RESUMO
Cytogenetic findings on seven mixed salivary gland tumors are reported herein. The involvement of chromosome #8 in clonal chromosome aberrations in five of the seven tumors was particularly noteworthy. Four tumors had translocations involving chromosome #8 and one or two other chromosomes (#3, #7, #9, #13). The fifth showed a deletion of parts of the long arm of chromosome #8. In an attempt to define the critical segment on chromosome #8, we have identified the part between 8q11 and 8q13 as the critical region involved in all rearrangements. Thus far, our results confirm the results of the Swedish group, though the percentage of cases having #8 abnormalities is somewhat higher in our small series. The relationship between the two groups of cases, those with and those without chromosome abnormalities, will be discussed.
Assuntos
Adenoma Pleomorfo/genética , Aberrações Cromossômicas , Cromossomos Humanos Par 8 , Neoplasias Parotídeas/genética , Adolescente , Adulto , Idoso , Bandeamento Cromossômico , Feminino , Humanos , Cariotipagem , Masculino , Pessoa de Meia-Idade , Translocação GenéticaRESUMO
Cytogenetic findings on the recurrence of a pleomorphic adenoma of the parotid gland are herein reported. The tumor showed an abnormal chromosome #8, which was very similar to a marker chromosome recently described as the sole abnormality in an endometrial adenocarcinoma.
Assuntos
Adenocarcinoma/genética , Adenoma Pleomorfo/genética , Neoplasias Parotídeas/genética , Translocação Genética , Neoplasias Uterinas/genética , Bandeamento Cromossômico , Cromossomos Humanos Par 3 , Cromossomos Humanos Par 8 , Feminino , Marcadores Genéticos , Humanos , Cariotipagem , Masculino , Pessoa de Meia-IdadeRESUMO
Nine pleomorphic adenomas of the human parotid gland were investigated. Within this series the group of cases having clonal aberrations of chromosome Nr 8 predominates. The occurrence of cases with trisomy-8 and cases with structural rearrangements involving a breakpoint in 8q11-8q13 allows a further subdivision of this group of tumors. Our special interest in this paper is devoted to the latter group. The hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis, leading to activation of a so far unknown oncogene located most likely at 8q12. The translocations to different recipient chromosomes may serve as sign posts to transcriptionally active chromosomal domains in the salivary gland.