Repetition frequency tunability and stability of BH InAs/InP QD and InGaAsP/InP QW two-section mode-locked laser diodes.

Ultra-high repetition rate (UHRR) mode-locked laser diodes (MLLD) have shown promising results for applications based on optical sampling such as asynchronous optical sampling (ASOPS), optical sampling by repetition-rate tuning (OSBERT), and optical ranging. Important metrics to consider are the repetition frequency (RF) and the RF linewidth. Here, we compare two monolithically integrated MLLDs. A quantum dot (QD) MLLD with an RF of approx. 50.1 GHz and a quantum well (QW) MLLD with an RF of approx. 51.4 GHz. The tunability of the RF is characterized by sweeping the lasers pump current, temperature, and saturable absorber (SA) reverse voltage. The QW MLLD has a tuning range of 31 MHz with an average RF linewidth of 53 kHz, while the QD MLLD has a smaller tuning range of 26 MHz with a higher average RF linewidth of 172 kHz.

Group velocity dispersion in high-performance BH InAs/InP QD and InGaAsP/InP QW two-section passively mode-locked lasers.

High-performance buried heterostructure (BH) C-band InAs/InP quantum dot (QD) and L-band InGaAsP/InP quantum well (QW) two-section passively mode-locked lasers (MLLs) are investigated. From the irregularity of the longitudinal mode spacing in the comb spectra, we confirm that under stable passive mode locking, both devices have strong group velocity dispersion (GVD) and corresponding GVD-induced pulse width broadening. After compensation with anomalous dispersion fibers (SMF-28), short pulse trains with sub-ps pulse widths are achieved for both devices. This observation demonstrates our ability to generate high peak power sub-ps pulses using QD MLLs and QW MLLs for many photonic applications of optical communications.

Ultra-High Repetition Rate Terahertz Time-Domain Spectroscopy for Micrometer Layer Thickness Measurement.

Terahertz time-domain spectroscopy systems driven by monolithic mode-locked laser diodes (MLLDs) exhibit bandwidths exceeding 1 THz and a peak dynamic range that can compete with other state-of-the-art systems. Their main difference compared to fiber-laser-driven systems is their ultra-high repetition rate of typically dozens of GHz. This makes them interesting for applications where the length of the terahertz path may not be precisely known and it enables the use of a very short and potentially fast optical delay unit. However, the phase accuracy of the system is limited by the accuracy with which the delay axes of subsequent measurements are synchronized. In this work, we utilize an all-fiber approach that uses the optical signal from the MLLD in a Mach-Zehnder interferometer to generate a reference signal that we use to synchronize the detected terahertz signals. We demonstrate transmission-mode thickness measurements of stacked layers of 17µm thick low-density polyethylene (LDPE) films.

Repeatability of material parameter extraction of liquids from transmission terahertz time-domain measurements.

Recently, many research groups worldwide have reported on the THz properties of liquids. Often these parameters, i.e., refractive index and absorption coefficient, are determined using liquids in cuvettes and terahertz time-domain spectroscopy. Here, we discuss the measurement process and determine how repeatable such measurements and the data extraction are using rapeseed oil as a sample. We address system stability, cuvette positioning, cuvette cleaning and cuvette assembly as sources affecting the repeatability. The results show that system stability and cuvette assembly are the most prominent factors limiting the repeatability of the THz measurements. These findings suggest that a single cuvette with precise positioning and thorough cleaning of the cuvette delivers the best discrimination among different liquid samples. Furthermore, when using a single cuvette and measurement systems of similar stability, the repeatability calculated based on several consecutive measurements is a good estimate to tell whether samples can be discriminated.

System-theoretical modeling of terahertz time-domain spectroscopy with ultra-high repetition rate mode-locked lasers.

Terahertz time-domain spectroscopy (THz-TDS) systems based on ultra-high repetition rate mode-locked laser diodes (MLLDs) and semiconductor photomixers show great potential in terms of a wide bandwidth, fast acquisition speed, compactness, and robustness. They come at a much lower total cost than systems using femtosecond fiber lasers. However, to date, there is no adequate mathematical description of THz-TDS using a MLLD. In this paper, we provide a simple formula based on a system-theoretical model that accurately describes the detected terahertz spectrum as a function of the optical amplitude and phase spectrum of the MLLD and the transfer function of the terahertz system. Furthermore, we give a simple yet exact relationship between the optical intensity autocorrelation and the detected terahertz spectrum. We theoretically analyze these results for typical optical spectra of MLLDs to quantify the effect of pulse chirp on the terahertz spectrum. Finally, we confirm the validity of the model with comprehensive experimental results using a single-section and a two-section MLLD in a conventional THz-TDS system.

Wideband Beam Steering Concept for Terahertz Time-Domain Spectroscopy: Theoretical Considerations.

Photonic true time delay beam steering on the transmitter side of terahertz time-domain spectroscopy (THz TDS) systems requires many wideband variable optical delay elements and an array of coherently driven emitters operating over a huge bandwidth. We propose driving the THz TDS system with a monolithic mode-locked laser diode (MLLD). This allows us to use integrated optical ring resonators (ORRs) whose periodic group delay spectra are aligned with the spectrum of the MLLD as variable optical delay elements. We show by simulation that a tuning range equal to one round-trip time of the MLLD is sufficient for beam steering to any elevation angle and that the loss introduced by the ORR is less than 0.1 dB. We find that the free spectral ranges (FSRs) of the ORR and the MLLD need to be matched to 0.01 % so that the pulse is not significantly broadened by third-order dispersion. Furthermore, the MLLD needs to be frequency-stabilized to about 100 MHz to prevent significant phase errors in the terahertz signal. We compare different element distributions for the array and show that a distribution according to a Golomb ruler offers both reasonable directivity and no grating lobes from 50 GHz to 1 THz.

Terahertz Beam Steering Concept Based on a MEMS-Reconfigurable Reflection Grating.

With an increasing number of applications of terahertz systems in industrial fields and communications, terahertz beamforming and beam steering techniques are required for high-speed, large-area scanning. As a promising means for beam steering, micro-electro-mechanical system (MEMS)-based reflection gratings have been successfully implemented for terahertz beam control. So far, the diffraction grating efficiency is relatively low due to the limited vertical displacement range of the reflectors. In this paper, we propose a design for a reconfigurable MEMS-based reflection grating consisting of multiple subwavelength reflectors which are driven by 5-bit, high-throw electrostatic actuators. We vary the number of the reflectors per grating period and configure the throw of individual reflectors so that the reflection grating is shaped as a blazed grating to steer the terahertz beam with maximum diffraction grating efficiency. Furthermore, we provide a mathematical model for calculating the radiation pattern of the terahertz wave reflected by general reflection gratings consisting of subwavelength reflectors. The calculated and simulated radiation patterns of the designed grating show that we can steer the angle of the terahertz waves in a range of up to ± 56.4 ∘ with a maximum sidelobe level of -10 dB at frequencies from 0.3 THz to 1 THz.

Enhancing the performance of THz quasi time-domain spectroscopy systems by low duty cycle laser operation.

We investigate the performance of terahertz (THz) quasi time-domain systems (QTDS) driven by electrically pulsed multi-mode laser diodes operating at 659 nm. We show that at the same average output power, a reduced duty cycle considerably increases the obtained bandwidth. In the presented experiment, the high frequency performance is improved by 50 dB/THz. We identify the broadening of the optical spectrum caused by pulsing the laser source to be responsible for the increased THz bandwidth.

Periodic sampling errors in terahertz time-domain measurements.

An extensive investigation of the origin and the impact of periodic sampling errors of terahertz time-domain spectroscopy systems is given. We present experimental findings and compare them to a theoretical model which is developed in this work. Special attention is given to the influence on the extraction of the refractive index from measurements. It can be shown that even distortions of the spectrum at frequencies higher than the used bandwidth can have a significant impact on the extracted refractive index.

Terahertz quasi time-domain spectroscopy based on telecom technology for 1550 nm.

We present a fiber-coupled terahertz quasi time-domain spectroscopy system driven by a laser with a central wavelength of 1550 nm. By using a commercially available multimode laser diode in combination with state-of-the-art continuous wave antennas, a bandwidth of more than 1.8 THz is achieved. The peak signal-to-noise ratio is around 60 dB. A simulation based on the optical spectrum of the laser diode and the transfer function of the THz path is in agreement with the experimental results. The system is used to extract the refractive index from two different samples and the results indicate that the performance is up to 1.8 THz comparable to a terahertz time-domain spectroscopy system.

Femtosecond semiconductor laser system with resonator-internal dispersion adaptation.

We present a femtosecond laser diode system that is capable of autonomously adjusting itself to compensate for the external dispersion in an arbitrary application. The laser system contains a spatial light modulator inside the cavity which is controlled by an evolutionary algorithm in order to allow for phase and amplitude shaping of the laser emission. The cavity-internal dispersion control is shown to be much more efficient than an external control with a pulse shaper.

Deep sedation Vs. general anesthesia in 232 patients undergoing percutaneous mitral valve repair using the MitraClip® system.

OBJECTIVES: To investigate in a series of 232 patients whether the MitraClip® procedure can be performed safely using deep sedation (DS) without general anesthesia (GA). BACKGROUND: Transcatheter mitral valve repair using the MitraClip® system is a safe and effective therapy for severe mitral regurgitation (MR) in patients who are at high operative risk or are unsuitable for surgery. For these patients, avoidance of GA might be beneficial. METHODS: Between 2011 and 2015, we performed 232 MitraClip® procedures for the treatment of severe MR. Of those, 76 procedures were performed using GA, while the remaining 156 procedures were performed using DS. RESULTS: Age, logistic EuroScore, severity of MR, left and right ventricular function, and renal function did not differ between the groups. The primary combined safety endpoint, which was defined as the occurrence of major adverse cardiac and cerebrovascular events, conversion to surgery, major vascular complications or pneumonia, did not differ between MitraClip® procedures performed using GA and MitraClip® procedures performed using DS. Intraprocedural conversion to GA was required in 2% of the patients in the DS group. There were no differences in procedural success or clinical outcome between the groups at the 3-month follow-up. Preparation time in the catheterization laboratory and intensive care unit (ICU) stay were shorter in the DS group compared to the GA group. CONCLUSION: The MitraClip® implantation performed using DS is as safe and effective as MitraClip® implantation performed using GA. © 2017 Wiley Periodicals, Inc.

Development of a multi-channel time-to-space terahertz spectrometer.

We present a compact sensor head for a multi-channel terahertz (THz) spectroscopy system. A THz pulse generated by a photoconductive antenna is split into spatially separated sub-pulses, which have different transit times. The time-dependent order of the sub-pulses can be translated into a spatial resolution. By using only one pair of antennas the developed sensor head provides up to 20 individual measurement zones with full amplitude and phase information. The sensor head can be integrated into two boxes with a small footprint so that the system is well suited for industrial applications.

Left Atrial and Left Ventricular Function and Remodeling Following Percutaneous Mitral Valve Repair.

BACKGROUND: Mitral regurgitation causes left atrial (LA) and left ventricular (LV) dysfunction, dilatation, and remodeling. Following percutaneous mitral valve repair (PMVR) using the MitraClip® approach, reverse cardiac remodeling is desirable. To date, the influence of PMVR on LA and segmental LV function and remodeling has not been investigated in detail. METHODS: Twenty-six patients who received the MitraClip device were enrolled in an open-label, single-center observational study. Patients underwent clinical assessment, conventional echocardiography and global and segmental longitudinal strain analysis of the left atrium and left ventricle by speckle tracking echocardiography at baseline and at a three-month follow up. RESULTS: PMVR improved both LV systolic function (from 40.5 ± 2.5% to 45.0 ± 2.5%, p = 0.04) and LV global longitudinal strain (from -8.9 ± 0.7% to -10.7 ± 0.9%, p = 0.004). Segmental analysis revealed improved myocardial deformation mainly in the basal (basalseptal -8.9 ± 0.8% to -12.9 ± 0.8%, p = 0.0002; basallateral -7.9 ± 1.1% to -13.9 ± 1.4%, p = 0.0005) and midventricular segments (mid-septal -12.7 ± 0.9% to -14.5 ± 1.1%, p = 0.02; mid-lateral -7.5 ± 0.8% to -10.8 ± 1.2%, p = 0.006). In patients with pre-procedural preserved LA function with sinus rhythm the impact of PMVR revealed an improvement in LA global conduit function (from 10.6 ± 1.2% to 13.9 ± 1.6%, p = 0.003) and global contractile function (from -2.1 ± 0.47% to -3.5 ± 0.5%, p = 0.03). The reversed remodeling was not associated with altered levels of the cardiac biomarkers matrix metalloproteinase 2 (MMP-2) and MMP-9, tissue-inhibitors of MMPs (TIMP-2 and ST-2). CONCLUSIONS: PMVR improves global segmental LV and LA function and leads to a reverse remodeling.

Self-optimizing femtosecond semiconductor laser.

A self-optimizing approach to intra-cavity spectral shaping of external cavity mode-locked semiconductor lasers using edge-emitting multi-section diodes is presented. An evolutionary algorithm generates spectrally resolved phase- and amplitude masks that lead to the utilization of a large part of the net gain spectrum for mode-locked operation. Using these masks as a spectral amplitude and phase filter, a bandwidth of the optical intensity spectrum of 3.7 THz is achieved and Fourier-limited pulses of 216 fs duration are generated after further external compression.

Influence of percutaneous mitral valve repair using the MitraClip® system on renal function in patients with severe mitral regurgitation.

BACKGROUND: In patients with mitral regurgitation (MR), changes in cardiac stroke volume, and thus renal preload and afterload may affect kidney function. Percutaneous mitral valve repair (PMVR) with the MitraClip® system can be a therapeutic alternative to surgical valve repair. The influence of MitraClip® therapy on renal function and clinical outcome parameters is unknown. METHODS AND RESULTS: Sixty patients with severe MR underwent PMVR using the MitraClip® system in an open-label observational study. Patients were stratified according to their renal function. All clips have been implanted successfully. Effective reduction of MR by 2-3 grades acutely improved KDOQI class. Lesser MR reduction (MR reduction of 0-1 grades) led to worsening of renal function in patients with pre-existing normal or mild (KDOQI 1-2) compared to severe (KDOQI 3-4) renal dysfunction. Reduction of MR was associated with improvement in Minnesota Living with Heart Failure Questionnaire (MLHFQ), NYHA-stadium, and 6-minute walk test. CONCLUSION: Successful PMVR was associated with an improvement in renal function. The improvement in renal function was associated with the extent of MR reduction and pre-existing kidney dysfunction. Our data emphasize the relevance of PVMR to stabilize the cardiorenal axis in patients with severe MR.

Left atrial appendage morphology is closely associated with specific echocardiographic flow pattern in patients with atrial fibrillation.

AIMS: To assess the relation between left atrial appendage (LAA) morphology and echocardiographic flow pattern of the LAA by means of two- and three-dimensional transoesophageal echocardiography (3D-TEE). METHODS AND RESULTS: In a total of 131 patients with atrial fibrillation, LAA morphology was analyzed by 3D-TEE and classified into four types (Chicken Wing, Windsock, Cactus, Cauliflower). Left atrial appendage flow pattern as maximal LAA emptying flow velocity and spontaneous echo contrast (SEC) were retrieved from 2D-TEE imaging in all patients. In patients with atrial fibrillation (AF), Chicken Wing morphology was associated with a higher LAA emptying flow velocity (difference of means = -11.7, 95% CI 4.6-19.3, P = 0.003) and a reduced prevalence of SEC (OR 3.2, 95% CI 1.1-9.3, P = 0.025) compared with all other LAA types (so-called 'Non-Chicken Wing' LAA). These alterations were irrespective of the underlying type of AF. CONCLUSION: Non-Chicken Wing LAA morphologies are associated with a specific echocardiographic flow pattern in patients with AF. Since evidence exists that LAA flow pattern are indicative of an enhanced risk of thrombus formation, 3D-TEE might be a valuable tool warranting future studies to test whether these morphological and functional characteristics permit risk stratification in AF.

Mode-locked semiconductor laser system with intracavity spatial light modulator for linear and nonlinear dispersion management.

We analyze the influence of second and third order intracavity dispersion on a passively mode-locked diode laser by introducing a spatial light modulator (SLM) into the external cavity. The dispersion is optimized for chirped pulses with highest possible spectral bandwidth that can be externally compressed to the sub picosecond range. We demonstrate that the highest spectral bandwidth is achieved for a combination of second and third order dispersion. With subsequent external compression pulses with a duration of 437 fs are generated.

Safety and efficacy of deep sedation as compared to general anaesthesia in percutaneous mitral valve repair using the MitraClip system.

OBJECTIVE: To characterize the safety and efficacy of deep sedation (DS) as compared to general anaesthesia (GA) in percutaneous mitral valve repair (PMVR) using the MitraClip system. BACKGROUND: PMVR with the MitraClip system has emerged as a therapeutic alternative to surgical valve repair in high-risk patients. The PMVR procedure is typically performed under GA. Due to their high surgical risk, avoidance of GA in many of those patients would be desirable. METHODS: In an open-label observational study 21 patients with severe mitral regurgitation were randomized to either GA or DS using propofol. Primary endpoints of this comparison were related to safety with rate of conversion from DS to GA, bleeding, aspiration, and pneumonia. Secondary endpoints were related to efficacy with procedural, in-hospital, and mid-term outcome at 1 month. RESULTS: All clips have been implanted successfully in both groups. No conversion from DS to GA was necessary. Four patients undergoing GA suffered from upper respiratory tract infections and two from peripheral vascular complications during placement of central venous catheter for GA. Short- and mid-term efficacy were comparable in both groups with a reduced hospital stay in the DS group. CONCLUSION: PVMR in high-risk patients performed under DS is as safe and effective as with GA, preventing complications related to GA and shortening hospital stay.

Laser diode based THz-TDS system with 133 dB peak signal-to-noise ratio at 100 GHz.

Terahertz time-domain spectroscopy (THz-TDS) has emerged as a powerful and versatile tool in various scientific fields. These include-among others-imaging, material characterization, and layer thickness measurements. While THz-TDS has achieved significant success in research environments, the high cost and bulky nature of most systems have hindered widespread commercialization of this technology. Two primary factors contributing to the size and cost of these systems are the laser and the optical delay unit (ODU). Consequently, our group has focused on developing THz-TDS systems based on compact monolithic mode-locked laser diodes (MLLDs). The ultra-high repetition rate (UHRR) of the MLLD has the added benefit that it allows us to utilize shorter ODUs, thereby reducing the overall cost and size of our systems. However, achieving the necessary precision in the ODU to acquire accurate terahertz time-domain signals remains a crucial aspect. To address this issue, we have developed and enhanced an interferometric extension for UHRR-THz-TDS systems. This extension is inexpensive, compact, and easy to incorporate. In this article, we present the system setup, the extension itself, and the algorithmic procedure for reconstructing the delay axis based on the interferometric reference signal. We evaluate a dataset comprising 10,000 signal traces and report a standard deviation of the measured terahertz phase at 1.6 THz as low as 3 mrad. Additionally, we demonstrate a remaining peak-to-peak jitter of only 20 fs and a record-high peak signal-to-noise ratio of 133 dB at 100 GHz after averaging. The method presented in this paper allows for simplified THz-TDS system builds, reducing bulk and cost. As a result, it further facilitates the transition of terahertz technologies from laboratory to field applications.