Detalhe da pesquisa
1.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother
; 66(6): e0013222, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35607978
2.
Bosutinib prevents vascular leakage by reducing focal adhesion turnover and reinforcing junctional integrity.
J Cell Sci
; 133(9)2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32198280
3.
Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.
Bioorg Med Chem Lett
; 28(22): 3529-3533, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30316633
4.
Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.
Antimicrob Agents Chemother
; 59(2): 753-62, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25385118
5.
Synthesis of Enantiopure 3-Hydroxypiperidines from Sulfinyl Dienyl Amines by Diastereoselective Intramolecular Cyclization and [2,3]-Sigmatropic Rearrangement.
J Org Chem
; 80(15): 7674-92, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26162504
6.
αß,α'ß'-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes.
Chem Commun (Camb)
; 59(86): 12859-12862, 2023 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37815791
7.
High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
Chem Sci
; 14(26): 7262-7278, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37416715
8.
An approach to the stereoselective synthesis of enantiopure dihydropyrroles and aziridines from a common sulfinyl-sulfinamide intermediate.
J Org Chem
; 77(1): 525-42, 2012 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22088141
9.
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Nat Commun
; 13(1): 5992, 2022 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220877
10.
Identification of ß-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions.
ACS Infect Dis
; 8(3): 557-573, 2022 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35192346
11.
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J Med Chem
; 65(1): 409-423, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34910486
12.
Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-ß-d-Ribose Oxidase (DprE1) Inhibitors.
J Med Chem
; 63(10): 5367-5386, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32342688
13.
Exploring the SAR of the ß-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
ACS Infect Dis
; 6(5): 1098-1109, 2020 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32196311
14.
Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis.
ACS Med Chem Lett
; 10(10): 1423-1429, 2019 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620228
15.
Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocyles.
Curr Opin Drug Discov Devel
; 11(6): 778-92, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18946843
16.
Pharmacokinetics of ß-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.
ACS Infect Dis
; 4(10): 1439-1447, 2018 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30141902
17.
In vivo potent BM635 analogue with improved drug-like properties.
Eur J Med Chem
; 145: 539-550, 2018 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29335214
18.
Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors.
J Med Chem
; 61(24): 11221-11249, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30500189
19.
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Nat Commun
; 9: 16227, 2018 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004092
20.
Pharmaceutical salt of BM635 with improved bioavailability.
Eur J Pharm Sci
; 99: 17-23, 2017 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27939618