Detalhe da pesquisa
1.
Single-dose euglycaemic clamp studies demonstrating pharmacokinetic and pharmacodynamic similarity between MK-1293 insulin glargine and originator insulin glargine (Lantus) in subjects with type 1 diabetes and healthy subjects.
Diabetes Obes Metab
; 20(2): 400-408, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28817223
2.
Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat.
Cardiovasc Diabetol
; 12: 148, 2013 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24125539
3.
Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers.
Br J Clin Pharmacol
; 76(1): 99-106, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23215699
4.
Efficacy and safety of itacitinib versus placebo in combination with corticosteroids for initial treatment of acute graft-versus-host disease (GRAVITAS-301): a randomised, multicentre, double-blind, phase 3 trial.
Lancet Haematol
; 9(1): e14-e25, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34971577
5.
Effect of Hepatic Impairment on the Pharmacokinetics of Itacitinib.
J Clin Pharmacol
; 61(7): 954-960, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33434286
6.
Evaluation of Clinical Cardiac Safety of Itacitinib, a JAK1 Inhibitor, in Healthy Participants.
Clin Pharmacol Drug Dev
; 9(6): 677-688, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31821750
7.
The Effect of Renal Impairment on the Pharmacokinetics and Safety of Itacitinib.
J Clin Pharmacol
; 60(8): 1022-1029, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32149388
8.
Effect of Itraconazole or Rifampin on Itacitinib Pharmacokinetics When Administered Orally in Healthy Subjects.
J Clin Pharmacol
; 59(12): 1641-1647, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31282592
9.
Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction.
JACC Heart Fail
; 4(7): 559-566, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27039125
10.
Utility of concentration-effect modeling and simulation in a thorough QT study of losmapimod.
J Clin Pharmacol
; 55(6): 661-70, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25612153
11.
Population pharmacokinetic modeling and simulation of amprenavir following fosamprenavir/ritonavir administration for dose optimization in HIV infected pediatric patients.
J Clin Pharmacol
; 54(2): 206-14, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25272370
12.
Practical considerations for dose selection in pediatric patients to ensure target exposure requirements.
AAPS J
; 16(4): 749-55, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841797
13.
Application of pharmacokinetic/pharmacodynamic modelling and simulation for the prediction of target attainment of ceftobiprole against meticillin-resistant Staphylococcus aureus using minimum inhibitory concentration and time-kill curve based approaches.
Int J Antimicrob Agents
; 43(1): 60-7, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24183800
14.
Infusions Are the Optimal Dosing Method in Intravenous ADME Studies Rather Than Bolus Dosing.
J Clin Pharmacol
; 58(1): 25-28, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28815729
15.
Antibiotics Development and the Emergence of Resistance: Clinical Pharmacology to the Rescue.
J Clin Pharmacol
; 58(4): 409-411, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29329481