Detalhe da pesquisa
1.
An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2.
Toxicol Appl Pharmacol
; 443: 116006, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35367236
2.
Concentration-QTcF Modeling of Icenticaftor from a Randomized, Placebo- and Positive-Controlled Thorough QT Study in Healthy Participants.
Clin Pharmacol Drug Dev
; 13(5): 572-584, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38284433
3.
Relative Bioavailability and Food Effect of Asciminib Pediatric Mini-tablet Formulation Compared to the Reference Tablet Formulation in Healthy Adult Participants.
Clin Pharmacol Drug Dev
; 12(5): 484-492, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36622274
4.
Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development.
EBioMedicine
; 80: 104065, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35598441
5.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Sci Transl Med
; 13(603)2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290058
6.
Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial.
Lancet Infect Dis
; 20(8): 964-975, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32275867
7.
Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study.
Lancet Infect Dis
; 17(6): 626-635, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28363636
8.
In vivo antioxidative activity of a quantified Pueraria lobata root extract.
J Ethnopharmacol
; 127(1): 112-7, 2010 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19799984
9.
Development and validation of an HPLC method for quality control of Pueraria lobata flower.
Planta Med
; 73(15): 1606-13, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18067064