Detalhe da pesquisa
1.
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response.
EMBO J
; 40(14): e100715, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34152608
2.
Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia.
J Neuroinflammation
; 21(1): 58, 2024 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38409076
3.
Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist.
Bioorg Med Chem Lett
; 100: 129629, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38295907
4.
VCP/p97 regulates Beclin-1-dependent autophagy initiation.
Nat Chem Biol
; 17(4): 448-455, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33510452
5.
Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme.
Proc Natl Acad Sci U S A
; 117(1): 677-688, 2020 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31871190
6.
Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators.
Bioorg Med Chem Lett
; 61: 128607, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35123006
7.
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Bioorg Med Chem Lett
; 29(1): 83-88, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463802
8.
Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.
Bioorg Med Chem Lett
; 29(15): 1962-1967, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31153805
9.
N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.
J Biol Chem
; 292(52): 21253-21263, 2017 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29092909
10.
A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.
Nat Chem Biol
; 12(6): 444-51, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27110679
11.
Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening.
Bioorg Med Chem Lett
; 28(19): 3231-3235, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30170942
12.
Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment.
ACS Med Chem Lett
; 15(5): 646-652, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38746889
13.
Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner.
Nat Commun
; 15(1): 2358, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38509128
14.
Discovery of CVN417, a Novel Brain-Penetrant α6-Containing Nicotinic Receptor Antagonist for the Modulation of Motor Dysfunction.
J Med Chem
; 66(17): 11718-11731, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37651656
15.
Discovery and Characterization of Novel CNS-Penetrant GPR55 Agonists.
J Med Chem
; 66(18): 12858-12876, 2023 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37708305
16.
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.
Cell Rep Med
; 4(3): 100957, 2023 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889319
17.
Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist.
ACS Med Chem Lett
; 14(4): 442-449, 2023 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37077399
18.
Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome.
Neuropharmacology
; 224: 109330, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36375694
19.
Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett
; 22(6): 2262-5, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22365755
20.
Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P1 agonists with in vivo lymphocyte-depleting activity.
Bioorg Med Chem Lett
; 22(1): 628-33, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22100314