Detalhe da pesquisa
1.
Lysophosphatidic acid receptor 1 antagonist (EPGN2154) causes regression of NASH in preclinical NASH models.
Hepatol Commun
; 7(12)2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37994050
2.
Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4.
FASEB J
; 24(12): 4701-10, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20686109
3.
Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2).
Int Immunol
; 21(6): 621-32, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19346259
4.
A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
Int Immunol
; 21(1): 81-93, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19066314
5.
Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms.
Int Immunol
; 21(1): 1-17, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19066315
6.
Targeting MAP3K19 prevents human lung myofibroblast activation both in vitro and in a humanized SCID model of idiopathic pulmonary fibrosis.
Sci Rep
; 9(1): 19796, 2019 12 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31875033
7.
Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4.
Eur J Pharmacol
; 559(2-3): 202-9, 2007 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234179
8.
Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor.
Clin Cancer Res
; 11(5): 1974-82, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15756023
9.
MAP3K19 Is a Novel Regulator of TGF-ß Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis.
PLoS One
; 11(5): e0154874, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27144281
10.
MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction.
PLoS One
; 11(12): e0167169, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27935962
11.
A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.
Br J Pharmacol
; 145(2): 178-92, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15753951
12.
CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.
Eur J Pharmacol
; 524(1-3): 30-7, 2005 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16256979
13.
A versatile high-throughput screen for inhibitors of lipid kinase activity: development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma.
J Biomol Screen
; 7(5): 441-50, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14599360
14.
CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.
Am J Physiol Lung Cell Mol Physiol
; 295(5): L767-79, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757520
15.
Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.
J Nat Prod
; 70(2): 246-52, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17249727
16.
PAR-2 deficient CD4+ T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice.
Allergol Int
; 55(3): 271-8, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17075267
17.
Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview.
Expert Opin Investig Drugs
; 14(7): 769-73, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16022566
18.
Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo.
J Pharmacol Exp Ther
; 307(3): 1072-8, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14551291
19.
Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan.
J Pharmacol Exp Ther
; 310(1): 272-80, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-14996947
20.
Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.
Int Immunol
; 16(5): 685-95, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15096484