Detalhe da pesquisa
1.
X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists.
Angew Chem Int Ed Engl
; 59(38): 16536-16543, 2020 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32542862
2.
Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke.
Ann Neurol
; 84(2): 260-273, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30014516
3.
Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.
Molecules
; 22(3)2017 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28264466
4.
Integrated Ugi-based assembly of functionally, skeletally, and stereochemically diverse 1,4-benzodiazepin-2-ones.
J Org Chem
; 80(3): 1533-49, 2015 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25560990
5.
Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction.
Chembiochem
; 15(10): 1471-80, 2014 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24943831
6.
Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents.
Biomed Pharmacother
; 173: 116345, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38442670
7.
Multicomponent assembly of diverse pyrazin-2(1H)-one chemotypes.
J Org Chem
; 78(9): 4402-9, 2013 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23551216
8.
Copper-catalyzed Huisgen 1,3-dipolar cycloaddition under oxidative conditions: polymer-assisted assembly of 4-acyl-1-substituted-1,2,3-triazoles.
J Org Chem
; 78(13): 6540-9, 2013 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23738944
9.
Pharmacological insights emerging from the characterization of a large collection of synthetic cannabinoid receptor agonists designer drugs.
Biomed Pharmacother
; 164: 114934, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37236027
10.
Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists.
J Med Chem
; 66(1): 890-912, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36517209
11.
A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models.
J Immunother Cancer
; 10(5)2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35580926
12.
Exploring Non-orthosteric Interactions with a Series of Potent and Selective A3 Antagonists.
ACS Med Chem Lett
; 13(2): 243-249, 2022 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178181
13.
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists.
J Med Chem
; 65(3): 2091-2106, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35068155
14.
Potent and Subtype-Selective Dopamine D2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach.
J Med Chem
; 64(12): 8710-8726, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110150
15.
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.
J Med Chem
; 64(1): 458-480, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33372800
16.
Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists.
J Med Chem
; 63(14): 7721-7739, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32573250
17.
Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition.
J Med Chem
; 62(20): 9315-9330, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31557025
18.
Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists.
J Med Chem
; 60(17): 7502-7511, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28792759
19.
Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.
J Cheminform
; 9(1): 67, 2017 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29290010
20.
Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates.
J Med Chem
; 60(8): 3372-3382, 2017 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368607