Pesquisa | Biblioteca Virtual em Saúde

1.

Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells.

Watson, Joseph L; Krüger, Lara K; Ben-Sasson, Ariel J; Bittleston, Alice; Shahbazi, Marta N; Planelles-Herrero, Vicente Jose; Chambers, Joseph E; Manton, James D; Baker, David; Derivery, Emmanuel.

Cell ; 186(21): 4710-4727.e35, 2023 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-37774705

2.

Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle.

Wang, Yaxi; Gallagher, Larry A; Andrade, Pia A; Liu, Andi; Humphreys, Ian R; Turkarslan, Serdar; Cutler, Kevin J; Arrieta-Ortiz, Mario L; Li, Yaqiao; Radey, Matthew C; McLean, Jeffrey S; Cong, Qian; Baker, David; Baliga, Nitin S; Peterson, S Brook; Mougous, Joseph D.

Cell ; 186(22): 4803-4817.e13, 2023 10 26.

Artigo em Inglês | MEDLINE | ID: mdl-37683634

3.

Accurate de novo design of membrane-traversing macrocycles.

Bhardwaj, Gaurav; O'Connor, Jacob; Rettie, Stephen; Huang, Yen-Hua; Ramelot, Theresa A; Mulligan, Vikram Khipple; Alpkilic, Gizem Gokce; Palmer, Jonathan; Bera, Asim K; Bick, Matthew J; Di Piazza, Maddalena; Li, Xinting; Hosseinzadeh, Parisa; Craven, Timothy W; Tejero, Roberto; Lauko, Anna; Choi, Ryan; Glynn, Calina; Dong, Linlin; Griffin, Robert; van Voorhis, Wesley C; Rodriguez, Jose; Stewart, Lance; Montelione, Gaetano T; Craik, David; Baker, David.

Cell ; 185(19): 3520-3532.e26, 2022 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-36041435

4.

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.

Marcandalli, Jessica; Fiala, Brooke; Ols, Sebastian; Perotti, Michela; de van der Schueren, Willem; Snijder, Joost; Hodge, Edgar; Benhaim, Mark; Ravichandran, Rashmi; Carter, Lauren; Sheffler, Will; Brunner, Livia; Lawrenz, Maria; Dubois, Patrice; Lanzavecchia, Antonio; Sallusto, Federica; Lee, Kelly K; Veesler, David; Correnti, Colin E; Stewart, Lance J; Baker, David; Loré, Karin; Perez, Laurent; King, Neil P.

Cell ; 176(6): 1420-1431.e17, 2019 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-30849373

5.

Structure of the type VI secretion system contractile sheath.

Kudryashev, Mikhail; Wang, Ray Yu-Ruei; Brackmann, Maximilian; Scherer, Sebastian; Maier, Timm; Baker, David; DiMaio, Frank; Stahlberg, Henning; Egelman, Edward H; Basler, Marek.

Cell ; 160(5): 952-962, 2015 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-25723169

6.

De novo design of high-affinity binders of bioactive helical peptides.

Vázquez Torres, Susana; Leung, Philip J Y; Venkatesh, Preetham; Lutz, Isaac D; Hink, Fabian; Huynh, Huu-Hien; Becker, Jessica; Yeh, Andy Hsien-Wei; Juergens, David; Bennett, Nathaniel R; Hoofnagle, Andrew N; Huang, Eric; MacCoss, Michael J; Expòsit, Marc; Lee, Gyu Rie; Bera, Asim K; Kang, Alex; De La Cruz, Joshmyn; Levine, Paul M; Li, Xinting; Lamb, Mila; Gerben, Stacey R; Murray, Analisa; Heine, Piper; Korkmaz, Elif Nihal; Nivala, Jeff; Stewart, Lance; Watson, Joseph L; Rogers, Joseph M; Baker, David.

Nature ; 626(7998): 435-442, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38109936

7.

Blueprinting extendable nanomaterials with standardized protein blocks.

Huddy, Timothy F; Hsia, Yang; Kibler, Ryan D; Xu, Jinwei; Bethel, Neville; Nagarajan, Deepesh; Redler, Rachel; Leung, Philip J Y; Weidle, Connor; Courbet, Alexis; Yang, Erin C; Bera, Asim K; Coudray, Nicolas; Calise, S John; Davila-Hernandez, Fatima A; Han, Hannah L; Carr, Kenneth D; Li, Zhe; McHugh, Ryan; Reggiano, Gabriella; Kang, Alex; Sankaran, Banumathi; Dickinson, Miles S; Coventry, Brian; Brunette, T J; Liu, Yulai; Dauparas, Justas; Borst, Andrew J; Ekiert, Damian; Kollman, Justin M; Bhabha, Gira; Baker, David.

Nature ; 627(8005): 898-904, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38480887

8.

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

Wang, Lawrence T; Pereira, Lais S; Flores-Garcia, Yevel; O'Connor, James; Flynn, Barbara J; Schön, Arne; Hurlburt, Nicholas K; Dillon, Marlon; Yang, Annie S P; Fabra-García, Amanda; Idris, Azza H; Mayer, Bryan T; Gerber, Monica W; Gottardo, Raphael; Mason, Rosemarie D; Cavett, Nicole; Ballard, Reid B; Kisalu, Neville K; Molina-Cruz, Alvaro; Nelson, Jorgen; Vistein, Rachel; Barillas-Mury, Carolina; Amino, Rogerio; Baker, David; King, Neil P; Sauerwein, Robert W; Pancera, Marie; Cockburn, Ian A; Zavala, Fidel; Francica, Joseph R; Seder, Robert A.

Immunity ; 53(4): 733-744.e8, 2020 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-32946741

9.

High-resolution microtubule structures reveal the structural transitions in αß-tubulin upon GTP hydrolysis.

Alushin, Gregory M; Lander, Gabriel C; Kellogg, Elizabeth H; Zhang, Rui; Baker, David; Nogales, Eva.

Cell ; 157(5): 1117-29, 2014 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-24855948

10.

A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells.

Procko, Erik; Berguig, Geoffrey Y; Shen, Betty W; Song, Yifan; Frayo, Shani; Convertine, Anthony J; Margineantu, Daciana; Booth, Garrett; Correia, Bruno E; Cheng, Yuanhua; Schief, William R; Hockenbery, David M; Press, Oliver W; Stoddard, Barry L; Stayton, Patrick S; Baker, David.

Cell ; 157(7): 1644-1656, 2014 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-24949974

11.

De novo design of luciferases using deep learning.

Yeh, Andy Hsien-Wei; Norn, Christoffer; Kipnis, Yakov; Tischer, Doug; Pellock, Samuel J; Evans, Declan; Ma, Pengchen; Lee, Gyu Rie; Zhang, Jason Z; Anishchenko, Ivan; Coventry, Brian; Cao, Longxing; Dauparas, Justas; Halabiya, Samer; DeWitt, Michelle; Carter, Lauren; Houk, K N; Baker, David.

Nature ; 614(7949): 774-780, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36813896

12.

De novo design of modular peptide-binding proteins by superhelical matching.

Wu, Kejia; Bai, Hua; Chang, Ya-Ting; Redler, Rachel; McNally, Kerrie E; Sheffler, William; Brunette, T J; Hicks, Derrick R; Morgan, Tomos E; Stevens, Tim J; Broerman, Adam; Goreshnik, Inna; DeWitt, Michelle; Chow, Cameron M; Shen, Yihang; Stewart, Lance; Derivery, Emmanuel; Silva, Daniel Adriano; Bhabha, Gira; Ekiert, Damian C; Baker, David.

Nature ; 616(7957): 581-589, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-37020023

13.

Unraveling the functional dark matter through global metagenomics.

Pavlopoulos, Georgios A; Baltoumas, Fotis A; Liu, Sirui; Selvitopi, Oguz; Camargo, Antonio Pedro; Nayfach, Stephen; Azad, Ariful; Roux, Simon; Call, Lee; Ivanova, Natalia N; Chen, I Min; Paez-Espino, David; Karatzas, Evangelos; Iliopoulos, Ioannis; Konstantinidis, Konstantinos; Tiedje, James M; Pett-Ridge, Jennifer; Baker, David; Visel, Axel; Ouzounis, Christos A; Ovchinnikov, Sergey; Buluç, Aydin; Kyrpides, Nikos C.

Nature ; 622(7983): 594-602, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37821698

14.

De novo design of protein structure and function with RFdiffusion.

Watson, Joseph L; Juergens, David; Bennett, Nathaniel R; Trippe, Brian L; Yim, Jason; Eisenach, Helen E; Ahern, Woody; Borst, Andrew J; Ragotte, Robert J; Milles, Lukas F; Wicky, Basile I M; Hanikel, Nikita; Pellock, Samuel J; Courbet, Alexis; Sheffler, William; Wang, Jue; Venkatesh, Preetham; Sappington, Isaac; Torres, Susana Vázquez; Lauko, Anna; De Bortoli, Valentin; Mathieu, Emile; Ovchinnikov, Sergey; Barzilay, Regina; Jaakkola, Tommi S; DiMaio, Frank; Baek, Minkyung; Baker, David.

Nature ; 620(7976): 1089-1100, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37433327

15.

The road to fully programmable protein catalysis.

Lovelock, Sarah L; Crawshaw, Rebecca; Basler, Sophie; Levy, Colin; Baker, David; Hilvert, Donald; Green, Anthony P.

Nature ; 606(7912): 49-58, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35650353

16.

Cryo-EM structure of a type IV secretion system.

Macé, Kévin; Vadakkepat, Abhinav K; Redzej, Adam; Lukoyanova, Natalya; Oomen, Clasien; Braun, Nathalie; Ukleja, Marta; Lu, Fang; Costa, Tiago R D; Orlova, Elena V; Baker, David; Cong, Qian; Waksman, Gabriel.

Nature ; 607(7917): 191-196, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35732732

17.

Design of protein-binding proteins from the target structure alone.

Cao, Longxing; Coventry, Brian; Goreshnik, Inna; Huang, Buwei; Sheffler, William; Park, Joon Sung; Jude, Kevin M; Markovic, Iva; Kadam, Rameshwar U; Verschueren, Koen H G; Verstraete, Kenneth; Walsh, Scott Thomas Russell; Bennett, Nathaniel; Phal, Ashish; Yang, Aerin; Kozodoy, Lisa; DeWitt, Michelle; Picton, Lora; Miller, Lauren; Strauch, Eva-Maria; DeBouver, Nicholas D; Pires, Allison; Bera, Asim K; Halabiya, Samer; Hammerson, Bradley; Yang, Wei; Bernard, Steffen; Stewart, Lance; Wilson, Ian A; Ruohola-Baker, Hannele; Schlessinger, Joseph; Lee, Sangwon; Savvides, Savvas N; Garcia, K Christopher; Baker, David.

Nature ; 605(7910): 551-560, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35332283

18.

The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.

Patel, Saroor A; Hirosue, Shoko; Rodrigues, Paulo; Vojtasova, Erika; Richardson, Emma K; Ge, Jianfeng; Syafruddin, Saiful E; Speed, Alyson; Papachristou, Evangelia K; Baker, David; Clarke, David; Purvis, Stephenie; Wesolowski, Ludovic; Dyas, Anna; Castillon, Leticia; Caraffini, Veronica; Bihary, Dóra; Yong, Cissy; Harrison, David J; Stewart, Grant D; Machiela, Mitchell J; Purdue, Mark P; Chanock, Stephen J; Warren, Anne Y; Samarajiwa, Shamith A; Carroll, Jason S; Vanharanta, Sakari.

Nature ; 606(7916): 999-1006, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35676472

19.

Accurate prediction of protein-nucleic acid complexes using RoseTTAFoldNA.

Baek, Minkyung; McHugh, Ryan; Anishchenko, Ivan; Jiang, Hanlun; Baker, David; DiMaio, Frank.

Nat Methods ; 21(1): 117-121, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37996753

20.

Role of the biomolecular energy gap in protein design, structure, and evolution.

Fleishman, Sarel J; Baker, David.

Cell ; 149(2): 262-73, 2012 Apr 13.

Artigo em Inglês | MEDLINE | ID: mdl-22500796

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