Detalhe da pesquisa
1.
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Bioorg Med Chem Lett
; 27(7): 1602-1607, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28258797
2.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Bioorg Med Chem
; 25(2): 545-556, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894589
3.
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.
J Pharmacol Exp Ther
; 353(2): 392-404, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25720766
4.
A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model.
BMC Cancer
; 15: 522, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26177924
5.
Identification of novel drugs to target dormant micrometastases.
BMC Cancer
; 15: 404, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25971923
6.
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Bioorg Med Chem
; 23(10): 2408-23, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25882519
7.
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Bioorg Med Chem
; 22(14): 3753-72, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24890652
8.
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Bioorg Med Chem
; 21(7): 1857-64, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434139
9.
Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia.
J Immunol Res
; 2019: 5087847, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31073533
10.
AG488 as a therapy against gliomas.
Oncotarget
; 8(42): 71833-71844, 2017 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29069750
11.
AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.
Cancer Lett
; 388: 149-157, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27939695
12.
Targeting dormant micrometastases: rationale, evidence to date and clinical implications.
Ther Adv Med Oncol
; 8(2): 126-37, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26929788
13.
Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.
ACS Med Chem Lett
; 5(5): 480-4, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900865
14.
Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression.
PLoS One
; 9(5): e98624, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24878664