Detalhe da pesquisa
1.
Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey.
J Lipid Res
; 57(12): 2150-2162, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27707816
2.
The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing.
Nucleic Acids Res
; 38(14): 4788-97, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20360048
3.
Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9.
J Lipid Res
; 52(4): 679-87, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21262787
4.
siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.
J Lipid Res
; 52(6): 1084-1097, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21398511
5.
Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.
J Proteome Res
; 10(10): 4683-91, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21819150
6.
MicroRNA-like off-target transcript regulation by siRNAs is species specific.
RNA
; 15(2): 308-15, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19144911
7.
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.
Mol Cell Biol
; 27(6): 2092-102, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17220275
8.
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.
Mol Cell Biol
; 27(15): 5381-92, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17526729
9.
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression.
Mol Cell Biol
; 27(6): 2240-52, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17242205
10.
Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.
Mol Cell Biol
; 26(24): 9377-86, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17000754
11.
An efficient and fully automated high-throughput transfection method for genome-scale siRNA screens.
J Biomol Screen
; 13(2): 142-8, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18216392
12.
Median absolute deviation to improve hit selection for genome-scale RNAi screens.
J Biomol Screen
; 13(2): 149-58, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18216396
13.
DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
Cell Metab
; 27(6): 1236-1248.e6, 2018 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29706567
14.
Expression profiling reveals off-target gene regulation by RNAi.
Nat Biotechnol
; 21(6): 635-7, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12754523
15.
How will RNAi facilitate drug development?
Sci STKE
; 2005(295): pe39, 2005 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16077085
16.
Alterations in the hepatic transcriptional landscape after RNAi mediated ApoB silencing in cynomolgus monkeys.
Atherosclerosis
; 242(2): 383-95, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275376
17.
Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension.
Hypertens Res
; 37(5): 405-12, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24335718
18.
A multiplexed siRNA screening strategy to identify genes in the PARP pathway.
J Biomol Screen
; 17(10): 1316-28, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22786893
19.
Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFß.
Cell Cycle
; 10(15): 2540-8, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21720214
20.
MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.
Cell Cycle
; 8(17): 2756-68, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19652553