Detalhe da pesquisa
1.
CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration--in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a wide therapeutic window.
J Pharmacol Exp Ther
; 352(3): 568-78, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25576073
2.
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ß2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
J Med Chem
; 65(15): 10233-10250, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35901125
3.
Evaluation of lung inflammation induced by intratracheal administration of LPS in mice: comparison between MRI and histology.
MAGMA
; 23(2): 93-101, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20386954
4.
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2).
J Med Chem
; 50(7): 1693-7, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17352463
5.
Pharmacological assessment of the duration of action of glycopyrrolate vs tiotropium and ipratropium in guinea-pig and human airways.
Br J Pharmacol
; 148(3): 291-8, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16565730
6.
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
Eur J Pharmacol
; 519(3): 231-6, 2005 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16125167
7.
Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases.
J Med Chem
; 57(3): 793-816, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24400806
8.
Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives.
Bioorg Med Chem
; 14(10): 3263-74, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16460950
9.
Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain.
J Pharmacol Exp Ther
; 306(2): 804-14, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12750440