Detalhe da pesquisa
1.
Dynamic extracellular vestibule of human SERT: Unveiling druggable potential with high-affinity allosteric inhibitors.
Proc Natl Acad Sci U S A
; 120(41): e2304089120, 2023 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37792512
2.
Modeling and Mutational Analysis of the Binding Mode for the Multimodal Antidepressant Drug Vortioxetine to the Human 5-HT3A Receptor.
Mol Pharmacol
; 94(6): 1421-1434, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257860
3.
Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain.
Eur J Nucl Med Mol Imaging
; 44(2): 308-320, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27817159
4.
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.
Bioorg Med Chem Lett
; 27(3): 470-478, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28041833
5.
Synthesis and selective 2 H-, 13 C-, and 15 N-labeling of the Tau protein binder THK-523.
J Labelled Comp Radiopharm
; 60(1): 30-35, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27862198
6.
Neurokinin-3 Receptor Binding in Guinea Pig, Monkey, and Human Brain: In Vitro and in Vivo Imaging Using the Novel Radioligand, [18F]Lu AF10628.
Int J Neuropsychopharmacol
; 19(8)2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26993630
7.
Exploration of insights, opportunities and caveats provided by the X-ray structures of hSERT.
Bioorg Med Chem Lett
; 26(20): 5058-5064, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27624075
8.
Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.
Bioorg Med Chem Lett
; 25(6): 1212-6, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701253
9.
Synthesis and SAR study of a novel series of dopamine receptor agonists.
Bioorg Med Chem
; 22(1): 381-92, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24296012
10.
Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.
Proc Natl Acad Sci U S A
; 108(29): 12137-42, 2011 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21730142
11.
Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors.
Nat Struct Mol Biol
; 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38698207
12.
Discovery of novel α1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.
Bioorg Med Chem
; 21(1): 196-204, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23218776
13.
Characterization of the Novel P2X7 Receptor Radioligand [3H]JNJ-64413739 in Human Brain Tissue.
ACS Chem Neurosci
; 14(1): 111-118, 2023 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36535632
14.
Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004.
Drug Metab Dispos
; 40(7): 1357-65, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22496396
15.
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.
Bioorg Med Chem Lett
; 22(15): 5134-40, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22677319
16.
PET as a Translational Tool in Drug Development for Neuroscience Compounds.
Clin Pharmacol Ther
; 111(4): 774-785, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35201613
17.
Highly Specific and Sensitive Target Binding by the Humanized pS396-Tau Antibody hC10.2 Across a Wide Spectrum of Alzheimer's Disease and Primary Tauopathy Postmortem Brains.
J Alzheimers Dis
; 88(1): 207-228, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35570492
18.
Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody - The choice of chelator is essential.
Theranostics
; 12(16): 7067-7079, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36276653
19.
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.
J Biol Chem
; 285(3): 2051-63, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19892699
20.
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
Int J Neuropsychopharmacol
; 13(8): 1021-33, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20569520