Detalhe da pesquisa
1.
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
Bioorg Med Chem Lett
; 60: 128549, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041943
2.
α-Methylene-ß-Lactone Scaffold for Developing Chemical Probes at the Two Ends of the Selectivity Spectrum.
Chembiochem
; 22(3): 505-515, 2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32964640
3.
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
Cell Mol Neurobiol
; 41(4): 669-685, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32424773
4.
Scaling Proteome-Wide Reactions of Activity-Based Probes.
Anal Chem
; 89(12): 6295-6299, 2017 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28570047
5.
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
Bioorg Med Chem Lett
; 72: 128856, 2022 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35728998
6.
Development of structural marker peptides for cystic fibrosis transmembrane conductance regulator in cell plasma membrane by reversed-footprinting mass spectrometry.
Anal Chem
; 87(17): 8603-7, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26236917
7.
Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane.
J Proteome Res
; 13(11): 4676-85, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25227318
8.
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 67(10): 8122-8140, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712838
9.
Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
ACS Chem Neurosci
; 14(6): 1080-1094, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812145
10.
Free lipid A isolated from Porphyromonas gingivalis lipopolysaccharide is contaminated with phosphorylated dihydroceramide lipids: recovery in diseased dental samples.
Infect Immun
; 80(2): 860-74, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22144487
11.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734694
12.
Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice.
Front Neurol
; 12: 624051, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34262517
13.
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells.
Clin Transl Immunology
; 10(6): e1295, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141433
14.
Ultrathroughput multiple reaction monitoring mass spectrometry.
Anal Chem
; 82(3): 794-7, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20063866
15.
Site-preferential dissociation of peptides with active chemical modification for improving fragment ion detection.
Anal Chem
; 82(1): 23-7, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19904916
16.
Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.
PLoS One
; 15(4): e0228771, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32255788
17.
Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.
Elife
; 92020 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579115
18.
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
J Med Chem
; 63(21): 12526-12541, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696648
19.
Passive and active fragment ion mass defect labeling: distinct proteomics potential of iodine-based reagents.
Anal Chem
; 81(15): 6438-48, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19572545
20.
Cyclophosphoramidate ion as mass defect marker for efficient detection of protein serine phosphorylation.
Anal Chem
; 80(19): 7614-23, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18781815