RESUMO
INTRODUCTION: The rapid advancement of artificial intelligence and big data analytics, including descriptive, diagnostic, predictive, and prescriptive analytics, has the potential to revolutionize many areas of medicine, including nephrology and dialysis. Artificial intelligence and big data analytics can be used to analyze large amounts of patient medical records, including laboratory results and imaging studies, to improve the accuracy of diagnosis, enhance early detection, identify patterns and trends, and personalize treatment plans for patients with kidney disease. Additionally, artificial intelligence and big data analytics can be used to identify patients' treatment who are not receiving adequate care, highlighting care inefficiencies in the dialysis provider, optimizing patient outcomes, reducing healthcare costs, and consequently creating values for all the involved stakeholders. OBJECTIVES: We present the results of a comprehensive survey aimed at exploring the attitudes of European physicians from eight countries working within a major hemodialysis network (Fresenius Medical Care NephroCare) toward the application of artificial intelligence in clinical practice. METHODS: An electronic survey on the implementation of artificial intelligence in hemodialysis clinics was distributed to 1,067 physicians. Of the 1,067 individuals invited to participate in the study, 404 (37.9%) professionals agreed to participate in the survey. RESULTS: The survey showed that a substantial proportion of respondents believe that artificial intelligence has the potential to support physicians in reducing medical malpractice or mistakes. CONCLUSION: While artificial intelligence's potential benefits are recognized in reducing medical errors and improving decision-making, concerns about treatment plan consistency, personalization, privacy, and the human aspects of patient care persist. Addressing these concerns will be crucial for successfully integrating artificial intelligence solutions in nephrology practice.
Assuntos
Inteligência Artificial , Nefrologia , Humanos , Nefrologistas , Diálise Renal , Inquéritos e QuestionáriosRESUMO
INTRODUCTION: The Anemia Control Model (ACM) is a certified medical device suggesting the optimal ESA and iron dosage for patients on hemodialysis. We sought to assess the effectiveness and safety of ACM in a large cohort of hemodialysis patients. METHODS: This is a retrospective study of dialysis patients treated in NephroCare centers between June 1, 2013 and December 31, 2019. We compared patients treated according to ACM suggestions and patients treated in clinics where ACM was not activated. We stratified patients belonging to the reference group by historical target achievement rates in their referral centers (tier 1: <70%; tier 2: 70-80%; tier 3: >80%). Groups were matched by propensity score. RESULTS: After matching, we obtained four groups with 85,512 patient-months each. ACM had 18% higher target achievement rate, 63% smaller inappropriate ESA administration rate, and 59% smaller severe anemia risk compared to Tier 1 centers (all p < 0.01). The corresponding risk ratios for ACM compared to Tier 2 centers were 1.08 (95% CI: 1.08-1.09), 0.49 (95% CI: 0.47-0.51), and 0.64 (95% CI: 0.61-0.68); for ACM compared to Tier 3 centers, 1.01 (95% CI: 1.01-1.02), 0.66 (95% CI: 0.63-0.69), and 0.94 (95% CI: 0.88-1.00), respectively. ACM was associated with statistically significant reductions in ESA dose administration. CONCLUSION: ACM was associated with increased hemoglobin target achievement rate, decreased inappropriate ESA usage and a decreased incidence of severe anemia among patients treated according to ACM suggestion.
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Anemia , Eritropoetina , Hematínicos , Humanos , Diálise Renal/efeitos adversos , Hematínicos/uso terapêutico , Hematínicos/efeitos adversos , Estudos Retrospectivos , Anemia/tratamento farmacológico , Anemia/etiologia , Eritropoetina/uso terapêutico , Eritropoetina/efeitos adversos , Hemoglobinas/análiseRESUMO
BACKGROUND: Cold hemodialysis (HD) prevented intradialysis hypotension (IDH) in small, short-term, randomized trials in selected patients with IDH. Whether this treatments prevents IDH and mortality in the HD population at large is unknown. METHODS: We investigated the relationship between dialysate temperature and the risk of IDH, i.e. nadir blood pressure <90 mmHg (generalized estimating equation model) and all-cause mortality (Cox's regression) in an incident cohort of HD patients (n = 8071). To control for confounding by bias by indication and other factors we applied instrumental variables adjusting for case mix at facility level. RESULTS: Twenty-seven percent of patients in the study cohort were systematically treated with a dialysate temperature ≤35.5°C. Over a median follow-up of 13.6 months (interquartile range 5.2-26.1 months), a 0.5°C reduction of the dialysate temperature was associated with a small (-2.4%) reduction of the risk of IDH [odds ratio (OR) 0.976, 95% confidence interval (CI) 0.957-0.995, P = .013]. In case-mix, facility-level adjusted analysis, the association became much stronger (OR 0.67, 95% CI 0.63-0.72, risk reduction = 33%, P < .001). In contrast, colder dialysate temperature had no effect on mortality both in the unadjusted [hazard ratio (HR) (0.5°C decrease) 1.074, 95% CI 0.972-1.187, P = .16] and case-mix-adjusted analysis at facility level (HR 1.01, 95% CI 0.88-1.16, P = .84). Similar results were registered in additional analyses by instrumental variables applying the median dialysate temperature or the facility percentage of patients prescribed a dialysate temperature <36°C. Further analyses restricted to patients with recurrent IDH fully confirmed these findings. CONCLUSIONS: Cold HD was associated with IDH in the HD population but had no association with all-cause mortality.
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Hipotensão , Falência Renal Crônica , Humanos , Hipotensão/etiologia , Hipotensão/prevenção & controle , Diálise Renal/efeitos adversos , Diálise Renal/métodos , Pressão Sanguínea , Soluções para Diálise , Falência Renal Crônica/terapia , Falência Renal Crônica/complicaçõesRESUMO
Existe una gran variedad de procedimientos y métodos, seguidos por los profesionales para realizar las curas y el cuidado del orificio de salida del catéter peritoneal. Averiguamos que todos ellos eran fundamentados y con resultados efectivos. Pero, nos preguntamos, ¿Cuál de entre ellos sería el más adecuado utilizar en nuestra unidad? Optamos por utilizar las recomendaciones de la literatura científica, incluyendo variables como las necesidades específicas de cada paciente, según las condiciones medioambientales de nuestra comunidad y las estaciones del año. El objetivo principal de nuestro estudio fue evaluar la validez y efectividad del protocolo que establecimos para nuestros pacientes. Realizamos un estudio epidemiológico descriptivo y longitudinal de 2 años y 8 meses de duración. Calculamos la tasa de incidencia de infecciones del orificio de salida del catéter y de peritonitis por paciente y para cada uno de los años de estudio (2008-2009- 2010). Evaluamos los resultados comparándolos con los índices de normalidad marcados por la Sociedad Española de Nefrología, en el año 2007. Desglosamos el total de infecciones según estaciones y calculamos el porcentaje. Diferenciamos entre las infecciones provocadas por bacterias gram+ y aquellas producidas por bacterias gram-. Los resultados obtenidos revelaron que nuestro protocolo es válido y adecuado para nuestros pacientes, obteniendo una tasa de incidencia global de peritonitis de 0.72 por cada 24 paciente-mes y una tasa de infección del orificio de salida de 0.61 paciente-año, ambas por debajo del estándar establecido por la Sociedad Española de Nefrología (2007). Se demostró una mayor incidencia de infecciones en el periodo estival, concretamente el 46%. La clorhexidina al 1% abarca la cobertura de las bacterias gram+, bacterias gram-, esporas, virus y hongos pero se comprueba su mayor efectividad con los microorganismos gram+ (AU)
There is a great variety of procedures and methods followed by the professionals who provide peritoneal catheter exit orifice care. We found that all of them had a sound basis and showed effective results. However, we asked ourselves which of them would be the most suitable to use in our unit. We opted to use the recommendations of scientific literature, including variables such as the specific needs of each patient, according to the environmental conditions of our community and the seasons of the year. The main objective of our study was to assess the validity and effectiveness of the protocol we had established for our patients. We carried out a descriptive and longitudinal epidemiological study lasting 2 years and 8 months. We calculated the incidence rate of catheter exit orifice infections and peritonitis per patient and for each of the years of the study (2008-2009-2010). We assessed the result by comparing them with the normality indices set by the Spanish Nephrology Association, in 2007. We broke down the total of infections according to seasons and calculated the percentage. We differentiated between infections caused by gram + and gram - bacteria. The results obtained showed that our protocol is valid and suitable for our patients, obtaining an overall peritonitis incidence rate of 0.72 for every 24 patient-months and an exit orifice infection rate of 0.61 patient-years, both of which are lower than the standard established by the Spanish Nephrology Association (2007). A higher incidence of infections was found in the summer period, specifically 46%. 1% chlorhexidine covers gram+ bacteria, grambacteria, spores, viruses and fungi but was found to be most effective with gram+ microorganisms (AU)