Detalhe da pesquisa
1.
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.
Acta Neuropathol
; 144(3): 437-464, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876881
2.
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
EMBO J
; 35(15): 1656-76, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27334615
3.
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.
Brain
; 142(3): 586-605, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30698736
4.
Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.
Hum Mol Genet
; 26(23): 4668-4679, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28973175
5.
α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage.
J Neurosci
; 33(42): 16412-26, 2013 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24133248
6.
The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.
Proc Natl Acad Sci U S A
; 107(4): 1654-9, 2010 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20080692
7.
A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.
Sci Transl Med
; 15(685): eabo3823, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36857431
8.
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
Front Cell Neurosci
; 16: 1061559, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36619668
9.
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.
Anesthesiology
; 115(1): 144-52, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21602662
10.
The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.
J Neurosci
; 29(13): 4076-88, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339603
11.
The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo.
Biochem Soc Trans
; 38(2): 525-8, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20298215
12.
Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain.
Mol Pain
; 5: 45, 2009 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19664204
13.
Potentiation of exocytosis by phospholipase C-coupled G-protein-coupled receptors requires the priming protein Munc13-1.
J Neurosci
; 27(1): 212-9, 2007 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17202488
14.
Differential regulation of endogenous N- and P/Q-type Ca2+ channel inactivation by Ca2+/calmodulin impacts on their ability to support exocytosis in chromaffin cells.
J Neurosci
; 27(19): 5236-48, 2007 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17494710
15.
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Nat Commun
; 8: 16063, 2017 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28677678
16.
Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels.
Elife
; 52016 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27782881
17.
Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.
Pain
; 155(3): 522-533, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24315988
18.
Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture.
Channels (Austin)
; 6(2): 124-32, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22627148
19.
A new look at calcium channel α2δ subunits.
Curr Opin Neurobiol
; 20(5): 563-71, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20579869
20.
Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2.
Nature
; 419(6910): 947-52, 2002 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-12410316