Detalhe da pesquisa
1.
The Role of IFITM Proteins in Tick-Borne Encephalitis Virus Infection.
J Virol
; 96(1): e0113021, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34613785
2.
Characterizing the Pharmacokinetics and Biodistribution of Therapeutic Proteins: An Industry White Paper.
Drug Metab Dispos
; 50(6): 858-866, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149542
3.
Hydrogen deuterium exchange mass spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody.
Biochem J
; 478(1): 99-120, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33284343
4.
The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276.
Cell Mol Biol Lett
; 25: 41, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32874188
5.
Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.
Drug Metab Dispos
; 47(6): 648-656, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940629
6.
Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties.
J Chem Phys
; 148(14): 145101, 2018 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29655319
7.
Protein-Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP).
Mol Cell Proteomics
; 14(11): 2973-87, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26330542
8.
Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein-protein interactions by the MDM2 ligand nutlin-3.
Proteomics
; 16(17): 2327-44, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27273042
9.
Insights into the conformations of three structurally diverse proteins: cytochrome c, p53, and MDM2, provided by variable-temperature ion mobility mass spectrometry.
Anal Chem
; 87(6): 3231-8, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25629302
10.
Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay.
Proc Natl Acad Sci U S A
; 109(21): 8073-8, 2012 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22556265
11.
A physiologically based modeling strategy during preclinical CNS drug development.
Mol Pharm
; 11(3): 836-48, 2014 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24446829
12.
DNA-binding regulates site-specific ubiquitination of IRF-1.
Biochem J
; 449(3): 707-17, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23134341
13.
Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human.
Biopharm Drug Dispos
; 35(8): 485-99, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25044007
14.
The association of tadalafil exposure with lower rates of major adverse cardiovascular events and mortality in a general population of men with erectile dysfunction.
Clin Cardiol
; 47(2): e24234, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38377018
15.
FISH analysis reveals CDKN2A and IFNA14 co-deletion is heterogeneous and is a prominent feature of glioblastoma.
Brain Tumor Pathol
; 41(1): 4-17, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38097874
16.
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry.
Proteomics
; 13(16): 2512-25, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23776060
17.
Strategies for clinical dose optimization of T cell-engaging therapies in oncology.
MAbs
; 15(1): 2181016, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36823042
18.
Multiplex Bioanalytical Methods for Comprehensive Characterization and Quantification of the Unique Complementarity-Determining-Region Deamidation of MEDI7247, an Anti-ASCT2 Pyrrolobenzodiazepine Antibody-Drug Conjugate.
Antibodies (Basel)
; 12(4)2023 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37873863
19.
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Clin Cancer Res
; 29(6): 1086-1101, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355054
20.
An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis.
J Proteome Res
; 11(11): 5464-78, 2012 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23039052