Short-Term Health Impact Assessment of Urban PM10 in Bejaia City (Algeria).

We used Health Impact Assessment (HIA) to analyze the impact on a given population's health outcomes in terms of all-causes mortality and respiratory and cardiovascular hospitalizations attributable to short-term exposure to particulate matter less than 10 µm diameter (PM10) in Bejaia city, for which health effects of air pollution have never been investigated. Two scenarios of PM10 reduction were considered: first, a scenario where the PM10 annual mean is decreased by 5 µg/m(3), and then a scenario where this PM10 mean is decreased to 20 µg/m(3) (World Health Organization annual air quality guideline (WHO-AQG)). Annual mean level of PM10 (81.7 µg/m(3)) was calculated from objective measurements assessed in situ. Each year, about 4 and 55 deaths could be postponed with the first and the second scenarios successfully. Furthermore, decreasing PM10 annual mean by 5 µg/m(3) would avoid 5 and 3 respiratory and cardiac hospitalizations, respectively, and not exceeding the PM10 WHO-AQG (20 µg/m(3)) would result in a potential gain of 36 and 23 per 100000 respiratory and cardiac hospitalizations, respectively. Lowering in current levels of PM10 has a nonnegligible impact in terms of public health that it is expected to be higher in the case of long-term effects.

Association analysis of the IL-1 gene cluster polymorphisms with aggressive and chronic periodontitis in the Algerian population.

OBJECTIVE: There is strong evidence that genetic as well as environmental factors affect the development of periodontitis. Various studies suggest that genetic polymorphisms of the interleukin-1 (IL-1) genes are associated with an increased risk of developing the pathogenesis. The aim of the present study was to investigate the possible relationship between two polymorphisms of IL-1 gene cluster IL-1B (C+3954T) (rs1143634) and IL-1A (C-889T) (rs1800587) SNPs and the aggressive and chronic periodontitis risk in a case control study in Algerian population. METHODS: 279 subjects were recruited and received a periodontal examination: 128 healthy controls and 151 cases. From cases, 91 patients were having a chronic disease whereas 60 subjects with aggressive form. All these subjects were genotyped for IL-1A (C-889T) and IL-1B (C+3954T) polymorphisms using TaqMan real time PCR technology. Frequencies of IL-1 alleles, genotypes and the haplotypes were also examined. RESULTS: Significant differences were found in the carriage rate of both minor alleles of the IL-1A (C-889T) and IL-1B (C+3954T) polymorphisms of aggressive periodontitis cases compared with healthy controls (OR [95%CI]=1.61 [1.03-2.49], p=0.03), (OR [95%CI]=1.69 [1.09-2.63], p=0.01), respectively. The result did not reach significance with the chronic form. CONCLUSION: The studied polymorphisms of the IL-1 genes appear to be associated with susceptibility to aggressive periodontitis (AgP) in the Algerian population.

Assessment of Air Pollution Impacts on Population Health in Bejaia City, Northern Algeria.

BACKGROUND: To assess the health impact of air pollution on Bejaia population in the north of Algeria, we carried out a descriptive epidemiologic inquiry near the medical establishments of three areas. METHODS: From hospital admissions registers, we collected data on the hospital mortality and admissions relating to the various cardiorespiratory pathologies generated by this type of pollution. In parallel, data on the automobile fleet of Bejaia and other measurements were exploited to show that the pollutants concentrations are strongly correlated with the urban traffic concentration. RESULTS: This study revealed that the whole of the population is touched, but the sensitivity to pollution can show variations according to the age, the sex and the residence place. Population of Bejaia town marked the most raised death and morbidity rates, followed by that of Kherrata. Weak rates are recorded for the rural population of Feraoun. Stronger correlation (>0.9) is evident amongst CO and deaths due to asthma and COPD in Béjaia city. CONCLUSION: This approach enables us to conclude that the population of Béjaia could not escape the urban pollution generated by her old automobile fleet. Installation of a monitoring and measuring site of air pollution in this city could provide a beneficial tool to protect its inhabitants by informing on air quality they breathe and the measures to following order to minimize the impacts on their health and by alerting the authorities during the critical situations.