Detalhe da pesquisa
1.
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy.
Annu Rev Pharmacol Toxicol
; 64: 89-114, 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37722720
2.
Model learning to identify systemic regulators of the peripheral circadian clock.
Bioinformatics
; 37(Suppl_1): i401-i409, 2021 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34252929
3.
Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy.
PLoS Comput Biol
; 16(1): e1007218, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31986133
4.
BMAL1 Knockdown Leans Epithelial-Mesenchymal Balance toward Epithelial Properties and Decreases the Chemoresistance of Colon Carcinoma Cells.
Int J Mol Sci
; 22(10)2021 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34065633
5.
Systems Chronotherapeutics.
Pharmacol Rev
; 69(2): 161-199, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28351863
6.
Quantitative Systems Pharmacology: A Foundation To Establish Precision Medicine-Editorial.
J Pharmacol Exp Ther
; 387(1): 27-30, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37714689
7.
Systems Biology, Systems Medicine, Systems Pharmacology: The What and The Why.
Acta Biotheor
; 66(4): 345-365, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29744615
8.
Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization.
PLoS Comput Biol
; 9(4): e1003011, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23592961
9.
Early morning immune checkpoint blockade and overall survival of patients with metastatic cancer: An In-depth chronotherapeutic study.
Eur J Cancer
; 199: 113571, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301362
10.
Association between endocrine adjuvant therapy intake timing and disease-free survival in patients with high-risk early breast cancer: results of a sub-study of the UCBG- UNIRAD trial.
EBioMedicine
; 104: 105141, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38718683
11.
Concomitant medication, comorbidity and survival in patients with breast cancer.
Nat Commun
; 15(1): 2966, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38580683
12.
Cell state-directed therapy - epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide.
CPT Pharmacometrics Syst Pharmacol
; 12(3): 360-374, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36642831
13.
Interspecies and in vitro-in vivo scaling for quantitative modeling of whole-body drug pharmacokinetics in patients: Application to the anticancer drug oxaliplatin.
CPT Pharmacometrics Syst Pharmacol
; 12(2): 221-235, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36537068
14.
Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress.
Life Sci Alliance
; 6(4)2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36746533
15.
A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery.
PLoS Comput Biol
; 7(9): e1002143, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21931543
16.
Sex and Circadian Timing Modulate Oxaliplatin Hematological and Hematopoietic Toxicities.
Pharmaceutics
; 14(11)2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36432655
17.
A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer.
Comput Struct Biotechnol J
; 19: 5170-5183, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34630937
18.
Sex-dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer: Randomized multicenter EORTC 05011 trial.
Cancer Med
; 9(12): 4148-4159, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32319740
19.
BMAL1 knockdown triggers different colon carcinoma cell fates by altering the delicate equilibrium between AKT/mTOR and P53/P21 pathways.
Aging (Albany NY)
; 12(9): 8067-8083, 2020 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32388500
20.
pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study.
Pharmacol Res Perspect
; 7(1): e00454, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30705757