Detalhe da pesquisa
1.
Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice.
J Cell Biochem
; 116(9): 2109-19, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25808283
2.
Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody.
J Pharmacol Exp Ther
; 353(1): 35-43, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25613982
3.
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.
Am J Physiol Endocrinol Metab
; 304(11): E1175-87, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23512805
4.
Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.
J Biol Chem
; 285(27): 20607-14, 2010 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20410301
5.
Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators.
Mol Cell Endocrinol
; 415: 143-56, 2015 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26277398
6.
Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders.
J Diabetes Sci Technol
; 8(4): 865-73, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24876415
7.
Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.
PLoS One
; 9(2): e88684, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24533136
8.
Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.
MAbs
; 6(1): 262-72, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24423625
9.
Discovery of diverse and functional antibodies from large human repertoire antibody libraries.
J Immunol Methods
; 391(1-2): 60-71, 2013 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23454004
10.
A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control.
Diabetes
; 61(5): 1263-71, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22403294