Detalhe da pesquisa
1.
A Caenorhabditis elegans model of autosomal dominant adult-onset neuronal ceroid lipofuscinosis identifies ethosuximide as a potential therapeutic.
Hum Mol Genet
; 32(11): 1772-1785, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36282524
2.
Tissue distribution of cysteine string protein/DNAJC5 in C. elegans analysed by CRISPR/Cas9-mediated tagging of endogenous DNJ-14.
Cell Tissue Res
; 396(1): 41-55, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38403745
3.
Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension.
Biochem J
; 478(24): 4153-4167, 2021 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34661239
4.
Functional analysis of epilepsy-associated variants in STXBP1/Munc18-1 using humanized Caenorhabditis elegans.
Epilepsia
; 61(4): 810-821, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32112430
5.
α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy.
Neurobiol Dis
; 118: 40-54, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29940336
6.
Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.
Hum Mol Genet
; 23(22): 5916-27, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24947438
7.
Functional analysis of epilepsy-associated GABAA receptor mutations using Caenorhabditis elegans.
Epilepsia Open
; 2024 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38813985
8.
PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.
J Neurosci
; 32(20): 7042-51, 2012 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22593072
9.
C. elegans dkf-1 (Protein Kinase D1) mutants have age-dependent defects in locomotion and neuromuscular transmission.
MicroPubl Biol
; 20232023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37090152
10.
Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis.
Sci Rep
; 13(1): 20616, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996473
11.
Munc18-1 tuning of vesicle merger and fusion pore properties.
J Neurosci
; 31(24): 9055-66, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21677188
12.
Caenorhabditis elegans: a useful tool to decipher neurodegenerative pathways.
Biochem Soc Trans
; 38(2): 559-63, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20298221
13.
Presynaptic targets for acute ethanol sensitivity.
Biochem Soc Trans
; 38(Pt 1): 172-6, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20074054
14.
Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.
Biochem J
; 418(1): 73-80, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19032153
15.
A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins.
Genetics
; 180(1): 165-78, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757920
16.
A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3.
Biochem J
; 409(2): 407-16, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17919117
17.
S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding.
Biochem J
; 413(3): 479-91, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18452404
18.
Munc-18-1 regulates the initial release rate of exocytosis.
Biophys J
; 94(3): 1084-93, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17921224
19.
Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.
Mol Biol Cell
; 16(2): 470-82, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15563604
20.
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.
J Neurosci Methods
; 309: 132-142, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30189284