RESUMO
Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.
Assuntos
Antituberculosos/uso terapêutico , Sistemas de Liberação de Medicamentos , Estômago/efeitos dos fármacos , Tuberculose/tratamento farmacológico , Animais , Antibacterianos/uso terapêutico , Antituberculosos/farmacologia , Preparações de Ação Retardada , Relação Dose-Resposta a Droga , Doxiciclina/uso terapêutico , Sistemas de Liberação de Medicamentos/economia , Liberação Controlada de Fármacos , Humanos , SuínosRESUMO
Background: Alteration in the pattern of serum lipid profile has been associated with a variety of cancers and precancerousconditions. Low levels of serum lipid serve as a prognostic marker in the early detection of oral precancerous and cancerousconditions because lipid plays an important role in new membrane biogenesis and maintains cell integrity.Aim: The aim of our study is to evaluate the alteration in serum lipid profile in oral squamous cell carcinoma (OSCC) andcompared it with control group.Materials and Methods: A total of 80 subjects were selected from the Department of Oral Pathology and Microbiology,RUHS College of Dental Sciences, Jaipur (GDC-Jaipur). Among 80 subjects, 40 individuals were diagnosed with squamouscell carcinoma and other 40 individuals were taken in healthy control group selected randomly from other departments. Thetotal parameters assessed include total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoproteincholesterol (LDLC), very LDLC, and triglycerides (TGLs). Statistical analysis was carried out by Chi-square and one-wayANOVA test to evaluate parameters.Results: There was a significant decrease in TC, HDLC, and TGL in the oral cancer group as compared with the control group.Conclusions: There was an inverse relationship between serum lipid profile and OSCC. The lower serum lipid status may beconsidered a useful prognostic biochemical indicator for initial changes occurring in the neoplastic proliferating cell.