Detalhe da pesquisa
1.
Biomacromolecule-Assisted Screening for Reaction Discovery and Catalyst Optimization.
Chem Rev
; 122(16): 13800-13880, 2022 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35904776
2.
Information-Rich, Dual-Function 13C/2H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme "Partitioning Fingerprint" and Reveals Disparate Chemotypes for hSR Inhibition.
J Am Chem Soc
; 145(5): 3158-3174, 2023 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36696670
3.
Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis.
Proc Natl Acad Sci U S A
; 116(51): 25634-25640, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31801874
4.
Rapid Enantioselective and Diastereoconvergent Hybrid Organic/Biocatalytic Entry into the Oseltamivir Core.
J Org Chem
; 86(9): 6494-6503, 2021 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33857378
5.
Crystal Structures of Cystathionine ß-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry
; 57(22): 3134-3145, 2018 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29630349
6.
Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for ß-elimination function.
J Biol Chem
; 292(34): 13986-14002, 2017 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28696262
7.
Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.
J Am Chem Soc
; 139(40): 14077-14089, 2017 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28906111
8.
Combining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biology.
J Am Chem Soc
; 137(10): 3600-9, 2015 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25719907
9.
Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.
Adv Synth Catal
; 357(8): 1619-1632, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26622223
10.
A useful methoxyvinyl cation equivalent: α-t-butyldimethylsilyl-α-methoxyacetaldehyde.
Tetrahedron Lett
; 56(23): 3575-3579, 2015 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26028786
11.
Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.
Sci Adv
; 10(13): eadk7201, 2024 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38536910
12.
Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes.
Proc Natl Acad Sci U S A
; 107(10): 4555-60, 2010 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20164409
13.
A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures.
Radiat Res
; 199(1): 89-111, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36368026
14.
Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography.
bioRxiv
; 2023 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37645800
15.
Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome.
Sci Rep
; 11(1): 5585, 2021 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33692493
16.
Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (S)-profens.
J Am Chem Soc
; 132(17): 5930-1, 2010 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20377222
17.
Rapid Entry into Biologically Relevant α,α-Difluoroalkylphosphonates Bearing Allyl Protection-Deblocking under Ru(II)/(IV)-Catalysis.
Org Lett
; 21(24): 9846-9851, 2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31789041
18.
Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.
Front Mol Biosci
; 6: 8, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30918891
19.
A set of phosphatase-inert "molecular rulers" to probe for bivalent mannose 6-phosphate ligand-receptor interactions.
Bioorg Med Chem Lett
; 18(10): 3085-9, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18068981
20.
Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical Advantages.
J Fluor Chem
; 129(9): 731-742, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19727327