Detalhe da pesquisa
1.
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice.
PLoS Pathog
; 18(5): e1010498, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35587469
2.
Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis.
Int J Mol Sci
; 24(24)2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38139224
3.
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis.
Angew Chem Int Ed Engl
; 61(39): e202203560, 2022 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35904863
4.
Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.
EMBO Mol Med
; 16(1): 93-111, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38177534
5.
A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards.
Pharmaceuticals (Basel)
; 16(5)2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37242554
6.
Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump.
Eur J Med Chem
; 259: 115630, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37459793
7.
Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification.
Pharmaceuticals (Basel)
; 16(3)2023 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36986435
8.
Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5.
J Med Chem
; 66(17): 11732-11760, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37639383
9.
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
J Med Chem
; 64(3): 1593-1610, 2021 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33470812
10.
Drug Target Engagement Using Coupled Cellular Thermal Shift Assay-Acoustic Reverse-Phase Protein Array.
SLAS Discov
; 25(2): 207-214, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31885312
11.
Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening.
Eur J Med Chem
; 200: 112440, 2020 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32505086
12.
Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox.
J Med Chem
; 60(21): 9067-9089, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28985084