Detalhe da pesquisa
1.
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Nature
; 609(7926): 416-423, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35830882
2.
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.
J Med Chem
; 65(24): 16173-16203, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36399068
3.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discov
; 12(6): 1500-1517, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404998
4.
A comparative study of fragment screening methods on the p38α kinase: new methods, new insights.
J Comput Aided Mol Des
; 25(7): 677-87, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21732248
5.
FARP2, HDLBP and PASK are downregulated in a patient with autism and 2q37.3 deletion syndrome.
Am J Med Genet A
; 149A(5): 952-9, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19365831
6.
New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse.
ACS Med Chem Lett
; 10(12): 1655-1660, 2019 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31857842
7.
Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
ACS Med Chem Lett
; 8(3): 338-343, 2017 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28337327
8.
Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.
ACS Med Chem Lett
; 7(8): 730-4, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27563394
9.
Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach.
ACS Med Chem Lett
; 7(8): 735-40, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27563395
10.
Mutation screening and association analysis of six candidate genes for autism on chromosome 7q.
Eur J Hum Genet
; 13(2): 198-207, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15523497
11.
Association studies of the HOPA dodecamer duplication variant in different subtypes of autism.
Am J Med Genet
; 114(1): 110-5, 2002 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11840515
12.
Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation.
J Biol Chem
; 282(44): 32152-7, 2007 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17848560
13.
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
Biochem Biophys Res Commun
; 348(3): 826-31, 2006 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16899217
14.
A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome.
Am J Hum Genet
; 70(4): 1034-7, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11885030
15.
Mutation analysis of the coding sequence of the MECP2 gene in infantile autism.
Hum Genet
; 111(4-5): 305-9, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12384770