Detalhe da pesquisa
1.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Cell
; 160(1-2): 88-104, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25594176
2.
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Proc Natl Acad Sci U S A
; 118(27)2021 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34187898
3.
Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance.
J Neurosci
; 36(12): 3531-40, 2016 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27013681
4.
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.
Hum Mol Genet
; 23(18): 4995-5008, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24833719
5.
Ptp1b deletion in pro-opiomelanocortin neurons increases energy expenditure and impairs endothelial function via TNF-α dependent mechanisms.
Clin Sci (Lond)
; 130(11): 881-93, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26935109
6.
Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling.
J Biol Chem
; 289(46): 31682-31692, 2014 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288805
7.
Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension.
Pharmacol Res
; 102: 235-44, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26523876
8.
Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.
Proc Natl Acad Sci U S A
; 109(47): 19226-31, 2012 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23129613
9.
GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner.
Cell Mol Gastroenterol Hepatol
; 17(2): 279-291, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-37844795
10.
Neuronal PTP1B regulates body weight, adiposity and leptin action.
Nat Med
; 12(8): 917-24, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16845389
11.
Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids.
Mol Metab
; 78: 101830, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38787338
12.
Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr-/-.Leiden mice.
Heliyon
; 9(3): e13985, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36915476
13.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Am J Physiol Endocrinol Metab
; 303(5): E644-51, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22761160
14.
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals.
Am J Physiol Endocrinol Metab
; 303(4): E496-503, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22693203
15.
Melanocortin control of energy balance: evidence from rodent models.
Cell Mol Life Sci
; 68(15): 2569-88, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21553232
16.
Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.
Biochem J
; 438(2): 369-78, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21605081
17.
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
Am J Physiol Endocrinol Metab
; 300(6): E1002-11, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21406615
18.
Metabolic drivers of non-alcoholic fatty liver disease.
Mol Metab
; 50: 101143, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33346069
19.
Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD.
J Clin Invest
; 131(22)2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34499619
20.
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Nat Med
; 27(10): 1836-1848, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635855