Detalhe da pesquisa
1.
Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface.
Biochem Soc Trans
; 49(5): 2253-2269, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34709394
2.
Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.
Biochem Soc Trans
; 46(6): 1559-1565, 2018 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30381336
3.
Atypical antigen recognition mode of a shark immunoglobulin new antigen receptor (IgNAR) variable domain characterized by humanization and structural analysis.
J Biol Chem
; 288(24): 17408-19, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23632026
4.
Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation.
J Mater Chem B
; 11(19): 4181-4190, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37092346
5.
Development of a cationic polyethyleneimine-poly(lactic-co-glycolic acid) nanoparticle system for enhanced intracellular delivery of biologics.
RSC Adv
; 13(48): 33721-33735, 2023 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38020041
6.
Data infrastructures for AI in medical imaging: a report on the experiences of five EU projects.
Eur Radiol Exp
; 7(1): 20, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37150779
7.
Aerodynamics of cyclist posture, bicycle and helmet characteristics in time trial stage.
J Appl Biomech
; 28(3): 317-23, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22084053
8.
Enhancing the Transdermal Delivery of 'Next Generation' Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study.
J Pharm Sci
; 111(12): 3362-3376, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037879
9.
Overview, Generation, and Significance of Variable New Antigen Receptors (VNARs) as a Platform for Drug and Diagnostic Development.
Methods Mol Biol
; 2446: 19-33, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35157267
10.
Non-Alcoholic Steatohepatitis (NASH) - A Review of a Crowded Clinical Landscape, Driven by a Complex Disease.
Drug Des Devel Ther
; 15: 3997-4009, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34588764
11.
Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.
Nat Commun
; 12(1): 7325, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34916516
12.
In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development.
J Immunol Res
; 2020: 7283239, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32090129
13.
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties.
Methods Mol Biol
; 2070: 115-142, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31625093
14.
Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature.
Nanoscale
; 12(27): 14751-14763, 2020 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32626858
15.
Shark novel antigen receptors--the next generation of biologic therapeutics?
Adv Exp Med Biol
; 655: 49-62, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-20047035
16.
An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model.
Front Immunol
; 10: 526, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30967865
17.
Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents.
Protein Eng Des Sel
; 32(9): 385-399, 2019 12 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32119084
18.
Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand.
Transl Vis Sci Technol
; 8(5): 11, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31588375
19.
Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance.
Chem Commun (Camb)
; 55(53): 7671-7674, 2019 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31204425
20.
Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo.
J Antimicrob Chemother
; 61(2): 315-22, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18033783