2, LNO-1 and LNO-2 compared with saline group at the 60th and 90th minutes (p<0.05). There were significant differences in latency responses in Group L-1 and Group LNO-1 compared to Group L-2 and Group LNO-2 at the 60th and 90th minutes. In conclusion, 1.3 mg/kg dose of lornoksicam with the use of nitrogliserine provided early and efficient analgesia, but the increasing dose of lornoksicam did not maintain better analgesia.
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Analgésicos/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Nitroglicerina/uso terapêutico , Dor/tratamento farmacológico , Piroxicam/análogos & derivados , Doença Aguda , Analgésicos/administração & dosagem , Animais , Anti-Inflamatórios não Esteroides/administração & dosagem , Quimioterapia Combinada , Temperatura Alta , Injeções Intraperitoneais , Masculino , Nitroglicerina/administração & dosagem , Dor/patologia , Medição da Dor , Piroxicam/administração & dosagem , Piroxicam/uso terapêutico , Ratos , Ratos WistarRESUMO
OBJECTIVES: Transforaminal anterior steroid injections are frequently used for low back pain. In the current study, It was aimed to investigate the effects of transforaminal anterior epidural steroid injection (TAESI) in patients with low back pain in regards to quality of life and sleep, and neuropathic pain. METHODS: Ethics committee approval and patient consent were obtained. Patients with low back pain scheduled to receive transforaminal epidural steroid injections between October 2011 and October 2012 were included into the study. Pittsburgh Sleep Quality Index (PSQI), Short form 12 (SF 12), DN4 tests and Visual Analog Scale Score (VAS) were measured prior to procedure and three months later. All the tests were compared with baseline evaluations prior to injections. RESULTS: One hundred and two (female/male: 52/50) patients with a mean age of 53.3 ± 1.4 were included. Primary diagnoses were lumbar disc herniation in eighty-seven patients, spinal stenosis in seven and failed back surgery syndrome in eight patients. Statistically significant improvement was seen in the total VAS, DN4 and PSQI scores (p=0.0001) of the patients at the third month follow-up. Sleep duration (p=0.0001), habitual sleep efficiency (p=0.0001), subjective sleep quality (p=0.003), sleep latency (p=0.014), sleep disturbances (p<0.001), sleep medication use (p=0.003), and day time dysfunction (p=0.015) showed a significant decrease in sub-components. There was no significant difference in SF 12 quality of life. CONCLUSION: It was determined in the study that transforaminal epidural steroid injection provided a substantial improvement in patients' pain and neuropathic pain and quality of sleep, but had no effect on the quality of life.
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Dor Lombar/tratamento farmacológico , Vértebras Lombares , Esteroides/administração & dosagem , Feminino , Humanos , Injeções Epidurais , Masculino , Pessoa de Meia-Idade , Medição da Dor , Qualidade de Vida , Sono , Resultado do TratamentoRESUMO
PURPOSE: To investigate the effects of intravenous (IV) patient-controlled sedation/analgesia with fentanyl during phacoemulsification surgery under topical anesthesia. SETTING: Adnan Menderes University Medical School, Departments of Ophthalmology and Anesthesiology and Reanimation, Aydin, Turkey. METHODS: In this double-blind randomized study, 68 patients were randomly allocated to 2 groups. In the fentanyl group comprising 34 patients, fentanyl was administered by patient-controlled analgesia (PCA) equipment in 5 microg bolus doses with a lockout period of 5 minutes after an IV loading dose of 0.7 microg/kg in 2 mL balanced salt solution. In the control group comprising 34 patients, a balanced salt solution was given without an analgesic drug by PCA equipment. Verbal pain scale (VPS) and sedation scores were recorded preoperatively and 5, 10, 15, 20, and 30 minutes after the start of surgery. Patient comfort and surgeon satisfaction were assessed postoperatively. RESULTS: The sedation score was higher in the fentanyl group than in the control group at 5 and 10 minutes (P =.006 and P =.012, respectively). The VPS scores were higher in the control group than in the fentanyl group at 15 and 20 minutes (P =.02 and P =.016, respectively). Patients pressed the button for additional analgesia 2.6 times +/- 3.9 (SD) in the control group and 0.9 +/- 1.6 times in the fentanyl group (P =.025). Patient and surgeon satisfaction were higher in the fentanyl group than the control group (P =.023 and P =.018, respectively). CONCLUSIONS: The results of this study suggest that IV PCA with fentanyl has supplemental effects on analgesia and sedation during cataract surgery under topical anesthesia and increases patient comfort and surgeon satisfaction.
Assuntos
Analgesia Controlada pelo Paciente , Analgésicos Opioides/administração & dosagem , Anestesia Local , Extração de Catarata , Fentanila/administração & dosagem , Facoemulsificação , Adulto , Idoso , Idoso de 80 Anos ou mais , Analgésicos Opioides/uso terapêutico , Grupos Controle , Método Duplo-Cego , Feminino , Fentanila/uso terapêutico , Humanos , Injeções Intravenosas , Masculino , Pessoa de Meia-Idade , Satisfação do Paciente , Estudos Prospectivos , Fatores de TempoRESUMO
Stellate ganglion block (SGB) is one of the most often used sympathetic blockade procedure. Despite performed by experienced physicians some complications may occur. The right brachial plexus injury was diagnosed in the patient who admitted to orthopedia clinic, with weakness in the right arm, and pain after motor vehicle accident. There was no response to medical treatment of fortyfour-years-old female patient and there was loosing of sensation from dis the right elbow joint to fingers on the radial and median nerve tracing. In the electromyelography; C5-T1 root avulsion, and MRI; Patient was evaluated as CPRS I (Complex regional pain syndrome) phase 1. In spite of medical treatment, SGB was performed. Respiratory arrest occurred 4-5 minutes after injection. Patient was breated with mechanical ventilator during 2 hours, and discharged 24 hours later with normal vital functions. One year later, the patient admitted the algology polyclinic with strong pain in the same area. Stellate ganglion Radyofreguency (RF) was planned. The first RF cannula was placed under fluoroscopy. Cerebrospinal fluid was seen in the second canula, and canula was withdrawn. Third cannula was placed in another region, and conventional RF was performed through two canuls. For anatomical structure defect, we planned cervical MR myelography. In the cervical MR myelography, traumatic pseudomeningocele was observed at the level of C6-T1 on the brachial plexus. Intraspinal block was thought to develop during blockade of stellate ganglion due to this.